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The map label for this gene is thiD [H]

Identifier: 108760113

GI number: 108760113

Start: 6358352

End: 6359092

Strand: Reverse

Name: thiD [H]

Synonym: MXAN_5085

Alternate gene names: 108760113

Gene position: 6359092-6358352 (Counterclockwise)

Preceding gene: 108762652

Following gene: 108763197

Centisome position: 69.58

GC content: 77.6

Gene sequence:

>741_bases
GTGAGTCCCCGCGTCCTCCTGCTGGCGGGGTTGGAGCCCACGGGACGGGCGGGGCTCTTGGCGGATGTCGCCGCGGTGCG
CGCGCTGCGGGGCCAGCCGGTGGCGGTGCCCACCGCGCAGACGGCGCAGGGTGTCCGCACCTTCACCTGGACGGCCTCGC
CGCCGCGCGTGCTGTCCGCGCAGGTGGCCGCCGCGCGCGAGCTGGGGCCGGTGCACGCGGTGAAGTGCGGCATGGTGCCC
GCGCGCGCGCAGCTCGAGGCCGCGCAGCGGGCCCTGGAGGACACGGGCGCGTGGTGGGTGGTGGACCCGGTGGTGCGCAC
CTCCCGGGGCGAGCCGCTGACGCGCCTGTCCGCACGGGCCTACCTGTCTCTGGCCGGGCCGCGCGTGGTGCTCACGCCGA
ACCTGGATGAAGCGGGCTGGCTGCTGGGACGCCCCGTCGCGCGCACGGTGGAAGAGGCTGTCGAGGCCGCGGAGGCACTG
GCGCAGCACGGCTTTGGCGCGGTGCTGGTGAAGGGCGGGCACTTGCCGGACACGCAGGGGTTGGCGGACGTCCTGGCCAC
ACCGGGCCGCGTGCGAGTGCTGGAGGGCAAGAGGCTGGCACGCGCCCCCGGACGCCGGGGCACGGGGTGCCGGCTGGCCT
CCGCGCTGGCCACGGAGCTGGGCCGGGGCCGCGCGCTGGAGACGGCGGTGCGTTCGGCCCGCGCGCTGGTGCTGCGCTAC
CTGCGGACCGGCGCGGAGTAG

Upstream 100 bases:

>100_bases
CCGTGGGCGTGCAGTGGCACCCCGAATACATGTCCACGACCATTCCGGTGCACGTGGGGCTCTACAAGGCGTTCGTGCAG
AAGGCGCGCGAGCATCGCCG

Downstream 100 bases:

>100_bases
GGCGGGCCCGCTGCTCCTGCGAACCGGCAGGGGCGGGTGCGAGGTGCACCGCACCCGCGCGAACACGGAGGGCTGCTACT
CGCTCCGCGACCGGCTCTCG

Product: putative phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSAQVAAARELGPVHAVKCGMVP
ARAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARAYLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEAL
AQHGFGAVLVKGGHLPDTQGLADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRY
LRTGAE

Sequences:

>Translated_246_residues
MSPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSAQVAAARELGPVHAVKCGMVP
ARAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARAYLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEAL
AQHGFGAVLVKGGHLPDTQGLADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRY
LRTGAE
>Mature_245_residues
SPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSAQVAAARELGPVHAVKCGMVPA
RAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARAYLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEALA
QHGFGAVLVKGGHLPDTQGLADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRYL
RTGAE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=221, Percent_Identity=36.1990950226244, Blast_Score=88, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325378, Length=258, Percent_Identity=27.906976744186, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324997, Length=245, Percent_Identity=32.6530612244898, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324517, Length=244, Percent_Identity=30.7377049180328, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 25749; Mature: 25618

Theoretical pI: Translated: 11.75; Mature: 11.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSA
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCHHHHH
QVAAARELGPVHAVKCGMVPARAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARA
HHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCHHHHHHHH
YLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEALAQHGFGAVLVKGGHLPDTQG
HEEECCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRY
HHHHHCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LRTGAE
HHHCCC
>Mature Secondary Structure 
SPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSA
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCHHHHH
QVAAARELGPVHAVKCGMVPARAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARA
HHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCHHHHHHHH
YLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEALAQHGFGAVLVKGGHLPDTQG
HEEECCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRY
HHHHHCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LRTGAE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]