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The map label for this gene is ada [H]

Identifier: 108760264

GI number: 108760264

Start: 3045592

End: 3047184

Strand: Reverse

Name: ada [H]

Synonym: MXAN_2612

Alternate gene names: 108760264

Gene position: 3047184-3045592 (Counterclockwise)

Preceding gene: 108762450

Following gene: 108758006

Centisome position: 33.34

GC content: 72.57

Gene sequence:

>1593_bases
ATGAACGGCTTGGACGCCAGCGCGTGCTACCGCGCGATGCAGACCCGAGATGCCCGCTTCGACGGCCGGTTCTTCACCGC
CGTCCGGACGACGCGCATCTATTGCCGGCCCATCTGCCCGGCCCGGACGCCCCGGTTCGAGAACTGCACCTTCTATCCGA
GCGCCGCCGGGGCGCAGGAGGCGGGCTACCGGCCCTGCCTGCGCTGCCGCCCGGAGACGTCACCGGACCTCGCCTTCTGG
CGGGGCACCTCCAACACCGTCGCCCGGGCCCTGGCGCTCATCGCCGAGGGCGGCCTGGATGACGACGATGCCGGGGTGGA
GGAGCTCGCGGGCCGGCTGGGCGTGGGCGACCGGCAGCTGCGGCGGTTGTTCCAGCAGCACCTGGGAGCCTCGCCCGTAG
CCGTCGCCCAGACACGGCGTGTGCTGTTCGCCCGGCAGCTCCTGCACGAGACGACCCTGCCCATGGCCGAGGTGGCACTG
GCCTCGGGGTTCCGCAGCGTCCGCCGCTTCAACGACGTGTTCCGCGCCCTGTATGGACGGCCTCCCAGCGCGCTCCGCCG
GAGCCGAGCCCCGGTGGGCGATGCCGCCGCGGGTGTCACGCTCTTCATCCCCTACCAGCCCCCCTATGACTGGGAAGCGA
TGCTGGCGCATCTGGAGGCACGGGCCCTACCGGGCCTGGAACACATCGAGGCCGGGCGCTACCGGCGGACCGTGGCGACC
GCGGGCGGTCAGGGCGCCGTCGAAGTCTTCCGAGCCCCTGGACGCGACGGGTTGCTCGCGACGCTCCGCCTCCCCCAGGT
TCAGGCCCTGCCCACGGTGGTGGGGCAGGTCCGGCGCGTCTTCGACGTGGGCGCGGACATGGACGTCATCCGGGAACACC
TGTCCCGCGACCCGCACCTCGCTCCGCTGGTGTCCCTGCGGCCGGGACTGCGAGCGCCGGGAGGCTGGGACGGCTTCGAG
CTCGCGGTCCGGGCCGTGTTGGGACAGCAAGTCACGGTCGCCGCGGCGCGCGGACTCGGGGCGCGGCTGGTCGCGGCGTA
TGGCGAGCCCGCCGGTGTCGCATCGACGGGAGACGCCCGGCTGATGCGCACCTTTCCCCGGCCGGAGAGACTGGCGCAGG
AGGACTTGAGCTCGCTCGGCATGCCCGCCGCCAGGGCACGGACCCTGTCGAGCCTGGCCGCGGCGGCCGCAGCGGACCCG
AGGCTGTTCCAGCCACGCGCCACGCTGGAGGAGGCCGTCGAACGCTTCAAACGCATCCCCGGCATCGGAGATTGGACGGC
GCAGTACATCGCGCTGCGCGCCGTGCGCGAAACGGATGCCTTCCCTTCGGCGGATGTCGCACTGCTGCGTGCGCTCACGG
GCGAGGATGGCGTGCGGCCTTCTCCAGATGAAGCGCTCCGCCGCTCCGCGGCCTGGAGCCCCTGGCGTGCCTATGCAGCA
CAGCACCTCTGGGCCGCGGATGCCGCCCGGCCCGGACCCACACCCCACCTTTCCCGTTCCTCCTCGCGACAGAGAGATGA
CGATGCCCCCACCGCTGCGTTTGCTCATGGACCGCGCCCCCACGCCCATCGGCTCGATGCTGGTCGTCTGTGA

Upstream 100 bases:

>100_bases
CGAACCCTGGGCCCAGCGGATGACGCACCCCGTCCAACCCGTGCCATTGAAGTCCGAAAGCGGCCAGACAGCGGCCACCC
GGTATGGGAGTTTGCCCTCC

Downstream 100 bases:

>100_bases
CGAAGCGGGCAGCCTGCGCGCGCTCGACTGGGAGGAGTACGAGCCCCGGATGCTCCGGCTGCTGCGGCTCCACTACGGCG
TGAACGGCTACGTGCTCGAG

Product: putative ada regulatory protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MNGLDASACYRAMQTRDARFDGRFFTAVRTTRIYCRPICPARTPRFENCTFYPSAAGAQEAGYRPCLRCRPETSPDLAFW
RGTSNTVARALALIAEGGLDDDDAGVEELAGRLGVGDRQLRRLFQQHLGASPVAVAQTRRVLFARQLLHETTLPMAEVAL
ASGFRSVRRFNDVFRALYGRPPSALRRSRAPVGDAAAGVTLFIPYQPPYDWEAMLAHLEARALPGLEHIEAGRYRRTVAT
AGGQGAVEVFRAPGRDGLLATLRLPQVQALPTVVGQVRRVFDVGADMDVIREHLSRDPHLAPLVSLRPGLRAPGGWDGFE
LAVRAVLGQQVTVAAARGLGARLVAAYGEPAGVASTGDARLMRTFPRPERLAQEDLSSLGMPAARARTLSSLAAAAAADP
RLFQPRATLEEAVERFKRIPGIGDWTAQYIALRAVRETDAFPSADVALLRALTGEDGVRPSPDEALRRSAAWSPWRAYAA
QHLWAADAARPGPTPHLSRSSSRQRDDDAPTAAFAHGPRPHAHRLDAGRL

Sequences:

>Translated_530_residues
MNGLDASACYRAMQTRDARFDGRFFTAVRTTRIYCRPICPARTPRFENCTFYPSAAGAQEAGYRPCLRCRPETSPDLAFW
RGTSNTVARALALIAEGGLDDDDAGVEELAGRLGVGDRQLRRLFQQHLGASPVAVAQTRRVLFARQLLHETTLPMAEVAL
ASGFRSVRRFNDVFRALYGRPPSALRRSRAPVGDAAAGVTLFIPYQPPYDWEAMLAHLEARALPGLEHIEAGRYRRTVAT
AGGQGAVEVFRAPGRDGLLATLRLPQVQALPTVVGQVRRVFDVGADMDVIREHLSRDPHLAPLVSLRPGLRAPGGWDGFE
LAVRAVLGQQVTVAAARGLGARLVAAYGEPAGVASTGDARLMRTFPRPERLAQEDLSSLGMPAARARTLSSLAAAAAADP
RLFQPRATLEEAVERFKRIPGIGDWTAQYIALRAVRETDAFPSADVALLRALTGEDGVRPSPDEALRRSAAWSPWRAYAA
QHLWAADAARPGPTPHLSRSSSRQRDDDAPTAAFAHGPRPHAHRLDAGRL
>Mature_530_residues
MNGLDASACYRAMQTRDARFDGRFFTAVRTTRIYCRPICPARTPRFENCTFYPSAAGAQEAGYRPCLRCRPETSPDLAFW
RGTSNTVARALALIAEGGLDDDDAGVEELAGRLGVGDRQLRRLFQQHLGASPVAVAQTRRVLFARQLLHETTLPMAEVAL
ASGFRSVRRFNDVFRALYGRPPSALRRSRAPVGDAAAGVTLFIPYQPPYDWEAMLAHLEARALPGLEHIEAGRYRRTVAT
AGGQGAVEVFRAPGRDGLLATLRLPQVQALPTVVGQVRRVFDVGADMDVIREHLSRDPHLAPLVSLRPGLRAPGGWDGFE
LAVRAVLGQQVTVAAARGLGARLVAAYGEPAGVASTGDARLMRTFPRPERLAQEDLSSLGMPAARARTLSSLAAAAAADP
RLFQPRATLEEAVERFKRIPGIGDWTAQYIALRAVRETDAFPSADVALLRALTGEDGVRPSPDEALRRSAAWSPWRAYAA
QHLWAADAARPGPTPHLSRSSSRQRDDDAPTAAFAHGPRPHAHRLDAGRL

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=292, Percent_Identity=34.5890410958904, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788542, Length=131, Percent_Identity=35.1145038167939, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 57524; Mature: 57524

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLDASACYRAMQTRDARFDGRFFTAVRTTRIYCRPICPARTPRFENCTFYPSAAGAQE
CCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHEEEEEECCCCCCCCCCCCEECCCCCCCCC
AGYRPCLRCRPETSPDLAFWRGTSNTVARALALIAEGGLDDDDAGVEELAGRLGVGDRQL
CCCCCHHCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHH
RRLFQQHLGASPVAVAQTRRVLFARQLLHETTLPMAEVALASGFRSVRRFNDVFRALYGR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PPSALRRSRAPVGDAAAGVTLFIPYQPPYDWEAMLAHLEARALPGLEHIEAGRYRRTVAT
CHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHC
AGGQGAVEVFRAPGRDGLLATLRLPQVQALPTVVGQVRRVFDVGADMDVIREHLSRDPHL
CCCCCCHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
APLVSLRPGLRAPGGWDGFELAVRAVLGQQVTVAAARGLGARLVAAYGEPAGVASTGDAR
CHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHEECCCCCCCCCCCCHH
LMRTFPRPERLAQEDLSSLGMPAARARTLSSLAAAAAADPRLFQPRATLEEAVERFKRIP
HHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
GIGDWTAQYIALRAVRETDAFPSADVALLRALTGEDGVRPSPDEALRRSAAWSPWRAYAA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHH
QHLWAADAARPGPTPHLSRSSSRQRDDDAPTAAFAHGPRPHAHRLDAGRL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNGLDASACYRAMQTRDARFDGRFFTAVRTTRIYCRPICPARTPRFENCTFYPSAAGAQE
CCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHEEEEEECCCCCCCCCCCCEECCCCCCCCC
AGYRPCLRCRPETSPDLAFWRGTSNTVARALALIAEGGLDDDDAGVEELAGRLGVGDRQL
CCCCCHHCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHH
RRLFQQHLGASPVAVAQTRRVLFARQLLHETTLPMAEVALASGFRSVRRFNDVFRALYGR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PPSALRRSRAPVGDAAAGVTLFIPYQPPYDWEAMLAHLEARALPGLEHIEAGRYRRTVAT
CHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHC
AGGQGAVEVFRAPGRDGLLATLRLPQVQALPTVVGQVRRVFDVGADMDVIREHLSRDPHL
CCCCCCHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
APLVSLRPGLRAPGGWDGFELAVRAVLGQQVTVAAARGLGARLVAAYGEPAGVASTGDAR
CHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHEECCCCCCCCCCCCHH
LMRTFPRPERLAQEDLSSLGMPAARARTLSSLAAAAAADPRLFQPRATLEEAVERFKRIP
HHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
GIGDWTAQYIALRAVRETDAFPSADVALLRALTGEDGVRPSPDEALRRSAAWSPWRAYAA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHH
QHLWAADAARPGPTPHLSRSSSRQRDDDAPTAAFAHGPRPHAHRLDAGRL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]