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The map label for this gene is mdtA [H]

Identifier: 108758724

GI number: 108758724

Start: 4696579

End: 4697766

Strand: Reverse

Name: mdtA [H]

Synonym: MXAN_3904

Alternate gene names: 108758724

Gene position: 4697766-4696579 (Counterclockwise)

Preceding gene: 108761364

Following gene: 108761482

Centisome position: 51.4

GC content: 74.07

Gene sequence:

>1188_bases
ATGCGACGCGCAGGAACGTTGGGTCTGGCCGTGGCCGCGCTGGCCCTGGCGGCTGGCTGCAAGAAGGACGCGCAAAGCGC
CCAAGGCGGAGCAGCGCCGGCAGGTCGCGGCCGAGCAGCCATCCAGTTCCCCGTCGAGGTGGCTCCGGTGGAGTCGCGGG
ACGTGGAGTACGTGGTGGACGCGGTGGGCTCCGTGGAGGCCTTCGAGCGGGTGCAGATCACCGCCCGCGTGCCGGGCGCC
GTGGAGCGGGTGCTCTTCGCGGAAGGGCAGTCGGTGAAGAGGGGCGCGGTGCTCGCGGAGATCGAGCCCGCCCGCTACGC
CATCGCCGTGCGGTCCGCGGAGGCCGCGCTGGCGCGAGCCCGCGCCACGCTGGTGGAGGCGGAGGCCGGTGCGCAGCGCC
GCACCGCGGTGAACCAGGCCAGCCCCGGTCTGCTGCCCGCCGAGCAGTTGGAGACCTTCGAGGCGCGCGCGCGCACGGCG
GAGGCGGACGTGGCGGCGGCGAAGGCGCTGCTGGACCAGGCGCAGCTCAACCAGCGTGACGCCTATGTGCGCGCGCCCAT
GGACGGCGTGCTCCAGACGCGCACGGTGCAGACGGGCCAGTACGTGCAGCCCGGCATCGTGTTGGCCACGCTGCTGCGGC
GCGAGCCGTTGCTGCTGCGCTTCACGGTTCCGGCGGCGGACGTGTCCCGCATCCAGCCCGGCATGACGGCGCGCTTCTCC
GTTCGGGCCGCGGAGGGTGGCTCTTTCACGGCGAAAATCACACACGTGGCCGCCGCCGCGGATGATGCCAGCCGCATGGT
GCCGGTGACGGCGGAAGTCACCGGTGAGGACGCCGAGCGGCTCCGTCCGGGCGCCTTCGCCACGGTGGCGGTGCCCGTGG
ATACGCGCGGCGGCAGTCCGGTGATTCCGCAGACGGCGGTGCGCGCCAGCGAACGCGGCTTCCTGGCCTACGTGGTGGAG
GGCAACAAGGCGCGTGAGCGCGTGCTGGAGCTGGGCCTGCGCACCGCGGATGGCCGCGTGGAGGTCCGTGACGGCGTGAA
GCCCGGTGAGCTGCTGGTGGTGCGCGGCGGTGAGGCCCTGCGCGACGGGGCCAACGTGCGCGTGGCGGAGGGACCCAAAC
CCACCTTCACGGGTGAGCCCCGGCTGGAGCCGGAGGCCGCCAGCGGCGGCGGAGGCGCCCGGCAATGA

Upstream 100 bases:

>100_bases
AGGTGGCGTATGCCCAGAGCCGGTTCGCGCTGGGCGTGGCGCTGCTGGGGCTGCGGGCGGCAGTCGGACTCGACCCATTG
GGGAAGGAACCGTGAAGGAC

Downstream 100 bases:

>100_bases
ACATCACCGAGGCGTGCATCAAGAAGCCCGTCCTGGCGTGGATGATCATGGCGGCCACCATCGTCTTCGGACTGGTGGCC
GCGCAGCGTATTGGCATCAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MRRAGTLGLAVAALALAAGCKKDAQSAQGGAAPAGRGRAAIQFPVEVAPVESRDVEYVVDAVGSVEAFERVQITARVPGA
VERVLFAEGQSVKRGAVLAEIEPARYAIAVRSAEAALARARATLVEAEAGAQRRTAVNQASPGLLPAEQLETFEARARTA
EADVAAAKALLDQAQLNQRDAYVRAPMDGVLQTRTVQTGQYVQPGIVLATLLRREPLLLRFTVPAADVSRIQPGMTARFS
VRAAEGGSFTAKITHVAAAADDASRMVPVTAEVTGEDAERLRPGAFATVAVPVDTRGGSPVIPQTAVRASERGFLAYVVE
GNKARERVLELGLRTADGRVEVRDGVKPGELLVVRGGEALRDGANVRVAEGPKPTFTGEPRLEPEAASGGGGARQ

Sequences:

>Translated_395_residues
MRRAGTLGLAVAALALAAGCKKDAQSAQGGAAPAGRGRAAIQFPVEVAPVESRDVEYVVDAVGSVEAFERVQITARVPGA
VERVLFAEGQSVKRGAVLAEIEPARYAIAVRSAEAALARARATLVEAEAGAQRRTAVNQASPGLLPAEQLETFEARARTA
EADVAAAKALLDQAQLNQRDAYVRAPMDGVLQTRTVQTGQYVQPGIVLATLLRREPLLLRFTVPAADVSRIQPGMTARFS
VRAAEGGSFTAKITHVAAAADDASRMVPVTAEVTGEDAERLRPGAFATVAVPVDTRGGSPVIPQTAVRASERGFLAYVVE
GNKARERVLELGLRTADGRVEVRDGVKPGELLVVRGGEALRDGANVRVAEGPKPTFTGEPRLEPEAASGGGGARQ
>Mature_395_residues
MRRAGTLGLAVAALALAAGCKKDAQSAQGGAAPAGRGRAAIQFPVEVAPVESRDVEYVVDAVGSVEAFERVQITARVPGA
VERVLFAEGQSVKRGAVLAEIEPARYAIAVRSAEAALARARATLVEAEAGAQRRTAVNQASPGLLPAEQLETFEARARTA
EADVAAAKALLDQAQLNQRDAYVRAPMDGVLQTRTVQTGQYVQPGIVLATLLRREPLLLRFTVPAADVSRIQPGMTARFS
VRAAEGGSFTAKITHVAAAADDASRMVPVTAEVTGEDAERLRPGAFATVAVPVDTRGGSPVIPQTAVRASERGFLAYVVE
GNKARERVLELGLRTADGRVEVRDGVKPGELLVVRGGEALRDGANVRVAEGPKPTFTGEPRLEPEAASGGGGARQ

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=394, Percent_Identity=27.1573604060914, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081951, Length=137, Percent_Identity=32.8467153284672, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789929, Length=316, Percent_Identity=23.4177215189873, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081796, Length=326, Percent_Identity=27.3006134969325, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41200; Mature: 41200

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAGTLGLAVAALALAAGCKKDAQSAQGGAAPAGRGRAAIQFPVEVAPVESRDVEYVVD
CCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEECEEEECCCCCCHHHHHH
AVGSVEAFERVQITARVPGAVERVLFAEGQSVKRGAVLAEIEPARYAIAVRSAEAALARA
HHCCHHHHHEEEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHH
RATLVEAEAGAQRRTAVNQASPGLLPAEQLETFEARARTAEADVAAAKALLDQAQLNQRD
HHHHHECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYVRAPMDGVLQTRTVQTGQYVQPGIVLATLLRREPLLLRFTVPAADVSRIQPGMTARFS
CEEECCCHHHHEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCEEEEE
VRAAEGGSFTAKITHVAAAADDASRMVPVTAEVTGEDAERLRPGAFATVAVPVDTRGGSP
EEECCCCCEEEEEEEEEECCCCCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEECCCCCC
VIPQTAVRASERGFLAYVVEGNKARERVLELGLRTADGRVEVRDGVKPGELLVVRGGEAL
CCCHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCHHH
RDGANVRVAEGPKPTFTGEPRLEPEAASGGGGARQ
HCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRAGTLGLAVAALALAAGCKKDAQSAQGGAAPAGRGRAAIQFPVEVAPVESRDVEYVVD
CCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEECEEEECCCCCCHHHHHH
AVGSVEAFERVQITARVPGAVERVLFAEGQSVKRGAVLAEIEPARYAIAVRSAEAALARA
HHCCHHHHHEEEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHH
RATLVEAEAGAQRRTAVNQASPGLLPAEQLETFEARARTAEADVAAAKALLDQAQLNQRD
HHHHHECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYVRAPMDGVLQTRTVQTGQYVQPGIVLATLLRREPLLLRFTVPAADVSRIQPGMTARFS
CEEECCCHHHHEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCEEEEE
VRAAEGGSFTAKITHVAAAADDASRMVPVTAEVTGEDAERLRPGAFATVAVPVDTRGGSP
EEECCCCCEEEEEEEEEECCCCCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEECCCCCC
VIPQTAVRASERGFLAYVVEGNKARERVLELGLRTADGRVEVRDGVKPGELLVVRGGEAL
CCCHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCHHH
RDGANVRVAEGPKPTFTGEPRLEPEAASGGGGARQ
HCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA