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The map label for this gene is glmS [H]

Identifier: 108757939

GI number: 108757939

Start: 558607

End: 560517

Strand: Reverse

Name: glmS [H]

Synonym: MXAN_0501

Alternate gene names: 108757939

Gene position: 560517-558607 (Counterclockwise)

Preceding gene: 108763736

Following gene: 108759251

Centisome position: 6.13

GC content: 67.24

Gene sequence:

>1911_bases
ATGTGCGGCATCGTCGGCGCGGTTTCCCAGCGCAACATCGTTCCCATCCTCGTCCAGGGCCTGCAGCGCCTTGAGTACCG
TGGCTATGACTCCTGCGGCGTGGCCGTGCACGAGGCCAGCATGGGCAACAACCCCATGGGCGGCCTGCACCGCGCACGCA
GCACGGCGCGCGTGGCCGAGCTGCAGGCGCAGGTCGATGCCGAACATCTGCAGGGCGCGACCGGCATCGCCCACACGCGC
TGGGCCACGCATGGTGCGCCGGCGGTGCACAACGCGCACCCGCATTTCAGCCACGGCCCCAACGCCGCGCCTGCCGAGAC
CGACCGCGCTGGCCGCGTCGCGCTGGTGCACAACGGCATCATCGAGAACCACCAGGAGCTGCGCCGCATGCTGCAGGCGC
GTGGCTATGCGTTCTCGAGCCAGACCGACACCGAGGTCATCGCGCATCTGGTCGACAGCCTGTATGACGGCGACCTGTTC
GACGCCGTGAAGGCGGCCGTCGCGCAACTGCACGGGGCCTATGCGATCGCGGTGATGCACAAGGACGAACCGCACCGCGT
GGTCGGCGCGCGCGCCGGATCGCCGCTGGTGCTGGGCGTGGGCGTGGGCGAGAACTTCCTCGCGAGCGACGCGATGGCGC
TGGCGGGCGTGACCGACCAGGTCGTCTATCTGAAGGAGGGCGATCTCGTCGACCTGCAGCCCGGCCGCTACTGGCTCGTC
GATCACGACGGCCAGCGATTGAGCGAGGCACAGCGCCCCGTGCGCACCGTACACGCACACAGCGGCGCGGCCGAGCTGGG
TCCCTACCGCCACTACATGCAGAAGGAAATCTTCGAGCAGCCACGTGCGATCGCCGACACGCTCGAGGGAGTGCAGGGCA
TCGTGCCCGAGCTGTTCGACGGCCTTGATGCCGACGGCAGCACCCGCACAGCCGCGTGGCGCGTGTTCAAGGAAATCGAC
TCGGTGCTGATCCTCGCCTGCGGCACCAGCTACTACAGCGGCTGCGCGGCCAAGTACTGGATCGAGGCCATCGCGAAGCT
CACGTGCAACGTCGAAGTCGCCAGCGAATACCGCTACCGCACCAGCGTGCCGAACCCGAAGACGCTGGTAGTCACCATCA
GTCAATCCGGCGAAACGGCAGACACCCTGGCCGCGCTGCGCCATGCGCAGAGACTGGGCATGACGCACACGCTCACCGTC
TGCAACGTGGCCACCAGCGCCATGGTGCGCGAATGCGAGCTGGCCTACATCACGCGCGCCGGCGTCGAGATCGGCGTGGC
CTCCACCAAGGCGTTCACCACGCAGTTGGCGGGCCTGTTCCTGCTCACGCTCGCGCTCGCGCAATCCAAGGGCCACCTGA
GCCAGGAGCAGGAAGCGCAATACCTCACCTCCATGCGCCATCTGCCCGTCGCACTGCAGGCCGTGCTCGCACTCGAGCCG
CAGGTCATCAGCTGGGCCGAAGATTTCGCGAAGATGGAAAATGCGCTGTTCCTCGGGCGCGGCATCCACTACCCGATCGC
GCTCGAAGGCGCGCTCAAGCTCAAGGAAATCAGCTACATCCACGCCGAGGCCTACCCCGCAGGCGAGCTCAAGCACGGCC
CGCTCGCGCTGGTCACCAGCAGCATGCCGGTGGTCACCGTCGCGCCGCACGACGAGTTGCTCGAAAAGCTCAAGAACAAC
ATGCAGGAAGTGCGCGCGCGCGGCGGCGTGCTCTACGTGCTGGCCGACGGCGACTCGCAGATCGAAAGCGAAGACGGCAT
CCACGTGATCCGCATGCCCGAGCACTACGGCGCGTTGAGCCCGATTTTGCACGTCGTGCCGCTGCAACTGCTCGCCTACC
ACACGGCCGTCGCACGCGGCACGGACGTGGACAAGCCGCGCAATCTGGCGAAGTCTTTGACCGTGGAGTGA

Upstream 100 bases:

>100_bases
AAATCGCTCTGCGCACCATCGCTGACATTCGGGGGCGCAGCACGGCCCCATGGTTCAGCAGTCGGAAGATTCGGATCTGC
CCCCAGTAGGAGCAATCACC

Downstream 100 bases:

>100_bases
GGGGCTGGAGGGAGTGTTCGACGGTGCTCCCGGCAAGGTGGCAGTGACAGCGCCAAACTGAAGAGCCGCCATTGCGACCG
TTGACTTCAGAGGGATGGGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MCGIVGAVSQRNIVPILVQGLQRLEYRGYDSCGVAVHEASMGNNPMGGLHRARSTARVAELQAQVDAEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPNAAPAETDRAGRVALVHNGIIENHQELRRMLQARGYAFSSQTDTEVIAHLVDSLYDGDLF
DAVKAAVAQLHGAYAIAVMHKDEPHRVVGARAGSPLVLGVGVGENFLASDAMALAGVTDQVVYLKEGDLVDLQPGRYWLV
DHDGQRLSEAQRPVRTVHAHSGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFDGLDADGSTRTAAWRVFKEID
SVLILACGTSYYSGCAAKYWIEAIAKLTCNVEVASEYRYRTSVPNPKTLVVTISQSGETADTLAALRHAQRLGMTHTLTV
CNVATSAMVRECELAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQSKGHLSQEQEAQYLTSMRHLPVALQAVLALEP
QVISWAEDFAKMENALFLGRGIHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPHDELLEKLKNN
MQEVRARGGVLYVLADGDSQIESEDGIHVIRMPEHYGALSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSLTVE

Sequences:

>Translated_636_residues
MCGIVGAVSQRNIVPILVQGLQRLEYRGYDSCGVAVHEASMGNNPMGGLHRARSTARVAELQAQVDAEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPNAAPAETDRAGRVALVHNGIIENHQELRRMLQARGYAFSSQTDTEVIAHLVDSLYDGDLF
DAVKAAVAQLHGAYAIAVMHKDEPHRVVGARAGSPLVLGVGVGENFLASDAMALAGVTDQVVYLKEGDLVDLQPGRYWLV
DHDGQRLSEAQRPVRTVHAHSGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFDGLDADGSTRTAAWRVFKEID
SVLILACGTSYYSGCAAKYWIEAIAKLTCNVEVASEYRYRTSVPNPKTLVVTISQSGETADTLAALRHAQRLGMTHTLTV
CNVATSAMVRECELAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQSKGHLSQEQEAQYLTSMRHLPVALQAVLALEP
QVISWAEDFAKMENALFLGRGIHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPHDELLEKLKNN
MQEVRARGGVLYVLADGDSQIESEDGIHVIRMPEHYGALSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSLTVE
>Mature_636_residues
MCGIVGAVSQRNIVPILVQGLQRLEYRGYDSCGVAVHEASMGNNPMGGLHRARSTARVAELQAQVDAEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPNAAPAETDRAGRVALVHNGIIENHQELRRMLQARGYAFSSQTDTEVIAHLVDSLYDGDLF
DAVKAAVAQLHGAYAIAVMHKDEPHRVVGARAGSPLVLGVGVGENFLASDAMALAGVTDQVVYLKEGDLVDLQPGRYWLV
DHDGQRLSEAQRPVRTVHAHSGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFDGLDADGSTRTAAWRVFKEID
SVLILACGTSYYSGCAAKYWIEAIAKLTCNVEVASEYRYRTSVPNPKTLVVTISQSGETADTLAALRHAQRLGMTHTLTV
CNVATSAMVRECELAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQSKGHLSQEQEAQYLTSMRHLPVALQAVLALEP
QVISWAEDFAKMENALFLGRGIHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPHDELLEKLKNN
MQEVRARGGVLYVLADGDSQIESEDGIHVIRMPEHYGALSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSLTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=705, Percent_Identity=34.8936170212766, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI205277386, Length=703, Percent_Identity=34.1394025604552, Blast_Score=384, Evalue=1e-106,
Organism=Escherichia coli, GI1790167, Length=643, Percent_Identity=51.3219284603421, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1788651, Length=274, Percent_Identity=25.1824817518248, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=443, Percent_Identity=37.020316027088, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17532899, Length=437, Percent_Identity=37.070938215103, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17532897, Length=440, Percent_Identity=36.5909090909091, Blast_Score=264, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=446, Percent_Identity=33.6322869955157, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=28.9954337899543, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=220, Percent_Identity=33.6363636363636, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357745, Length=725, Percent_Identity=34.2068965517241, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI28573187, Length=268, Percent_Identity=26.4925373134328, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24659598, Length=211, Percent_Identity=27.4881516587678, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24659604, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68789; Mature: 68789

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSQRNIVPILVQGLQRLEYRGYDSCGVAVHEASMGNNPMGGLHRARSTARVAE
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LQAQVDAEHLQGATGIAHTRWATHGAPAVHNAHPHFSHGPNAAPAETDRAGRVALVHNGI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCH
IENHQELRRMLQARGYAFSSQTDTEVIAHLVDSLYDGDLFDAVKAAVAQLHGAYAIAVMH
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEE
KDEPHRVVGARAGSPLVLGVGVGENFLASDAMALAGVTDQVVYLKEGDLVDLQPGRYWLV
CCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCEEEEE
DHDGQRLSEAQRPVRTVHAHSGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFD
ECCCHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
GLDADGSTRTAAWRVFKEIDSVLILACGTSYYSGCAAKYWIEAIAKLTCNVEVASEYRYR
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHCCHHHHHHHHHHHHHHCCEEECCCCCEE
TSVPNPKTLVVTISQSGETADTLAALRHAQRLGMTHTLTVCNVATSAMVRECELAYITRA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHEEECC
GVEIGVASTKAFTTQLAGLFLLTLALAQSKGHLSQEQEAQYLTSMRHLPVALQAVLALEP
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
QVISWAEDFAKMENALFLGRGIHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTS
HHHHHHHHHHHHHHHEEECCCCCCCEEECCCEEHHHHHEEEECCCCCCCCCCCCEEEEEC
SMPVVTVAPHDELLEKLKNNMQEVRARGGVLYVLADGDSQIESEDGIHVIRMPEHYGALS
CCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHH
PILHVVPLQLLAYHTAVARGTDVDKPRNLAKSLTVE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSQRNIVPILVQGLQRLEYRGYDSCGVAVHEASMGNNPMGGLHRARSTARVAE
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LQAQVDAEHLQGATGIAHTRWATHGAPAVHNAHPHFSHGPNAAPAETDRAGRVALVHNGI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCH
IENHQELRRMLQARGYAFSSQTDTEVIAHLVDSLYDGDLFDAVKAAVAQLHGAYAIAVMH
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEE
KDEPHRVVGARAGSPLVLGVGVGENFLASDAMALAGVTDQVVYLKEGDLVDLQPGRYWLV
CCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCEEEEE
DHDGQRLSEAQRPVRTVHAHSGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFD
ECCCHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
GLDADGSTRTAAWRVFKEIDSVLILACGTSYYSGCAAKYWIEAIAKLTCNVEVASEYRYR
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHCCHHHHHHHHHHHHHHCCEEECCCCCEE
TSVPNPKTLVVTISQSGETADTLAALRHAQRLGMTHTLTVCNVATSAMVRECELAYITRA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHEEECC
GVEIGVASTKAFTTQLAGLFLLTLALAQSKGHLSQEQEAQYLTSMRHLPVALQAVLALEP
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
QVISWAEDFAKMENALFLGRGIHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTS
HHHHHHHHHHHHHHHEEECCCCCCCEEECCCEEHHHHHEEEECCCCCCCCCCCCEEEEEC
SMPVVTVAPHDELLEKLKNNMQEVRARGGVLYVLADGDSQIESEDGIHVIRMPEHYGALS
CCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHH
PILHVVPLQLLAYHTAVARGTDVDKPRNLAKSLTVE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]