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The map label for this gene is tpiA

Identifier: 108760209

GI number: 108760209

Start: 3289371

End: 3290141

Strand: Direct

Name: tpiA

Synonym: MXAN_2817

Alternate gene names: 108760209

Gene position: 3289371-3290141 (Clockwise)

Preceding gene: 108757102

Following gene: 108761254

Centisome position: 35.99

GC content: 71.34

Gene sequence:

>771_bases
ATGGCCACCGCGCGTCGTCGGAAGATCGTTGCTGGCAACTGGAAGATGAACAAGTCGGTACCGGAGGCGCTGGCCCTGGT
GCGCGACCTGCGAGGGCAGGTGGCTTCCCTGGGGGACACCGTGGAGGTGGTGGTGGCGCCGCCGTTCGTGGCGCTGCAGC
CGCTGCATGTCGCGCTGGAAGGCGCGCCGCTGGCGCTGGCGGCGCAGAATTGTCACTGGGAGTCCTCGGGCGCCTTCACG
GGTGAGATTTCCGCGCCGATGCTGGCCGAGCTGGGGTGCGCCTACGTCATCGTGGGGCACTCCGAGCGCCGGCAGCTCTT
CGGGGACACGGACGAGCAGGTGAACAAGCGGGCGAAGGCGGTCCGCGCGGCGGGGATGACGCCCATCATCTGCGTGGGCG
AGACACTGGCCGAGCGCGAGGCGAACCAGACGCTGGCGGTGGTGGAGCGTCAGGTGCGCGGGGCGCTGGAGGGCTTCGGG
GCCAAGGAGGTGGCGGGTTTCGTGCTGGCCTACGAGCCGGTGTGGGCCATTGGGACGGGGCGCAACGCCACGGCGGCGCA
GGCGCAGGAGGTCCACGCGGCGATCCGGGGGCTGGTCGAGCGCCTGTATGACGGGGAGACGGCCGGGCGGGTGCGCATCC
AGTACGGCGGCAGCGTGAAGCCGGACAACGCCGCGGAATTGCTGGGCCAGCCGGACGTTGACGGGGCGCTTGTCGGGGGC
GCGAGCCTGAAGGCGGGCGACTTCGCGGCCATCGTCAAGGCGGCCACTTAG

Upstream 100 bases:

>100_bases
GTCCTTGGAATTCCTGGAAGGACGCGACTTGCCGGGCATCAAGGCGCTGGAGACGCGGTAGGCTCCGCGTCCGACACACC
ACACACCCCTGGGGGACACC

Downstream 100 bases:

>100_bases
AGTTGATCCTGGGGGCGGGCGGAAGATGTTGTCACCCGATCACCACTTTGGTGTAGGGTGCGCCTCCTTTTCACGGAACG
TCTGAAAGAGTCCACATGCT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALEGAPLALAAQNCHWESSGAFT
GEISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKAVRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFG
AKEVAGFVLAYEPVWAIGTGRNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGG
ASLKAGDFAAIVKAAT

Sequences:

>Translated_256_residues
MATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALEGAPLALAAQNCHWESSGAFT
GEISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKAVRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFG
AKEVAGFVLAYEPVWAIGTGRNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGG
ASLKAGDFAAIVKAAT
>Mature_255_residues
ATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALEGAPLALAAQNCHWESSGAFTG
EISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKAVRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFGA
KEVAGFVLAYEPVWAIGTGRNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGGA
SLKAGDFAAIVKAAT

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family

Homologues:

Organism=Homo sapiens, GI4507645, Length=249, Percent_Identity=44.578313253012, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI226529917, Length=249, Percent_Identity=44.578313253012, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=49.6, Blast_Score=228, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17536593, Length=249, Percent_Identity=45.3815261044177, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320255, Length=250, Percent_Identity=42.4, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572008, Length=249, Percent_Identity=45.3815261044177, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28572006, Length=249, Percent_Identity=45.3815261044177, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28572004, Length=249, Percent_Identity=45.3815261044177, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPIS_MYXXD (Q1D8I9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631034.1
- ProteinModelPortal:   Q1D8I9
- SMR:   Q1D8I9
- STRING:   Q1D8I9
- GeneID:   4103122
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2817
- TIGR:   MXAN_2817
- eggNOG:   COG0149
- HOGENOM:   HBG708281
- OMA:   DIRSVQT
- PhylomeDB:   Q1D8I9
- ProtClustDB:   PRK00042
- BioCyc:   MXAN246197:MXAN_2817-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00147_B
- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21139
- TIGRFAMs:   TIGR00419

Pfam domain/function: PF00121 TIM; SSF51351 Triophos_ismrse

EC number: =5.3.1.1

Molecular weight: Translated: 26804; Mature: 26673

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00171 TIM_1; PS51440 TIM_2

Important sites: ACT_SITE 100-100 ACT_SITE 172-172 BINDING 13-13 BINDING 15-15

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALE
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCEEEEEC
GAPLALAAQNCHWESSGAFTGEISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKA
CCCEEEEECCCCCCCCCCEECCCCCCHHHHCCEEEEEECCCHHHHHCCCCHHHHHHHHHH
VRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFGAKEVAGFVLAYEPVWAIGTG
HHHCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCEEEEECC
RNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEECC
ASLKAGDFAAIVKAAT
CCCCCCCCEEEEEECC
>Mature Secondary Structure 
ATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALE
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCEEEEEC
GAPLALAAQNCHWESSGAFTGEISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKA
CCCEEEEECCCCCCCCCCEECCCCCCHHHHCCEEEEEECCCHHHHHCCCCHHHHHHHHHH
VRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFGAKEVAGFVLAYEPVWAIGTG
HHHCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCEEEEECC
RNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEECC
ASLKAGDFAAIVKAAT
CCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA