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The map label for this gene is ysnA [H]

Identifier: 108760288

GI number: 108760288

Start: 2337468

End: 2338061

Strand: Direct

Name: ysnA [H]

Synonym: MXAN_2005

Alternate gene names: 108760288

Gene position: 2337468-2338061 (Clockwise)

Preceding gene: 108758625

Following gene: 108763895

Centisome position: 25.57

GC content: 71.72

Gene sequence:

>594_bases
ATGACGGTGAAGCCCCGGCTGCTGTTCGCGACGACCAACCAGGGCAAGCTGCGCGAGCTGCGTGGCCTCGTCGGAGACGC
GGTGGAGGTGGTGTCCCTGGCGGACCTGCCGCCTGTCCCCGAGCCCGTGGAGGACGGCGCCACGTTCGAGGAGAACGCGG
TGATGAAGGCCCGCGCCTACGCGGACGCCACCGGGCTGCTCACCCTGGCGGATGACTCCGGCCTGTGCGTGGACGCGCTG
GGCGGACGGCCCGGCGTGCAGTCCGCGCGGTATGCCCCGGGGGACGACCGGGCCCGCTACGAGAAGCTGCTGACCGAGCT
GACCGGGGTGCCCGACGCCCAGCGCACCGCGTCCTTCCGCTGCGCGCTGGCGCTGGTGGGGCCCGGGGGAGGGGAGGCGA
AGGTGGAGGTGGGGCAGTGCAACGGCCGTATCGGCCACGCCCCGAAGGGAAGCCATGGTTTCGGCTATGACCCCGTCTTC
ATCCTTCCGGGCGGCGACCGTGCCCTGGCGGAGCTGACGCCGGAGGAGAAGTCGGCCATTTCCCACCGGGGGAAGGCCTT
CCAGAAGATGAAGCCCCACCTGCTGGGCTTGTAG

Upstream 100 bases:

>100_bases
CGGAGCACCAGCTCTTCGACCGCAAGGCCCTGGACGCCATGGTGGATGGCGGGCTGGCCGCCATCCAGAAGCTGACGGCC
GCGCAGGCGCAGGTGCTGGG

Downstream 100 bases:

>100_bases
CCGTCCGGAATGCGAGGCCGTCAGTCACGTCGGCCTTGCGCGTCCGTTCGGGATGGTTCAACAATGCCGGACTTCTCGGG
GCGTAGCGCAGCCTGGTAGC

Product: RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAYADATGLLTLADDSGLCVDAL
GGRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFRCALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVF
ILPGGDRALAELTPEEKSAISHRGKAFQKMKPHLLGL

Sequences:

>Translated_197_residues
MTVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAYADATGLLTLADDSGLCVDAL
GGRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFRCALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVF
ILPGGDRALAELTPEEKSAISHRGKAFQKMKPHLLGL
>Mature_196_residues
TVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAYADATGLLTLADDSGLCVDALG
GRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFRCALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVFI
LPGGDRALAELTPEEKSAISHRGKAFQKMKPHLLGL

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=193, Percent_Identity=29.0155440414508, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789324, Length=189, Percent_Identity=45.5026455026455, Blast_Score=143, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17556833, Length=193, Percent_Identity=30.0518134715026, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920712, Length=188, Percent_Identity=29.2553191489362, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 20702; Mature: 20571

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAY
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
ADATGLLTLADDSGLCVDALGGRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFR
CCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEE
CALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVFILPGGDRALAELTPEEKSAI
EEEEEECCCCCCEEEEEECCCCEECCCCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHH
SHRGKAFQKMKPHLLGL
HHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAY
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
ADATGLLTLADDSGLCVDALGGRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFR
CCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEE
CALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVFILPGGDRALAELTPEEKSAI
EEEEEECCCCCCEEEEEECCCCEECCCCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHH
SHRGKAFQKMKPHLLGL
HHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1624460 [H]