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The map label for this gene is mrpA [H]

Identifier: 108760199

GI number: 108760199

Start: 6399790

End: 6400815

Strand: Direct

Name: mrpA [H]

Synonym: MXAN_5123

Alternate gene names: 108760199

Gene position: 6399790-6400815 (Clockwise)

Preceding gene: 108762498

Following gene: 108758595

Centisome position: 70.02

GC content: 71.83

Gene sequence:

>1026_bases
ATGACATGGGGACAGCGCGGAACCTTAGTCGGTATGTTTCAGGCCCATCAAATGAACACCCATCTCCTGCAAGCCGCGAT
GCTCGCCTGGACTCCAAGCCTGCGGGTGACACGCGCCGAAGGCGACCTCTCCAGCATCCTGCGACGCCCCGCCGGGGCCC
TGTTGGAGCAGCCGCTCCACGAGGTCCTCGGCGTGTCGCCCAAGCGCGCCCGTGAGCTGGACGCCCGCGCCCGCGAGGAC
CGCCGCGCGGTGGAGTTCATCTCCGCCAACCTCGGCGGCGAGGACGCGTCCCCCCTCCGCCTGTCCCTGGGACTGGACGA
CGGCGAGGCCAGCGCCACCGTGCTGGACCTCAACGCCATGCTGGACGGCGCCCCCCCGGTGCAGATTTCACGGCTGTCCT
CCTCGCTCAGCCACGAGATTCGCAACCCCCTCTCCTCGGTGAAGATGGCGGTGCAGACGCTGGCCCGGAACACCGGCCTC
AATGACCGGGACAAGCGGCGGCTCACCATCGCCAACCGGGAGATTCGCACCATGGAGCGCATGCTCTGGCTCCTCTCCGA
ATACGGCCGCGACACCACCCCGAAGCTGGACGCCCATCCGCTGCGCGGCGTGGTGCAGGAGGCCACGGAGATGGTGGCCC
CCGAGCTGGCCGAACGGCGCGTGGAGGTCCGCGTGGACGAGGAACCCGACCTGCCCCGCGTCCGGGTGGACCCGACGCGG
CTGCGGCCCGTGCTGGCCCAGGTGCTGCTCAACGTCGCCATGGGCCAGGCGGAGGGCAGCCCGATGGAGGTGGCCCTGCG
CCGGGGTGGCCCCCACCAGGTGATGATGGTGCTCCACGACCCCGCCGCCGCCCTGCCCCCCGAGGAGAACGGTTCGCTCT
TCGAGCCCTTCGGCTCCCGGCTGGCCCGGGGCGCCGGTCTGTCCCTGGCCGCCCTGCGCCGGGTGATGACGGGCGTGGGG
GGAGACGTGGCCGCCCGGGGCAGCGCCGAGCCGGGCGTGGTGCTGACGCTGACGTTCGCCACCTGA

Upstream 100 bases:

>100_bases
TTCCCGAGGTACTTGGACCAGACGAGTTCGTAAACGAGCGCAGTGCCCCCGGACAGGAAGAGGAGGCAGGCCACAAGGTT
CTTAGGAAAACGCGCCGGAG

Downstream 100 bases:

>100_bases
GAGCGCCATGGAGACCCTTCTCATCGTCGACGACGACGTCTCGCTCCTCGAAACGCTGAAGATGCATTTCGAGGAGATCG
AGCAGGACGGCCAGCCCCGC

Product: sensor histidine kinase MrpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTWGQRGTLVGMFQAHQMNTHLLQAAMLAWTPSLRVTRAEGDLSSILRRPAGALLEQPLHEVLGVSPKRARELDARARED
RRAVEFISANLGGEDASPLRLSLGLDDGEASATVLDLNAMLDGAPPVQISRLSSSLSHEIRNPLSSVKMAVQTLARNTGL
NDRDKRRLTIANREIRTMERMLWLLSEYGRDTTPKLDAHPLRGVVQEATEMVAPELAERRVEVRVDEEPDLPRVRVDPTR
LRPVLAQVLLNVAMGQAEGSPMEVALRRGGPHQVMMVLHDPAAALPPEENGSLFEPFGSRLARGAGLSLAALRRVMTGVG
GDVAARGSAEPGVVLTLTFAT

Sequences:

>Translated_341_residues
MTWGQRGTLVGMFQAHQMNTHLLQAAMLAWTPSLRVTRAEGDLSSILRRPAGALLEQPLHEVLGVSPKRARELDARARED
RRAVEFISANLGGEDASPLRLSLGLDDGEASATVLDLNAMLDGAPPVQISRLSSSLSHEIRNPLSSVKMAVQTLARNTGL
NDRDKRRLTIANREIRTMERMLWLLSEYGRDTTPKLDAHPLRGVVQEATEMVAPELAERRVEVRVDEEPDLPRVRVDPTR
LRPVLAQVLLNVAMGQAEGSPMEVALRRGGPHQVMMVLHDPAAALPPEENGSLFEPFGSRLARGAGLSLAALRRVMTGVG
GDVAARGSAEPGVVLTLTFAT
>Mature_340_residues
TWGQRGTLVGMFQAHQMNTHLLQAAMLAWTPSLRVTRAEGDLSSILRRPAGALLEQPLHEVLGVSPKRARELDARAREDR
RAVEFISANLGGEDASPLRLSLGLDDGEASATVLDLNAMLDGAPPVQISRLSSSLSHEIRNPLSSVKMAVQTLARNTGLN
DRDKRRLTIANREIRTMERMLWLLSEYGRDTTPKLDAHPLRGVVQEATEMVAPELAERRVEVRVDEEPDLPRVRVDPTRL
RPVLAQVLLNVAMGQAEGSPMEVALRRGGPHQVMMVLHDPAAALPPEENGSLFEPFGSRLARGAGLSLAALRRVMTGVGG
DVAARGSAEPGVVLTLTFAT

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=211, Percent_Identity=24.1706161137441, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=23.2227488151659, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37056; Mature: 36925

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWGQRGTLVGMFQAHQMNTHLLQAAMLAWTPSLRVTRAEGDLSSILRRPAGALLEQPLH
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCHHHHHHHHHHH
EVLGVSPKRARELDARAREDRRAVEFISANLGGEDASPLRLSLGLDDGEASATVLDLNAM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEHHH
LDGAPPVQISRLSSSLSHEIRNPLSSVKMAVQTLARNTGLNDRDKRRLTIANREIRTMER
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
MLWLLSEYGRDTTPKLDAHPLRGVVQEATEMVAPELAERRVEVRVDEEPDLPRVRVDPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECHHH
LRPVLAQVLLNVAMGQAEGSPMEVALRRGGPHQVMMVLHDPAAALPPEENGSLFEPFGSR
HHHHHHHHHHHHHHCCCCCCCCEEHEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHH
LARGAGLSLAALRRVMTGVGGDVAARGSAEPGVVLTLTFAT
HHHCCCCHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TWGQRGTLVGMFQAHQMNTHLLQAAMLAWTPSLRVTRAEGDLSSILRRPAGALLEQPLH
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCHHHHHHHHHHH
EVLGVSPKRARELDARAREDRRAVEFISANLGGEDASPLRLSLGLDDGEASATVLDLNAM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEHHH
LDGAPPVQISRLSSSLSHEIRNPLSSVKMAVQTLARNTGLNDRDKRRLTIANREIRTMER
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
MLWLLSEYGRDTTPKLDAHPLRGVVQEATEMVAPELAERRVEVRVDEEPDLPRVRVDPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECHHH
LRPVLAQVLLNVAMGQAEGSPMEVALRRGGPHQVMMVLHDPAAALPPEENGSLFEPFGSR
HHHHHHHHHHHHHHCCCCCCCCEEHEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHH
LARGAGLSLAALRRVMTGVGGDVAARGSAEPGVVLTLTFAT
HHHCCCCHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]