Click here to switch to the map view.

The map label for this gene is add [H]

Identifier: 108760581

GI number: 108760581

Start: 1781811

End: 1782878

Strand: Direct

Name: add [H]

Synonym: MXAN_1519

Alternate gene names: 108760581

Gene position: 1781811-1782878 (Clockwise)

Preceding gene: 108756852

Following gene: 108761429

Centisome position: 19.5

GC content: 67.32

Gene sequence:

>1068_bases
GTGACGGAAGAGCTGTTGCGCGCACTGCCCAAGACGGACCTCCACTGCCACCTGGACGGGTCCATGCGCCTGAAGACCAT
CCTGGAGCTGGCCGAGCAGCAGAAAATCAAGCTGCTCGCCGACACCGAGGATGGGCTGGCCAAGGCCATCCACATGGGCG
AGGTGTGCGAGAGCCTGGAGGAGTACCTCGTCGCCTTCGACGTGACGCTCTCCGTGCTCCAGACGGCCGAGTCCCTCTAC
CGCGCCGCCTACGAGCTGGCCGTGGACGCCGCCGCGGAGAACGTGCGCTGGCTGGAGGTTCGCTATTCGCCCGCGCTGCA
CCTGCAGAAGGGCCTGAAGATGACTACGGTCATCGACTCCGTGCTGGAGGGCCTGCGCGCCGCGAAGCGGGAGACGGGCA
TCAAGTGCGGCGTCATCGTCTGCGGCATCCGCCACATCAACCCGCAGACGTCCATGCGGCTGGCGGAGCTGGCGGTGGCC
TACAAGAACCGCGGCGTCATCGGCTTCGACCTGGCCGGCGCGGAGGCGAGCTTCCCGGCGAAGGACCACCGGGACGCCTT
CCAGCTCATCCTCAAGAACAACGTCAACTGCACCGCGCACGCGGGCGAGGCCTACGGCCCCGAGTCCATCTCCCAGGCCA
TCCACAACCTGGGCGCGCACCGCATCGGCCACGGCACGCGGCTGCGCGAGGACGGGGACCTGCTCAACTACGTCAACGAC
CACCGCATCCCGCTGGAGGTGTGCCCCACCTCCAACGTGCAGACGGGCGCCGTGACGAGCCTGGCGGCGCACCCGCTGAA
GTTCTACTTCGACTACGGCCTGCGGGTGACCATCAACACGGACAACCGCCTCATCACCGACACCACGGTAACCAAGGAGC
TGTGGACGGCGCACTCCGCGCTGGGCCTGTCGCTGGAGGACCTGACCACCATCCTCGTCTCCGGCTTCAAGAGCGCCTTC
CTCCCGTTCCGGGAGAAGCAGGACATGCTGCGGGCGGTGAACGAGGAGATCGCCCAGACGCTGGCGGCCTTCGACCAGAA
GCGGCACCTGGTGAAGCAGCCCGCTTGA

Upstream 100 bases:

>100_bases
TTGGACCATGCCTACCATTCGTGATGACGAGATTCCCAGCGCCACCGGCATTCCTTCGTCCGCCCGTCGGACGGACTTCG
TGCCGCCGCCCACCCTGGCG

Downstream 100 bases:

>100_bases
TGACGTGACGTCCGGCGTCCCGGCCCCGTGCAAGGTGCAGTCGCCTCGCGGGGCCGGCGCTGGCCGCGAGGAGGTGGCGC
GTGGACCTGGAACTGGGTGG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase 2 [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLEEYLVAFDVTLSVLQTAESLY
RAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDSVLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVA
YKNRGVIGFDLAGAEASFPAKDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVND
HRIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSALGLSLEDLTTILVSGFKSAF
LPFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA

Sequences:

>Translated_355_residues
MTEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLEEYLVAFDVTLSVLQTAESLY
RAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDSVLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVA
YKNRGVIGFDLAGAEASFPAKDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVND
HRIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSALGLSLEDLTTILVSGFKSAF
LPFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA
>Mature_354_residues
TEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLEEYLVAFDVTLSVLQTAESLYR
AAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDSVLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVAY
KNRGVIGFDLAGAEASFPAKDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVNDH
RIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSALGLSLEDLTTILVSGFKSAFL
PFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=338, Percent_Identity=31.6568047337278, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI61175224, Length=245, Percent_Identity=28.1632653061224, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1787910, Length=331, Percent_Identity=35.6495468277946, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32565969, Length=336, Percent_Identity=31.8452380952381, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17538512, Length=336, Percent_Identity=31.8452380952381, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI115537133, Length=334, Percent_Identity=27.8443113772455, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324188, Length=288, Percent_Identity=27.4305555555556, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24645260, Length=340, Percent_Identity=28.5294117647059, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 39221; Mature: 39090

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLE
CCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
EYLVAFDVTLSVLQTAESLYRAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCHHHHHHHH
VLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVAYKNRGVIGFDLAGAEASFPA
HHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
KDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVND
CHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHCC
HRIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSA
CCCEEEECCCCCCCCCHHHHHHHHHHHEEEECCEEEEEECCCEEEECHHHHHHHHHHHHH
LGLSLEDLTTILVSGFKSAFLPFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA
HCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLE
CHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
EYLVAFDVTLSVLQTAESLYRAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCHHHHHHHH
VLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVAYKNRGVIGFDLAGAEASFPA
HHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
KDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVND
CHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHCC
HRIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSA
CCCEEEECCCCCCCCCHHHHHHHHHHHEEEECCEEEEEECCCEEEECHHHHHHHHHHHHH
LGLSLEDLTTILVSGFKSAFLPFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA
HCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]