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The map label for this gene is macA [H]

Identifier: 108759744

GI number: 108759744

Start: 5155765

End: 5157213

Strand: Direct

Name: macA [H]

Synonym: MXAN_4200

Alternate gene names: 108759744

Gene position: 5155765-5157213 (Clockwise)

Preceding gene: 108759408

Following gene: 108758934

Centisome position: 56.41

GC content: 71.57

Gene sequence:

>1449_bases
GTGAGCAAGACGAAAAAGTGGATCATCTCAGGCAGCGCGGCGCTCCTTCTCGGCGCGGGCGTGTACGTCACCCAGCGCGG
CGAGGAGCCCAAGACGAACGAGCGCTCGGCGGCGGTGGCCGTGGTGGAGCGCCGGGACATGGAAGTGGTGGCCGAATCCG
CGGGCCTGGTGGAGCCGCTGCGCGTCGTGGAGGTGAAGTCCCAGGCCTCCGGTGAAGTGCTGAAGGTCCACTACGACACG
GGCGACACCGTTGCCGAGGGCACGCTGCTGGCGGAAATCGAGCCGCGCGACGTGCAGAACGCGCTGGCGCAGGCCCAGGC
CGACCTGGAGTCCGCGCGGGTGCGGCTGAACACGACGGAGGCCCAGCGCCAGCGCATGGAGGCGCTGCGCAAGGACGGCT
ACGTCACGCAGCAGGAATACGAGACGGCCGTGGACGCGTCCGCGACGGCACGGGCCACCAAGGTGCGGGCGGAGACGAAC
CTCCAGTTGGCGCGTGAGCGCAGCCGGGACGTCACCATCCTCGCACGCAGCCCCGGCACCATCCTGGAGCGGACCATCCA
GCCGGGCGTCATCATCGCCTCCGCCACCAACAACGTGTCCGGTGGCACCGCGCTGTTCAAGATGGCGGACCTGTCGGTGA
TGCAGGTGCGCGCCAAGGTGGACGAGACGGACGTCGGGCAGATCAAGCCCGGCCAGAAGGCGCGCGTCACCATGGAGGCC
TACCCGGGCCGCACCTTCATCGGCGAGGTGGTGAAGATTGAACCGCAGGCCCTGGTGGAGCAGAACGTCACCCTCTTCCC
GGTGCTGGTGCGGATGGACAACCCGGACGGCCTGCTGCGGCCGGGCATGAACGCGGAAGTGGCCATTGAAATCTCCCGCC
GCCGCAATGCCCTCACCGTGCCCAACACCGCGGTGGTGGGCGTGCGGGATGCCCGGAGCGCCGCCGCCGCGGTGGGTGTT
TCCGAGGAAGCGCTGCGCGCGGTGATGCGGCCGCCGGGAGCCCCGAACCGCCCGGGCGCGCCGTCCGGACCGACGACGGT
GTCGGCCGTGGGAGAAGCCGGCGTGGGCGCCACCGCCGCGGTGGCCAATGGCGCCGGGCCGGGCGCGGTGCCCGCGAGGG
GCCAGGGCGGCATGGGTGAAGGCCAGGGCGGCGGAGGCCAGGGCCGCGCGGGCCGCCGGGCGCGCGAGGATGTCCAGGGC
GCGACGGATACGCGGCAGGGCGTCGTCTTCGTGCAGAGCCCCACCGGTCCGCAGCCCCGGCGCGTCACCCTGGGCCTGAG
TGACTGGGAGAGCACGGAAGTGGTGAGTGGCCTGGAGGATGGCGAAAAGGTGGTGCTCATCACGGTGGCGAAGCTCCAGA
AGCAGCAGCAGCAGAACACCGAGCGGATGCGCCAGATGTCAGGCGGCGTGATTCCCGGCGCGGGTGGTGGCCCGCGCGGG
CCGCGCTAA

Upstream 100 bases:

>100_bases
GGTGCTGTTCCTGAAGGACGGCGTCATCGAGCGGGACGAGCGGAATCGGGACTGAATATTCGCCACGCTCGCTGCGTGGG
CCAGGGAACGGGAGGTCGTC

Downstream 100 bases:

>100_bases
CCCCAGCCCCATCAGGAGGACACGTCATGGGTGAAATCATCCGGGTCGCATTCGATGCGGTCCTCGCCAACAAGCTGCGG
TCGCTGCTGACCATGTTGGG

Product: putative macrolide-specific efflux protein MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSKTKKWIISGSAALLLGAGVYVTQRGEEPKTNERSAAVAVVERRDMEVVAESAGLVEPLRVVEVKSQASGEVLKVHYDT
GDTVAEGTLLAEIEPRDVQNALAQAQADLESARVRLNTTEAQRQRMEALRKDGYVTQQEYETAVDASATARATKVRAETN
LQLARERSRDVTILARSPGTILERTIQPGVIIASATNNVSGGTALFKMADLSVMQVRAKVDETDVGQIKPGQKARVTMEA
YPGRTFIGEVVKIEPQALVEQNVTLFPVLVRMDNPDGLLRPGMNAEVAIEISRRRNALTVPNTAVVGVRDARSAAAAVGV
SEEALRAVMRPPGAPNRPGAPSGPTTVSAVGEAGVGATAAVANGAGPGAVPARGQGGMGEGQGGGGQGRAGRRAREDVQG
ATDTRQGVVFVQSPTGPQPRRVTLGLSDWESTEVVSGLEDGEKVVLITVAKLQKQQQQNTERMRQMSGGVIPGAGGGPRG
PR

Sequences:

>Translated_482_residues
MSKTKKWIISGSAALLLGAGVYVTQRGEEPKTNERSAAVAVVERRDMEVVAESAGLVEPLRVVEVKSQASGEVLKVHYDT
GDTVAEGTLLAEIEPRDVQNALAQAQADLESARVRLNTTEAQRQRMEALRKDGYVTQQEYETAVDASATARATKVRAETN
LQLARERSRDVTILARSPGTILERTIQPGVIIASATNNVSGGTALFKMADLSVMQVRAKVDETDVGQIKPGQKARVTMEA
YPGRTFIGEVVKIEPQALVEQNVTLFPVLVRMDNPDGLLRPGMNAEVAIEISRRRNALTVPNTAVVGVRDARSAAAAVGV
SEEALRAVMRPPGAPNRPGAPSGPTTVSAVGEAGVGATAAVANGAGPGAVPARGQGGMGEGQGGGGQGRAGRRAREDVQG
ATDTRQGVVFVQSPTGPQPRRVTLGLSDWESTEVVSGLEDGEKVVLITVAKLQKQQQQNTERMRQMSGGVIPGAGGGPRG
PR
>Mature_481_residues
SKTKKWIISGSAALLLGAGVYVTQRGEEPKTNERSAAVAVVERRDMEVVAESAGLVEPLRVVEVKSQASGEVLKVHYDTG
DTVAEGTLLAEIEPRDVQNALAQAQADLESARVRLNTTEAQRQRMEALRKDGYVTQQEYETAVDASATARATKVRAETNL
QLARERSRDVTILARSPGTILERTIQPGVIIASATNNVSGGTALFKMADLSVMQVRAKVDETDVGQIKPGQKARVTMEAY
PGRTFIGEVVKIEPQALVEQNVTLFPVLVRMDNPDGLLRPGMNAEVAIEISRRRNALTVPNTAVVGVRDARSAAAAVGVS
EEALRAVMRPPGAPNRPGAPSGPTTVSAVGEAGVGATAAVANGAGPGAVPARGQGGMGEGQGGGGQGRAGRRAREDVQGA
TDTRQGVVFVQSPTGPQPRRVTLGLSDWESTEVVSGLEDGEKVVLITVAKLQKQQQQNTERMRQMSGGVIPGAGGGPRGP
R

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=276, Percent_Identity=28.6231884057971, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50648; Mature: 50517

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTKKWIISGSAALLLGAGVYVTQRGEEPKTNERSAAVAVVERRDMEVVAESAGLVEPL
CCCCCEEEEECCCEEEEECCEEEEECCCCCCCCCCCCEEEEEHHCCHHHHHHHCCCCCCC
RVVEVKSQASGEVLKVHYDTGDTVAEGTLLAEIEPRDVQNALAQAQADLESARVRLNTTE
CEEEECCCCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHHHHHHHHHHHCEEEEECHH
AQRQRMEALRKDGYVTQQEYETAVDASATARATKVRAETNLQLARERSRDVTILARSPGT
HHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHEEEECCCCHHHHHHCCCCEEEEECCCCH
ILERTIQPGVIIASATNNVSGGTALFKMADLSVMQVRAKVDETDVGQIKPGQKARVTMEA
HHHHCCCCCEEEEECCCCCCCCEEEEEHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
YPGRTFIGEVVKIEPQALVEQNVTLFPVLVRMDNPDGLLRPGMNAEVAIEISRRRNALTV
CCCCHHCCCEEEECHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEC
PNTAVVGVRDARSAAAAVGVSEEALRAVMRPPGAPNRPGAPSGPTTVSAVGEAGVGATAA
CCEEEEEECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHE
VANGAGPGAVPARGQGGMGEGQGGGGQGRAGRRAREDVQGATDTRQGVVFVQSPTGPQPR
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCC
RVTLGLSDWESTEVVSGLEDGEKVVLITVAKLQKQQQQNTERMRQMSGGVIPGAGGGPRG
EEEEECCCCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PR
CC
>Mature Secondary Structure 
SKTKKWIISGSAALLLGAGVYVTQRGEEPKTNERSAAVAVVERRDMEVVAESAGLVEPL
CCCCEEEEECCCEEEEECCEEEEECCCCCCCCCCCCEEEEEHHCCHHHHHHHCCCCCCC
RVVEVKSQASGEVLKVHYDTGDTVAEGTLLAEIEPRDVQNALAQAQADLESARVRLNTTE
CEEEECCCCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHHHHHHHHHHHCEEEEECHH
AQRQRMEALRKDGYVTQQEYETAVDASATARATKVRAETNLQLARERSRDVTILARSPGT
HHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHEEEECCCCHHHHHHCCCCEEEEECCCCH
ILERTIQPGVIIASATNNVSGGTALFKMADLSVMQVRAKVDETDVGQIKPGQKARVTMEA
HHHHCCCCCEEEEECCCCCCCCEEEEEHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
YPGRTFIGEVVKIEPQALVEQNVTLFPVLVRMDNPDGLLRPGMNAEVAIEISRRRNALTV
CCCCHHCCCEEEECHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEC
PNTAVVGVRDARSAAAAVGVSEEALRAVMRPPGAPNRPGAPSGPTTVSAVGEAGVGATAA
CCEEEEEECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHE
VANGAGPGAVPARGQGGMGEGQGGGGQGRAGRRAREDVQGATDTRQGVVFVQSPTGPQPR
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCC
RVTLGLSDWESTEVVSGLEDGEKVVLITVAKLQKQQQQNTERMRQMSGGVIPGAGGGPRG
EEEEECCCCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]