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The map label for this gene is butA [H]

Identifier: 108759251

GI number: 108759251

Start: 556423

End: 557010

Strand: Reverse

Name: butA [H]

Synonym: MXAN_0499

Alternate gene names: 108759251

Gene position: 557010-556423 (Counterclockwise)

Preceding gene: 108757939

Following gene: 108759271

Centisome position: 6.09

GC content: 64.97

Gene sequence:

>588_bases
TTGAACCGATGTCCACCGGGGAGGGCCCACCGTCGCTCGCCACGGATGGACCCGTTTACTTCGGAGCACCTAGGGGATGA
CGGTGATGCTCAGGTCCGCGGTGTTGGTCGCATCATTGATGTCCACCGCGACCCGGTGGCATCCACGAAGGTGGTGATGA
TCCCAATGCTCAGCGGCTGCAAGACCACCGTCACGGTCAAGCTGGCGCTCGCGCCCAATGCCCCCAGATCACAGCCTACC
GCCGAACCGTTGCGTTGGCAGCTTCCCTGCGAGGACGTCACAGAGACGAAGGTCGCCGCGTCGGAGCTCGGGCGGCATGG
AATCCGGGTGAATGTGGTGGCCCCTGGAGCCATCCAGACACCGCTGGCGGAGAGTGTCGGACTCATCGAGGTCATGGGTC
ATGAGTTCCTGGCTCGCACGCCGCTGGGCAAGCCGTGTGGAATGCCGTCGGATGTCGCGGGCGTGGTCTCCTTCCTGTGC
GGCGAGGACGCGGCGTGGATCACCGGGGAGACCCTCTCCGTCGATGGTGGAAACCACATCCGTGGCCTGCACAGCTACTG
GGACATGCTGAGCCGCGCCGCGAAGTAG

Upstream 100 bases:

>100_bases
AGCAATGCGGCTGTTCTCAACCCCCTTCGCACCTTGGATTCCAGTCTCACCGACGGCCTCGCTGACCAGGGGGAATAGGA
GCCCCCGGTGGACATCGGAC

Downstream 100 bases:

>100_bases
CAGCGCGGCTCTGAGTCGCGCGGCTACATCACGAGAAGCAGTCGAAGGACAGGCTCATACCCCATCGGGTCCCTGCGGAG
GTTGGCGACCGGTGGCGAGA

Product: hypothetical protein

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGCKTTVTVKLALAPNAPRSQPT
AEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQTPLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLC
GEDAAWITGETLSVDGGNHIRGLHSYWDMLSRAAK

Sequences:

>Translated_195_residues
MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGCKTTVTVKLALAPNAPRSQPT
AEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQTPLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLC
GEDAAWITGETLSVDGGNHIRGLHSYWDMLSRAAK
>Mature_195_residues
MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGCKTTVTVKLALAPNAPRSQPT
AEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQTPLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLC
GEDAAWITGETLSVDGGNHIRGLHSYWDMLSRAAK

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=82, Percent_Identity=47.5609756097561, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI32483357, Length=83, Percent_Identity=44.578313253012, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=85, Percent_Identity=41.1764705882353, Blast_Score=60, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21355319, Length=82, Percent_Identity=43.9024390243902, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 20875; Mature: 20875

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGC
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEECCEEEECCCCCCCCCEEEEEECCCCC
KTTVTVKLALAPNAPRSQPTAEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQT
CEEEEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCC
PLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLCGEDAAWITGETLSVDGGNHI
CHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCCCC
RGLHSYWDMLSRAAK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGC
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEECCEEEECCCCCCCCCEEEEEECCCCC
KTTVTVKLALAPNAPRSQPTAEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQT
CEEEEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCC
PLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLCGEDAAWITGETLSVDGGNHI
CHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCCCC
RGLHSYWDMLSRAAK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA