Click here to switch to the map view.

The map label for this gene is creC [H]

Identifier: 108760705

GI number: 108760705

Start: 5114746

End: 5116326

Strand: Direct

Name: creC [H]

Synonym: MXAN_4165

Alternate gene names: 108760705

Gene position: 5114746-5116326 (Clockwise)

Preceding gene: 108763454

Following gene: 108756865

Centisome position: 55.96

GC content: 72.23

Gene sequence:

>1581_bases
GTGTTCGCCGCCGTGGGCGTGGCGGGGTTCGCCCTCACGCTGGCGGGGCTCGCCTTCGTGCGCGTCTACGACAACCAGCT
CATCCGCCAGACGGAGTCGGAGCTGATTGCCCAGGGCGCGGTGGTCGCGGAGGTCTTCCGCGAGCGGCTGCGCGCCACCG
TGCCAGAGGGCGCCTACGGCCGCGAGCGCACCGCTCCCTGGCCCTTCCCCATTCCCGACGACACGCGCCTGCGCCCCATC
CTCCCGTCGCTCAGGGCCTCGGATGCATCCCTGCCGCCGGGCGACACGCCTCGGCCTTCACGTGTTCCCGCGGAGCCGCT
GTCACACGCGGCTGGACTGCAACTGACGCCGCTGCTCGAACAGGTGCGTGCGGCGACGCTGGCCGGCATCCGCGTGGTAG
ACACCGAGGGCGTGGTCGTGGCCAGCAGCAGCTCCGCCCTGCTGTGGACGACGCTGGCGGACCGCACAGAGGTCCAGCGG
GCCCTGCGCGGCGAGCCCGTCAGCGTGCTGCGCCGCCGCGTCGCCGATCCCGAGGACACCCCGCTGGCGTCGCTCAGCCG
CGACACCGGCATCCGCGTCACGGTGGCGTTGCCCGTGCTGGAAGGCGATCGCGTCTGGGGCGCGGTGGTGCTGACGCGCA
CGCCCATGACGTTCGCCAAGGCGACGTACGCGGACCGGTGGAACCTCACCGCCACTGGCTTCGTGTTGCTCGGCGCGGTG
GCGCTGATGTCCCTGGCCGCCGCGGCGCTGGTGGGCCGGCCGGTGCGCGCGCTGGTGAAGCAGACGCGCGCCATCGCCAT
GAGCGACCCTTCGGGCTTCGAGCCCATGGCGCGCCCCGTGGTGGCCGAGCTGGCCGAGCTCTCCGAATCCCTGGCCGGCA
TGGCCACCGCGTTGCGAGACAGGAACCAGTACATCCGTTCCTTCGCGGCCAACGTGTCGCACGAGTTCAAGACGCCGCTG
GCCTCCATCCAAGGCGCGGTGGAGCTGCTGCGCGACAGCGCCGACGCGATGTCCCCCGAGCAACGCGCGCGATTCCTCGC
CAACGTGGACGCGGATGCCCGCAGGCTCACCCGACTGGTGCAGCGCCTGCTGGAGCTGGCCCGGGCGGACTCCATGACGG
CCACGCCCGCGCAGGTGGAGCTGGGCCCGCTGTTGGAGGGGCTCGCCCTCCGCGCCCGCGCCGACGGTGCCACGGCCATC
CATGTGACGGCACCACCCGCGGGCCTGAAGGTGAGCCTCCCGCAGGAAGTGCTCGACGATGTGCTGTGGCAGCTCGTCAC
CAATGCCCGCCAGCACGGTGGCGACACCGTCCGCGTGGACCTGTCGGTGGAGCAGGCCCCGGAGGCGGACCTGGTGCGCG
TGGTGGTGAAGGACCGCGGCAAGGGCATCTCCGAGTCCAACCGTGCGCGCATCTTCGACGCCTTCTTCACCACTGCCCGC
GAGCGCGGCGGCACGGGCCTGGGGCTGACGATTGCCCAGTCCATGCTGCGCGCCTTCCACGCGAGGTTGGAGCTGCTTCC
TTCCGACACGGGCACCACCTTCGCGGTGGTGGCGCCCGTGCCCCGGCTTCAACGGAAGTAG

Upstream 100 bases:

>100_bases
AAGTTCGCGAGCGCGGGCGGAGACGTCATCGAGACGGTGCATGGCCTTGGCTATCGGCTCGCCCTCCCCTGAGCGCCGCG
CGCGCCCGCGCTTGTGGCTG

Downstream 100 bases:

>100_bases
CTGTCGGAGATGTCCACGGAGTAGCCCAGCTCCAGCGTGGGCGAGGACGCGGCCACCAGGAACTGGCGGAAGTGCAGCGC
CTTCCCGGGCAGGCCCGACG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MFAAVGVAGFALTLAGLAFVRVYDNQLIRQTESELIAQGAVVAEVFRERLRATVPEGAYGRERTAPWPFPIPDDTRLRPI
LPSLRASDASLPPGDTPRPSRVPAEPLSHAAGLQLTPLLEQVRAATLAGIRVVDTEGVVVASSSSALLWTTLADRTEVQR
ALRGEPVSVLRRRVADPEDTPLASLSRDTGIRVTVALPVLEGDRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAV
ALMSLAAAALVGRPVRALVKQTRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRDRNQYIRSFAANVSHEFKTPL
ASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLVQRLLELARADSMTATPAQVELGPLLEGLALRARADGATAI
HVTAPPAGLKVSLPQEVLDDVLWQLVTNARQHGGDTVRVDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTAR
ERGGTGLGLTIAQSMLRAFHARLELLPSDTGTTFAVVAPVPRLQRK

Sequences:

>Translated_526_residues
MFAAVGVAGFALTLAGLAFVRVYDNQLIRQTESELIAQGAVVAEVFRERLRATVPEGAYGRERTAPWPFPIPDDTRLRPI
LPSLRASDASLPPGDTPRPSRVPAEPLSHAAGLQLTPLLEQVRAATLAGIRVVDTEGVVVASSSSALLWTTLADRTEVQR
ALRGEPVSVLRRRVADPEDTPLASLSRDTGIRVTVALPVLEGDRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAV
ALMSLAAAALVGRPVRALVKQTRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRDRNQYIRSFAANVSHEFKTPL
ASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLVQRLLELARADSMTATPAQVELGPLLEGLALRARADGATAI
HVTAPPAGLKVSLPQEVLDDVLWQLVTNARQHGGDTVRVDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTAR
ERGGTGLGLTIAQSMLRAFHARLELLPSDTGTTFAVVAPVPRLQRK
>Mature_526_residues
MFAAVGVAGFALTLAGLAFVRVYDNQLIRQTESELIAQGAVVAEVFRERLRATVPEGAYGRERTAPWPFPIPDDTRLRPI
LPSLRASDASLPPGDTPRPSRVPAEPLSHAAGLQLTPLLEQVRAATLAGIRVVDTEGVVVASSSSALLWTTLADRTEVQR
ALRGEPVSVLRRRVADPEDTPLASLSRDTGIRVTVALPVLEGDRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAV
ALMSLAAAALVGRPVRALVKQTRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRDRNQYIRSFAANVSHEFKTPL
ASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLVQRLLELARADSMTATPAQVELGPLLEGLALRARADGATAI
HVTAPPAGLKVSLPQEVLDDVLWQLVTNARQHGGDTVRVDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTAR
ERGGTGLGLTIAQSMLRAFHARLELLPSDTGTTFAVVAPVPRLQRK

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=393, Percent_Identity=25.4452926208651, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788393, Length=293, Percent_Identity=29.6928327645051, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=268, Percent_Identity=29.8507462686567, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=28.6995515695067, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=26.9565217391304, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=25.9414225941423, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=287, Percent_Identity=25.7839721254355, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=30.2752293577982, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789403, Length=301, Percent_Identity=26.2458471760797, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56463; Mature: 56463

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAAVGVAGFALTLAGLAFVRVYDNQLIRQTESELIAQGAVVAEVFRERLRATVPEGAYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RERTAPWPFPIPDDTRLRPILPSLRASDASLPPGDTPRPSRVPAEPLSHAAGLQLTPLLE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHH
QVRAATLAGIRVVDTEGVVVASSSSALLWTTLADRTEVQRALRGEPVSVLRRRVADPEDT
HHHHHHHHCEEEEECCCEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PLASLSRDTGIRVTVALPVLEGDRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAV
CHHHHCCCCCCEEEEEEEEECCCCEEEEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHH
ALMSLAAAALVGRPVRALVKQTRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRD
HHHHHHHHHHHCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RNQYIRSFAANVSHEFKTPLASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLV
HHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
QRLLELARADSMTATPAQVELGPLLEGLALRARADGATAIHVTAPPAGLKVSLPQEVLDD
HHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECCHHHHHH
VLWQLVTNARQHGGDTVRVDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTAR
HHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ERGGTGLGLTIAQSMLRAFHARLELLPSDTGTTFAVVAPVPRLQRK
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHCCC
>Mature Secondary Structure
MFAAVGVAGFALTLAGLAFVRVYDNQLIRQTESELIAQGAVVAEVFRERLRATVPEGAYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RERTAPWPFPIPDDTRLRPILPSLRASDASLPPGDTPRPSRVPAEPLSHAAGLQLTPLLE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHH
QVRAATLAGIRVVDTEGVVVASSSSALLWTTLADRTEVQRALRGEPVSVLRRRVADPEDT
HHHHHHHHCEEEEECCCEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PLASLSRDTGIRVTVALPVLEGDRVWGAVVLTRTPMTFAKATYADRWNLTATGFVLLGAV
CHHHHCCCCCCEEEEEEEEECCCCEEEEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHH
ALMSLAAAALVGRPVRALVKQTRAIAMSDPSGFEPMARPVVAELAELSESLAGMATALRD
HHHHHHHHHHHCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RNQYIRSFAANVSHEFKTPLASIQGAVELLRDSADAMSPEQRARFLANVDADARRLTRLV
HHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
QRLLELARADSMTATPAQVELGPLLEGLALRARADGATAIHVTAPPAGLKVSLPQEVLDD
HHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECCHHHHHH
VLWQLVTNARQHGGDTVRVDLSVEQAPEADLVRVVVKDRGKGISESNRARIFDAFFTTAR
HHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
ERGGTGLGLTIAQSMLRAFHARLELLPSDTGTTFAVVAPVPRLQRK
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]