Click here to switch to the map view.

The map label for this gene is rmd [H]

Identifier: 108758739

GI number: 108758739

Start: 6634459

End: 6635385

Strand: Direct

Name: rmd [H]

Synonym: MXAN_5328

Alternate gene names: 108758739

Gene position: 6634459-6635385 (Clockwise)

Preceding gene: 108760364

Following gene: 108762267

Centisome position: 72.59

GC content: 71.41

Gene sequence:

>927_bases
ATGCGCATTCTGGTAACAGGCGCGGATGGCTTCGTCGGCCGGCACTTGTGCGCCCTGCTGCGCGCCGCCGGCGACGAGGT
AGTGGAGGCCCACGGGCCGCGCGGTGAGGGCATCAACAGCAACGCCCTGCACTTCGACGTGGCCAATGAAGCCTCGGTGA
AGGCGGCGGTAGCCGAGGTGAAGCCCGAGGGCATCATTCATCTGGCGGGCTTCAGCTCGGTCGCGAAGAGCCACCACAAC
CCGTCCCGGGTGTTCGCGGTGAACACCATGGGCGTGGTGCACCTGCTCACCGCGGTGCGCGAGAGCGTCCCGAAGGCGCG
CGTGGTGCTGGTGGGCTCCGGCGAGGTGTACGGCCCGGTGCCCGAAGGCACGCGCGCCACCGAGGACACCCCCGCGGTGC
CCCTGAGCCCCTACGCTGCCTCCAAGTCCGCAGCAGAGCTGGCCGCGGTGCAGTTCCACCGCAGCTACGGGCTGGAGGTC
GTCATGGCGCGGCCCTTCAACCACCTGGGCGCGGGGCAGGACCCCACCTTCGTGGTGCCCTCGTTCGCGGCGCAGATTCG
CGCCATCGGGCTGGGCACGGTGGACCCGGTGCTGCGCACGGGCAACCTGGATGCGGTGCGCGACTTCTCCCACGTCCGCG
ACGTGGTGGAGGCCTACCGGCTGCTGCTCGACAAGGGTGAGCCGGGGCAGGCGTACAACATCGGCAGCGGTGAGGGCCGC
ACCATCCGCAGCCTGCTGGAGGAGATGCTGTCGCTGGCGGGTGTCAGCGCGCGCATCGAGCTGGACCCCGCGCGCCTGCG
GCCCTCCGACATCCCCAGCCTCGTCGGCGCTCCCGACAAGCTGAAGGCGCTGGGTTGGGTCCCGAAGCTGACCGTGGCGG
ACGCGCTGCGCGATGTGCTCGGCCCCCGCGTGCCCGGCGCGGCGTGA

Upstream 100 bases:

>100_bases
GAAGACGAAGCTGGGCTGGGAGCCCAAGGTCCGCTTCAAGGAGCTGGTGGAGATGATGGTGGACGCGGACCTGGAGCGCG
TGAAGGCGGGGCAGCGGTAG

Downstream 100 bases:

>100_bases
GCAAGCGAAGGCGCGCGCGTGTCCCCAAGGATGCGCGCGCGTCGGAGGCCCGGCTGGGCGACCGATGCCTCGCCAGCTTC
GATGGGACTGGCGTCGCGGG

Product: GDP-4-dehydro-6-deoxy-D-mannose reductase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRILVTGADGFVGRHLCALLRAAGDEVVEAHGPRGEGINSNALHFDVANEASVKAAVAEVKPEGIIHLAGFSSVAKSHHN
PSRVFAVNTMGVVHLLTAVRESVPKARVVLVGSGEVYGPVPEGTRATEDTPAVPLSPYAASKSAAELAAVQFHRSYGLEV
VMARPFNHLGAGQDPTFVVPSFAAQIRAIGLGTVDPVLRTGNLDAVRDFSHVRDVVEAYRLLLDKGEPGQAYNIGSGEGR
TIRSLLEEMLSLAGVSARIELDPARLRPSDIPSLVGAPDKLKALGWVPKLTVADALRDVLGPRVPGAA

Sequences:

>Translated_308_residues
MRILVTGADGFVGRHLCALLRAAGDEVVEAHGPRGEGINSNALHFDVANEASVKAAVAEVKPEGIIHLAGFSSVAKSHHN
PSRVFAVNTMGVVHLLTAVRESVPKARVVLVGSGEVYGPVPEGTRATEDTPAVPLSPYAASKSAAELAAVQFHRSYGLEV
VMARPFNHLGAGQDPTFVVPSFAAQIRAIGLGTVDPVLRTGNLDAVRDFSHVRDVVEAYRLLLDKGEPGQAYNIGSGEGR
TIRSLLEEMLSLAGVSARIELDPARLRPSDIPSLVGAPDKLKALGWVPKLTVADALRDVLGPRVPGAA
>Mature_308_residues
MRILVTGADGFVGRHLCALLRAAGDEVVEAHGPRGEGINSNALHFDVANEASVKAAVAEVKPEGIIHLAGFSSVAKSHHN
PSRVFAVNTMGVVHLLTAVRESVPKARVVLVGSGEVYGPVPEGTRATEDTPAVPLSPYAASKSAAELAAVQFHRSYGLEV
VMARPFNHLGAGQDPTFVVPSFAAQIRAIGLGTVDPVLRTGNLDAVRDFSHVRDVVEAYRLLLDKGEPGQAYNIGSGEGR
TIRSLLEEMLSLAGVSARIELDPARLRPSDIPSLVGAPDKLKALGWVPKLTVADALRDVLGPRVPGAA

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=339, Percent_Identity=27.4336283185841, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=26.1538461538462, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI42516563, Length=318, Percent_Identity=28.6163522012579, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788366, Length=355, Percent_Identity=26.4788732394366, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786974, Length=329, Percent_Identity=24.6200607902736, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI48994969, Length=331, Percent_Identity=27.7945619335347, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI133901786, Length=343, Percent_Identity=26.8221574344023, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133901788, Length=343, Percent_Identity=26.8221574344023, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539422, Length=343, Percent_Identity=26.8221574344023, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539424, Length=343, Percent_Identity=26.8221574344023, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133901790, Length=343, Percent_Identity=26.8221574344023, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17507723, Length=343, Percent_Identity=26.8221574344023, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71982038, Length=328, Percent_Identity=28.0487804878049, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=326, Percent_Identity=27.9141104294479, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=324, Percent_Identity=23.1481481481481, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17539532, Length=319, Percent_Identity=28.2131661442006, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=338, Percent_Identity=24.2603550295858, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24158427, Length=339, Percent_Identity=25.9587020648968, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=27.217125382263, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 32335; Mature: 32335

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00226 IF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVTGADGFVGRHLCALLRAAGDEVVEAHGPRGEGINSNALHFDVANEASVKAAVAEV
CEEEEECCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHC
KPEGIIHLAGFSSVAKSHHNPSRVFAVNTMGVVHLLTAVRESVPKARVVLVGSGEVYGPV
CCCCEEEECCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCEECCC
PEGTRATEDTPAVPLSPYAASKSAAELAAVQFHRSYGLEVVMARPFNHLGAGQDPTFVVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHCCCCCCCCEECC
SFAAQIRAIGLGTVDPVLRTGNLDAVRDFSHVRDVVEAYRLLLDKGEPGQAYNIGSGEGR
HHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCH
TIRSLLEEMLSLAGVSARIELDPARLRPSDIPSLVGAPDKLKALGWVPKLTVADALRDVL
HHHHHHHHHHHHCCCCEEEEECHHHCCCCCCHHHHCCCHHHHHHCCCCCHHHHHHHHHHH
GPRVPGAA
CCCCCCCC
>Mature Secondary Structure
MRILVTGADGFVGRHLCALLRAAGDEVVEAHGPRGEGINSNALHFDVANEASVKAAVAEV
CEEEEECCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHC
KPEGIIHLAGFSSVAKSHHNPSRVFAVNTMGVVHLLTAVRESVPKARVVLVGSGEVYGPV
CCCCEEEECCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCEECCC
PEGTRATEDTPAVPLSPYAASKSAAELAAVQFHRSYGLEVVMARPFNHLGAGQDPTFVVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHCCCCCCCCEECC
SFAAQIRAIGLGTVDPVLRTGNLDAVRDFSHVRDVVEAYRLLLDKGEPGQAYNIGSGEGR
HHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCH
TIRSLLEEMLSLAGVSARIELDPARLRPSDIPSLVGAPDKLKALGWVPKLTVADALRDVL
HHHHHHHHHHHHCCCCEEEEECHHHCCCCCCHHHHCCCHHHHHHCCCCCHHHHHHHHHHH
GPRVPGAA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]