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The map label for this gene is apr [H]

Identifier: 108760747

GI number: 108760747

Start: 251454

End: 252881

Strand: Direct

Name: apr [H]

Synonym: MXAN_0206

Alternate gene names: 108760747

Gene position: 251454-252881 (Clockwise)

Preceding gene: 108759343

Following gene: 108761769

Centisome position: 2.75

GC content: 68.0

Gene sequence:

>1428_bases
ATGAAGTCCTACCTGTTGGTTCCAAAGGAGTCCATCGAGACGCAGGCTCGTGTGGGGCCTCGCGGCACGGAGCAGGGCGA
GCGCGTGCTGTCGCGCACGACGGCGCTGCGCTTCGCGGTGGCGAACAAGGCGCCCGACGCGTTGTTCGCTCTCGGACTGC
GGTCGGCCACGCTGCCCGGCGCGCGTCCGCCCGTCAGTGGACAGGAAGAGCGCCGTCGGAAGGGCAAGGGCGCGAAGTCG
GCGCGCACGGGCACGCGCGGCGCGGACTCCTCCACGCCGCCCATGCCGGGCGCGACGGTGGCCGAGCAGACCGGCGCGGA
GCCCGGCAGCTACCGGTACATGCCGCTCATCGGTGCCACCATGGCTCACTTCTACGAAGACCATACGGAGAAGGAAGCCC
GCGGCGAGCTGGAACGCGACTTCGAGTTCATCCCCGACGTCGTCCCGTTGTCCTTCCCCGGCCCGGTGTCGGCTGGACAA
CCCGGACCGCGCAACCGGGGCATGTCCTCGCTGGCCGAGCGCGAGTGGCCCGACGAGTGCGGCGTTCCCCTGGCCCACGC
CCAGGGCATCCGCGGCGCCGGCGTCATGCTGGGCATCCTCGACACCGGTGTGGACGCGGACCACCCCGAGCACGCGGCGC
GCGTCATCCAGTTCCGCTACGTGTCGCTGTTCCCCAACTCGCCGCACAATCCGGCGCGTGACATCCGCGGCTTCGACCCG
GACGGCCACGGTACGCACGTGTGCGGCATTGCCGCGGGTGTGCACCACGGCGTCGCCCCGGAGGTGGACCTCTACGTCGC
GTCCGTTATCGAATCGGAGACCATCCGCACCAGCCTGGGCCGCGTGGCCGCGGGCATGGAGTGGCTGCTGCACCAGTTCA
GCCGCCCGGAGAACTCGACGCGGCCCGCGGTGGTCAACCTGTCGCTCGGCTTCCCGCTGATGCCGCCGCCCGGCATCTCG
GAGGCGGACTACAACCTCAACCTGCGCGCGCTGCAGACGATGATTCGTCGCCTGCTCGACAGCAATGTCCTGCCGGTTGT
GGCGGCAGGTAACAGTGGACCCGACACGGTTGGTTATCCAGCCGCCTTTCCAGAGTCACTGGCTGTCGGCGCGGTCGACT
TCGAGCGTAACGTGGCCACATTCTCCGCGAGTGGCACCGTGGGTAGGCGCGTCGTGCCGGACATCATGGGGTATGGGGTG
AATGTCTATTCCAGCACGGAGCGTCGTTGTAACAACCAGGCGTTCTACGAGCGAATGAGTGGCACGAGCATGGCAGCGCC
TTATGTAGCGGGTATCGCGGCGCTGTACCGTTGCCGTGCCCCTGACTTGACGGCGCTCGAGGTGAGGGATTTGATCCTGT
CGAATGCGGTGAAGCTCCCTCGGTCGGGAACGCACAAGACAGGCAAGGGCCTGGCCGTATTCAGGTGA

Upstream 100 bases:

>100_bases
GCACGCGCGAGGCTCCGCACGCGACGGGTGCTGACCTGATGCCGGATGACCTCGCCTCATGCGTCCGGCGTAGCACGGTG
GTTCAAGGAGCACACAACCC

Downstream 100 bases:

>100_bases
CGGTGGCGGTTGAATCCGGGGTCGGCGCCATGGGAGCGCCGGACCCGGGAGAGGATGAGGGCCATGAGCAGGAAAAATGG
CGAGTGGGGGGACGTCCGGG

Product: S8A family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPGARPPVSGQEERRRKGKGAKS
ARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGATMAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQ
PGPRNRGMSSLAEREWPDECGVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDP
DGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENSTRPAVVNLSLGFPLMPPPGIS
EADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYPAAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGV
NVYSSTERRCNNQAFYERMSGTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR

Sequences:

>Translated_475_residues
MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPGARPPVSGQEERRRKGKGAKS
ARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGATMAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQ
PGPRNRGMSSLAEREWPDECGVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDP
DGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENSTRPAVVNLSLGFPLMPPPGIS
EADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYPAAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGV
NVYSSTERRCNNQAFYERMSGTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR
>Mature_475_residues
MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPGARPPVSGQEERRRKGKGAKS
ARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGATMAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQ
PGPRNRGMSSLAEREWPDECGVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDP
DGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENSTRPAVVNLSLGFPLMPPPGIS
EADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYPAAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGV
NVYSSTERRCNNQAFYERMSGTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=304, Percent_Identity=27.9605263157895, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324576, Length=281, Percent_Identity=28.4697508896797, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319893, Length=281, Percent_Identity=28.4697508896797, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320775, Length=255, Percent_Identity=27.843137254902, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550681, Length=324, Percent_Identity=28.0864197530864, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 50841; Mature: 50841

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPG
CCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
ARPPVSGQEERRRKGKGAKSARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGAT
CCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEHHHHHHH
MAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQPGPRNRGMSSLAEREWPDEC
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHH
GVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDP
CCCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEECCCCCCCHHHHCCCCCC
DGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENST
CCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RPAVVNLSLGFPLMPPPGISEADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYP
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
AAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGVNVYSSTERRCNNQAFYERMS
CCCCHHHEEEEEECCCCCEEEECCCCCCCHHHHHHHHCCCEEECCHHHHHCHHHHHHHHC
GTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPG
CCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
ARPPVSGQEERRRKGKGAKSARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGAT
CCCCCCCHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEHHHHHHH
MAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQPGPRNRGMSSLAEREWPDEC
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHH
GVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDP
CCCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEECCCCCCCHHHHCCCCCC
DGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENST
CCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RPAVVNLSLGFPLMPPPGISEADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYP
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
AAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGVNVYSSTERRCNNQAFYERMS
CCCCHHHEEEEEECCCCCEEEECCCCCCCHHHHHHHHCCCEEECCHHHHHCHHHHHHHHC
GTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]