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The map label for this gene is nuoF2 [H]

Identifier: 108760787

GI number: 108760787

Start: 1265717

End: 1267057

Strand: Reverse

Name: nuoF2 [H]

Synonym: MXAN_1085

Alternate gene names: 108760787

Gene position: 1267057-1265717 (Counterclockwise)

Preceding gene: 108760187

Following gene: 108761433

Centisome position: 13.86

GC content: 67.79

Gene sequence:

>1341_bases
ATGGCCTCTACGGCAAAGACGATCGAACCGATCATCTCGGCGGCCTGGGGTAAGCCTCAGTCCTGGACCCTGGACAGCTA
CCGCAAGCGGGGGGGCTACGAGGCGCTGAAGAAGGCGCTCCAGATGGAGCCCGCCGCCATCATCGACGAGGTGAAGAAGT
CGAACCTCCGCGGTCGCGGTGGCGCCGGCTTCCCCACGGGCCTCAAGTGGAGCTTCGTCCCCAAGGACAGCCCCAAGCCC
AAGTACCTGGCGGTCAACGGCGACGAGTCCGAGCCGGGCACCTTCAAGGACCGCTACATCCTCGAAGACGACCCGCACAT
GATGCTGGAGGGCATCGCCATCGCGTCCTACGCGCTGGGCGTGCACACCTGCTACGTGTACCTGCGCGGCGAGTTCAAGT
TCCCGGCGGAGCGCACGCAGGCGGCCATCGACGAGGCCTACAAGGCGGGCATCTTCGGCAAGAAGGTCCTGGGCAAGGAC
TACGAGCTGAACTGCTACCTGGTCCGCGGCGCGGGCGCCTACATCTGCGGCGAGGAGACGGCGCTGCTGGAGAGCCTGGA
AGGCAAGAAGGGCTGGCCCCGTCTTAAGCCGCCCTTCCCCGCGGTGGTGGGCCTCTTCGGCTGCCCCACGGTGGTGAACA
ACGTGGAGACGCTGGCCAGCGTGCCCGCCATCTTCCAGCAGGGCGCGGAGGCCTACGCGAAGCTGGGCACCGACAAGTCG
GGCGGCACGCGGCTCGTCTGCCTCTCCGGCACGGTGAACCGGCCGGGCGTGTACGAAGTGTCGATGTTCACGACCCTCTC
CGAGCTCATCTTCGACGACAAGTACGGCCGGGGCATGCCCGCGGGCCGGAAGGTGAAGGCCGTGATTCCGGGCGGCTCCT
CGGCGCCGGTGCTGGGCGCGGACGAGCTGGACGTGGCCATGGAGTTCGAGGCCCTCAAGGTGAAGCAGACCATGGCGGGC
TCCGGCGGCGTCATCGTCATGGACGACACCACCTGCATGGTGCGCAGCCTGTGGCGCGTGGCCCGCTTCTACGCGGAAGA
GTCGTGCGGTCAGTGCACGCCGTGCCGTGAAGGCACGCCCTGGCAGACGCGCCTCTTGCGCAAGATCGAAGAGGGCCGCG
GCGAGCCGGGCGACATCGACATGCTGTCCAACGTCGCGTCGTCGATCGCCCCCTACCCGCCCATCGGCCTGGGTAACACC
ATCTGCGCGCTCGGCGACGCGGCGGCGCTGCCCACGCACTCGTTCCTCATGCGGTTCCGGGACGAGTTCGAGGCTCACAT
CCGTGAGCACCGCTGCCCGTTCGGCGACAAGCCCTGGGGTTCGTTCGGAGACTGGTCTTGA

Upstream 100 bases:

>100_bases
ACGAGGATCACCACGAAAGCCTGACCCAGGCGAAGCTGGATGCCATCCTCGCCAAGTTGAGCTGAACCCCCACCCTTCTT
AGGCTTAGGACGTCATCGAC

Downstream 100 bases:

>100_bases
ACATCGAGCTCATCCTCTTCGGGGCGTTCGCGCTCCTGACGTTGCTGTCGGCTGGAACGGTCATCTTCGCGCGCAGCCCC
ATCAATTCGGCCATGGCGCT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRGGAGFPTGLKWSFVPKDSPKP
KYLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALGVHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKD
YELNCYLVRGAGAYICGEETALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKS
GGTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGADELDVAMEFEALKVKQTMAG
SGGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTPWQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNT
ICALGDAAALPTHSFLMRFRDEFEAHIREHRCPFGDKPWGSFGDWS

Sequences:

>Translated_446_residues
MASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRGGAGFPTGLKWSFVPKDSPKP
KYLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALGVHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKD
YELNCYLVRGAGAYICGEETALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKS
GGTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGADELDVAMEFEALKVKQTMAG
SGGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTPWQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNT
ICALGDAAALPTHSFLMRFRDEFEAHIREHRCPFGDKPWGSFGDWS
>Mature_445_residues
ASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRGGAGFPTGLKWSFVPKDSPKPK
YLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALGVHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKDY
ELNCYLVRGAGAYICGEETALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKSG
GTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGADELDVAMEFEALKVKQTMAGS
GGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTPWQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNTI
CALGDAAALPTHSFLMRFRDEFEAHIREHRCPFGDKPWGSFGDWS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=428, Percent_Identity=47.4299065420561, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI260656005, Length=428, Percent_Identity=47.4299065420561, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI1788620, Length=415, Percent_Identity=44.578313253012, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17531727, Length=427, Percent_Identity=45.9016393442623, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19920794, Length=423, Percent_Identity=46.5721040189125, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI45550452, Length=424, Percent_Identity=43.3962264150943, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24653819, Length=415, Percent_Identity=35.6626506024096, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24653817, Length=415, Percent_Identity=32.0481927710843, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48501; Mature: 48370

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRG
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GAGFPTGLKWSFVPKDSPKPKYLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALG
CCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
VHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKDYELNCYLVRGAGAYICGEET
HEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEEECCCEEEECCHH
ALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKS
HHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGA
CCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCC
DELDVAMEFEALKVKQTMAGSGGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTP
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
WQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNTICALGDAAALPTHSFLMRFR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHH
DEFEAHIREHRCPFGDKPWGSFGDWS
HHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRG
CCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GAGFPTGLKWSFVPKDSPKPKYLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALG
CCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
VHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKDYELNCYLVRGAGAYICGEET
HEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEEECCCEEEECCHH
ALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKS
HHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGA
CCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCC
DELDVAMEFEALKVKQTMAGSGGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTP
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
WQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNTICALGDAAALPTHSFLMRFR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHH
DEFEAHIREHRCPFGDKPWGSFGDWS
HHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]