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The map label for this gene is lpxD [H]

Identifier: 108758832

GI number: 108758832

Start: 5919664

End: 5920728

Strand: Reverse

Name: lpxD [H]

Synonym: MXAN_4726

Alternate gene names: 108758832

Gene position: 5920728-5919664 (Counterclockwise)

Preceding gene: 108760588

Following gene: 108762744

Centisome position: 64.78

GC content: 72.3

Gene sequence:

>1065_bases
GTGCAGACCGCTCCCATGCCCCGCCAGCTCGGGGAACTCGCCGCCCACGTGGGTGGAGAGCTCCTCGGTGACCCCTCACA
GCTCATTCACGGACTCAACGGGCTTGAAGAAGCCGGCCCGGGAGACGTGTCTTTCTACGGAAACCCGCGCTATCGGCGCC
AGTTCGAGGCCACCCGTGCCTCGGCGGTGCTGGTGGGCGCCGACGTGCCCCCCCGCGAGGGCGTGGCGCTGGTCCGGGTG
GCCAACCCGCATCTGGCGTACGCGAAGCTGCTGCGCCTGTTCCATGCGCCAGAGCGTCCCGCCGCGGGCGTGAGGCCCGG
CGCCTGGGTCCATCCCGAGGCCACCGTCCATCCGGAGGCCGTGCTGCTGCCCGGCGCGTCGGTGGACCGGGGCGGACGGG
TGGGCGCGCGCACGGTGCTGTACCCGGGCGCCTACGTGGGCGAACAGGCCGAGGTGGGGGAGGACTGCGTCCTGTACCCC
AACGTCACGGTGCGCGAGCGCTGCATCGTGGGCGCGCGCGTCATCCTCCACGCTTCCAGCGTGGTGGGCGCGGACGGCTT
CGGCTTCGCCTTCAACCCGGAAGGCGAGGCGGGGCCGGAGCACTTCAAGATTCCCCAGGTCGGCATCGTCCGCATCGAGG
ACGACGTCGAGGTAGGGGCGTGCACCTGCATCGACCGCGCGACGGTGGGCGAGACCGTGGTGGGGCGCGGCGCGAAACTC
GACAACCTGGTGCAGATTGCCCACAACGTGCGAGTGGGCCCGCTGTCCCTCATCTGCGCTCAGGCCGGTGTGTCCGGCTC
GGCGGAGGTTGGGACGGGCGTGGTGCTCGCGGGGCAGGTTGGCGTGGTGGGGCACATCCGCGTCGGTGACCTGGCCAAGG
TGGGCGCGCAGTCCGGCGTCGCGCACGACGTGCCGGACGGCCAGGTGGTGAGCGGTAGCCCCGCCGTTCCCCACCGAGAG
TGGCTGCGGGCCAGCGCCGCGGCGGGCCAGATGGCGGACCTGCTCAAGGAAGTGCGCGCCCTGCGGCGCCGGGTGGAGAC
GCTGGAGAAGGAAAAGGGGCCGTGA

Upstream 100 bases:

>100_bases
CAGCACGACATCTCCAACGAGGTCATCCGGGCGTACAACAGCTCGAAGAAGACGGCGGCGAAGGACGCCCCGACGAAGAA
GTAGCCGTCACTCCCAACTC

Downstream 100 bases:

>100_bases
TGGACATCGGAGAGATTCTCAATCTGCTGCCGCATCGGTACCCGTTCCTGCTGGTGGACCGGGTGGTGGAGATCATCCCG
GGCCAGAAGCTGACGGCCTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MQTAPMPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRASAVLVGADVPPREGVALVRV
ANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEAVLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYP
NVTVRERCIVGARVILHASSVVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKL
DNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGVAHDVPDGQVVSGSPAVPHRE
WLRASAAAGQMADLLKEVRALRRRVETLEKEKGP

Sequences:

>Translated_354_residues
MQTAPMPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRASAVLVGADVPPREGVALVRV
ANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEAVLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYP
NVTVRERCIVGARVILHASSVVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKL
DNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGVAHDVPDGQVVSGSPAVPHRE
WLRASAAAGQMADLLKEVRALRRRVETLEKEKGP
>Mature_354_residues
MQTAPMPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRASAVLVGADVPPREGVALVRV
ANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEAVLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYP
NVTVRERCIVGARVILHASSVVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKL
DNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGVAHDVPDGQVVSGSPAVPHRE
WLRASAAAGQMADLLKEVRALRRRVETLEKEKGP

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=343, Percent_Identity=31.7784256559767, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786378, Length=193, Percent_Identity=26.9430051813472, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36912; Mature: 36912

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAPMPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRA
CCCCCCHHHHHHHHHHHCCHHCCCHHHHHHHHCCHHHCCCCCEEECCCCHHHHHHHHHCC
SAVLVGADVPPREGVALVRVANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEA
EEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCE
VLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYPNVTVRERCIVGARVILHASS
EEECCCCCCCCCCCCCEEEECCCCCCCCHHHCCCCEEECCCCCHHHHHHHHHHHEEEHHH
VVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKL
HCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCHHCCCHHHCCCCCH
DNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGV
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHCCCC
AHDVPDGQVVSGSPAVPHREWLRASAAAGQMADLLKEVRALRRRVETLEKEKGP
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTAPMPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRA
CCCCCCHHHHHHHHHHHCCHHCCCHHHHHHHHCCHHHCCCCCEEECCCCHHHHHHHHHCC
SAVLVGADVPPREGVALVRVANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEA
EEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCE
VLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYPNVTVRERCIVGARVILHASS
EEECCCCCCCCCCCCCEEEECCCCCCCCHHHCCCCEEECCCCCHHHHHHHHHHHEEEHHH
VVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKL
HCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCHHCCCHHHCCCCCH
DNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGV
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHCCCC
AHDVPDGQVVSGSPAVPHREWLRASAAAGQMADLLKEVRALRRRVETLEKEKGP
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA