Click here to switch to the map view.

The map label for this gene is crp [H]

Identifier: 108758734

GI number: 108758734

Start: 3152979

End: 3153629

Strand: Direct

Name: crp [H]

Synonym: MXAN_2702

Alternate gene names: 108758734

Gene position: 3152979-3153629 (Clockwise)

Preceding gene: 108759739

Following gene: 108760258

Centisome position: 34.5

GC content: 65.28

Gene sequence:

>651_bases
ATGGGCGCCGAGGAAACCCTCTTTCAACGTTTCGGCAAGGAGTTCCCCCAGGGCACCGAGCTCTTCCGCGAGGGAGAAGC
CGGCAAGGAGATGTTCGTCATCCAAGCAGGACGGGTGGCCATCTCCAAGCGGGTCCGTGACGTCGAGAAGGTTCTCGCCG
TCCTGGGCCCCGGTGAGTTCTTCGGGGAGATGGCCATCATTTCCAACAAGCCGCGCAATGCCTCGGCCACGGTCAACGAG
GACGCGAGGCTGCTGGTCATCGACCCCAAGACGTTCGAGGGGATGATCCGCGGCAATGCGGAGATCGCCGTCCGGATGAT
CAAGAAGCTGGCCGAACGCCTCTCCGAGGCGGACGCCCAGATCGAGAACCTGCTGCACAACGACCCGGCCAGCCGGGTGG
TGCACCAGATCATCCAGGCCTGCCAGAGCCGGGGCCGTCCCCTGGACGAGGGCGTGGAGATCGACTTCGCGATGCGGGAA
CTGCCGCGCCAGATTGGTGTGGGCGAGCCCGCGGTCCGCGCCGTGGTGGACCGGCTGGAGCGTTCCGGTCTGGTCGAGCG
GAACGGGGACCGGATGACCGTGCCGGACACGGCCAGGCTGCACGACTTCCTCCAATACCTGGAGATGAAGTGGAAGTTCG
GAGACCTCTAG

Upstream 100 bases:

>100_bases
CCCGCGCCGGTGTCTCGCGTGGCGTGGCGGCTGTCCCACCGGTGCGCACAGAAAAGGGAATTTGACCGGGCGAGTGTGGG
CTGATTGACTCCTTTGCAGG

Downstream 100 bases:

>100_bases
CGTGAAGCTGCGAGTCCTCGGCTGCCACGGCGGCGAGCTACCCAACTGCAAGAGCACCTGCTTCCTCGTCGATGACGTGC
TGGCGCTCGATGCGGGGGCG

Product: cyclic nucleotide-binding domain-containing protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MGAEETLFQRFGKEFPQGTELFREGEAGKEMFVIQAGRVAISKRVRDVEKVLAVLGPGEFFGEMAIISNKPRNASATVNE
DARLLVIDPKTFEGMIRGNAEIAVRMIKKLAERLSEADAQIENLLHNDPASRVVHQIIQACQSRGRPLDEGVEIDFAMRE
LPRQIGVGEPAVRAVVDRLERSGLVERNGDRMTVPDTARLHDFLQYLEMKWKFGDL

Sequences:

>Translated_216_residues
MGAEETLFQRFGKEFPQGTELFREGEAGKEMFVIQAGRVAISKRVRDVEKVLAVLGPGEFFGEMAIISNKPRNASATVNE
DARLLVIDPKTFEGMIRGNAEIAVRMIKKLAERLSEADAQIENLLHNDPASRVVHQIIQACQSRGRPLDEGVEIDFAMRE
LPRQIGVGEPAVRAVVDRLERSGLVERNGDRMTVPDTARLHDFLQYLEMKWKFGDL
>Mature_215_residues
GAEETLFQRFGKEFPQGTELFREGEAGKEMFVIQAGRVAISKRVRDVEKVLAVLGPGEFFGEMAIISNKPRNASATVNED
ARLLVIDPKTFEGMIRGNAEIAVRMIKKLAERLSEADAQIENLLHNDPASRVVHQIIQACQSRGRPLDEGVEIDFAMREL
PRQIGVGEPAVRAVVDRLERSGLVERNGDRMTVPDTARLHDFLQYLEMKWKFGDL

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=187, Percent_Identity=24.0641711229947, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24246; Mature: 24115

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAEETLFQRFGKEFPQGTELFREGEAGKEMFVIQAGRVAISKRVRDVEKVLAVLGPGEF
CCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
FGEMAIISNKPRNASATVNEDARLLVIDPKTFEGMIRGNAEIAVRMIKKLAERLSEADAQ
HHHHHHHCCCCCCCCCEECCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IENLLHNDPASRVVHQIIQACQSRGRPLDEGVEIDFAMRELPRQIGVGEPAVRAVVDRLE
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RSGLVERNGDRMTVPDTARLHDFLQYLEMKWKFGDL
HCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GAEETLFQRFGKEFPQGTELFREGEAGKEMFVIQAGRVAISKRVRDVEKVLAVLGPGEF
CCHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
FGEMAIISNKPRNASATVNEDARLLVIDPKTFEGMIRGNAEIAVRMIKKLAERLSEADAQ
HHHHHHHCCCCCCCCCEECCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IENLLHNDPASRVVHQIIQACQSRGRPLDEGVEIDFAMRELPRQIGVGEPAVRAVVDRLE
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RSGLVERNGDRMTVPDTARLHDFLQYLEMKWKFGDL
HCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]