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The map label for this gene is ptrB [C]

Identifier: 108758082

GI number: 108758082

Start: 3665267

End: 3667474

Strand: Reverse

Name: ptrB [C]

Synonym: MXAN_3129

Alternate gene names: 108758082

Gene position: 3667474-3665267 (Counterclockwise)

Preceding gene: 108757859

Following gene: 108757078

Centisome position: 40.13

GC content: 67.93

Gene sequence:

>2208_bases
GTGAAGCTGAAGACCGCATTGACGGCGGCGGTGCTGACCCTGCCGCTGGCTGCGCCAGCCGCCCCCGCCCCCGCGCCGGC
CGCGACGGCGCCCCGCAAGGCTGCCTCCAAGGCGCCCGCGTCGCCGAAGAAGGAGACGGTGGACACCTACCACGGCACGG
CGGTGAAGGACCCGTACCAGTGGCTGGAGGACTCGTCCGACGCGCAGGTGAAGCAGTGGAACGACGCGCAGAACGCGTAC
ACCCGCGCCCTCCTGGACAAGCTGTCCGGACGCGATGCCATCCGCCAGCGCGTCTCCGAGCTGCTGAGCTGGAAGTCCCC
TGGCTACGGCGGGCTGCACGAGGCCGGCGGCACGTTGTTCGCCATGAAGGCCCAGCCGCCCAAGCAGCAGTCCTTCCTGG
TCGTGCTCGACTCGGTGGATGACACGTCCAAGGAGCGCGTGCTGGTGGACCCCATGGTGGTGGACGCCTCGGGCCACACC
ACCATCGACTGGTACGTCCCCACGCTGGACGGCAAGAAGATCGCCGTGTCGATGTCGAAGAACGGCACCGAGAGCGGCGA
CGTCACCGTCTATGACGTGGCCACCGGCAAGCCGCTGCCGAATGAGACCGTGCCCCGCGTGAATGGTGGCACCGCGGGTG
GCAGCCTGACGTGGACGGCGGACGGCAAGGGCTACTTCTACACGCGCTACCCGCGCGGCGAGGAGCGCCCCGAGGCGGAC
CGTGACTTCTTCCAGCAGGTCTACTTCCACCAGCTCGGCACGCCCACGGAGAAGGACACGTATGTGCTGGGCAAGGACTT
CCCGCGCATCGCGATGACGGAGCTGGACACGTCTCACGACGGCCAGCACATCTCCGCCGTCGTGGCCAACGGCGACGGCG
GCGAGTACATGCTGTACCTGCGCGACGCCGCCGGGAAGTGGTCGCAGGTATCGAAGTTCGAGGACAAAGTCATCCGCGCG
CGCTTCGGCCACGACGGCGCCATGTACCTGCTCAGCCGCAAGGACGCGCCGCGCGGCAAGGTGCTGCGGCTGCCGCTGGC
CACGCCCACGCTGGACAAGGCCACGGTGGTGGTGCCGGAGGGCGAGGCCAGCATCCAGGGCTTCTTCCCCACGAAGTCGC
GGCTCTACGTGAGCGAGCAGCTCGGCGGGCCTTCGCAGTTGCGCATGGTGGACCTGAAGGGCAAGGCGCTGGGGATGGTG
CCCACCCTGCCCGTGTCTTCCGTGGGCGGGCTCGTGAGCCAGGGCGATGACGACGTGCTCTTCATCAACACCAGCTTCAC
CCAGCCGATGGCCTGGTACCGGTACTCGGCGAAGGACAACTCGGTGAAGAAGACGGCGCTGGCCCGCACGTCGCCGCTGG
ACCTGAGCGACGTGGAGGTGGTGCGCGCGTTCGCCACGTCCAAGGACGGCACCAAGGTCCCCGTCAGCATCCTCAAGAAG
AAGGGCACCAGGCTCAACGGCAACAACCCGGCGCTGCTGACGGGCTACGGCGGCTTCAACATCTCCATCAGCCCGAACTA
CAACACGCTGGCCGGTTTCTGGCTGGAACAGGGCGGCGTGTTCGCGGTAGCCAACCTGCGCGGCGGCTCGGAGTTCGGCG
AGAAGTGGCACGCCGAGGGCTCGCTCACGAACAAGCAGAACGTCTTCGACGACTTCCACGCCGCCGCGAAGCTGCTGGTG
GACCAGAAGTACACGCAGCCGAAGAAGCTGGCCATCCAGGGTGGCAGCAACGGCGGCCTCCTGATGGGCGCGGCCGTCAC
CCAGCACCCGGAGATGTACGGCGCCGTCGTGGCGCGCGTGGGCATCTACGACATGCTCCGGGTGGAGCTGACGCCCAACG
GCCAGTTCAACATCACCGAGTACGGCACCGTGAAGAACCCGGAGCAGTTCAAGGCGCTGCACGCGTACTCGCCGCTCCAC
AACGTCAAGGACGGCACGGCCTACCCCTCCGTGCTCTTCACGTCCGGCGCGAACGACCCGCGCGTGGACCCGTTCCACTC
GCGGAAGATGGTGGCCCGGATGCAGGAGGCCACCAAGGCGAAGAACCCCATCCTGCTGCGCGCCAACGCGGAGACGGGCC
ACGGCGCCGGCACGCCGCTGAACGCGCGCATCGAGGAGGAAGTGGACGTGTACTCGTTCGTGTTCAACGCCCTGGGCATG
AAGTACCAGCCCCCGGCGAAGAAGGTCGCGGCGCCCAAGCCGCAGTAG

Upstream 100 bases:

>100_bases
AACACCCGGCGCACGGCGGCATTCCCGACGCAACGAAGCCGTTTCCCGTCCCAAGGGACGTGGCAGGCTGCGTGCGCGTT
TCCCAACCCCGAGGTGAACC

Downstream 100 bases:

>100_bases
CCGCGTGAGGCCTGCATCCACCGCCGCCCGGACGCTGGCGCGGCGGTGGATGCGGTGCTGCACCGCGAATCAGCAGGTCC
AGGTACAGGCCGTGCCGCCC

Product: S9A family peptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MKLKTALTAAVLTLPLAAPAAPAPAPAATAPRKAASKAPASPKKETVDTYHGTAVKDPYQWLEDSSDAQVKQWNDAQNAY
TRALLDKLSGRDAIRQRVSELLSWKSPGYGGLHEAGGTLFAMKAQPPKQQSFLVVLDSVDDTSKERVLVDPMVVDASGHT
TIDWYVPTLDGKKIAVSMSKNGTESGDVTVYDVATGKPLPNETVPRVNGGTAGGSLTWTADGKGYFYTRYPRGEERPEAD
RDFFQQVYFHQLGTPTEKDTYVLGKDFPRIAMTELDTSHDGQHISAVVANGDGGEYMLYLRDAAGKWSQVSKFEDKVIRA
RFGHDGAMYLLSRKDAPRGKVLRLPLATPTLDKATVVVPEGEASIQGFFPTKSRLYVSEQLGGPSQLRMVDLKGKALGMV
PTLPVSSVGGLVSQGDDDVLFINTSFTQPMAWYRYSAKDNSVKKTALARTSPLDLSDVEVVRAFATSKDGTKVPVSILKK
KGTRLNGNNPALLTGYGGFNISISPNYNTLAGFWLEQGGVFAVANLRGGSEFGEKWHAEGSLTNKQNVFDDFHAAAKLLV
DQKYTQPKKLAIQGGSNGGLLMGAAVTQHPEMYGAVVARVGIYDMLRVELTPNGQFNITEYGTVKNPEQFKALHAYSPLH
NVKDGTAYPSVLFTSGANDPRVDPFHSRKMVARMQEATKAKNPILLRANAETGHGAGTPLNARIEEEVDVYSFVFNALGM
KYQPPAKKVAAPKPQ

Sequences:

>Translated_735_residues
MKLKTALTAAVLTLPLAAPAAPAPAPAATAPRKAASKAPASPKKETVDTYHGTAVKDPYQWLEDSSDAQVKQWNDAQNAY
TRALLDKLSGRDAIRQRVSELLSWKSPGYGGLHEAGGTLFAMKAQPPKQQSFLVVLDSVDDTSKERVLVDPMVVDASGHT
TIDWYVPTLDGKKIAVSMSKNGTESGDVTVYDVATGKPLPNETVPRVNGGTAGGSLTWTADGKGYFYTRYPRGEERPEAD
RDFFQQVYFHQLGTPTEKDTYVLGKDFPRIAMTELDTSHDGQHISAVVANGDGGEYMLYLRDAAGKWSQVSKFEDKVIRA
RFGHDGAMYLLSRKDAPRGKVLRLPLATPTLDKATVVVPEGEASIQGFFPTKSRLYVSEQLGGPSQLRMVDLKGKALGMV
PTLPVSSVGGLVSQGDDDVLFINTSFTQPMAWYRYSAKDNSVKKTALARTSPLDLSDVEVVRAFATSKDGTKVPVSILKK
KGTRLNGNNPALLTGYGGFNISISPNYNTLAGFWLEQGGVFAVANLRGGSEFGEKWHAEGSLTNKQNVFDDFHAAAKLLV
DQKYTQPKKLAIQGGSNGGLLMGAAVTQHPEMYGAVVARVGIYDMLRVELTPNGQFNITEYGTVKNPEQFKALHAYSPLH
NVKDGTAYPSVLFTSGANDPRVDPFHSRKMVARMQEATKAKNPILLRANAETGHGAGTPLNARIEEEVDVYSFVFNALGM
KYQPPAKKVAAPKPQ
>Mature_735_residues
MKLKTALTAAVLTLPLAAPAAPAPAPAATAPRKAASKAPASPKKETVDTYHGTAVKDPYQWLEDSSDAQVKQWNDAQNAY
TRALLDKLSGRDAIRQRVSELLSWKSPGYGGLHEAGGTLFAMKAQPPKQQSFLVVLDSVDDTSKERVLVDPMVVDASGHT
TIDWYVPTLDGKKIAVSMSKNGTESGDVTVYDVATGKPLPNETVPRVNGGTAGGSLTWTADGKGYFYTRYPRGEERPEAD
RDFFQQVYFHQLGTPTEKDTYVLGKDFPRIAMTELDTSHDGQHISAVVANGDGGEYMLYLRDAAGKWSQVSKFEDKVIRA
RFGHDGAMYLLSRKDAPRGKVLRLPLATPTLDKATVVVPEGEASIQGFFPTKSRLYVSEQLGGPSQLRMVDLKGKALGMV
PTLPVSSVGGLVSQGDDDVLFINTSFTQPMAWYRYSAKDNSVKKTALARTSPLDLSDVEVVRAFATSKDGTKVPVSILKK
KGTRLNGNNPALLTGYGGFNISISPNYNTLAGFWLEQGGVFAVANLRGGSEFGEKWHAEGSLTNKQNVFDDFHAAAKLLV
DQKYTQPKKLAIQGGSNGGLLMGAAVTQHPEMYGAVVARVGIYDMLRVELTPNGQFNITEYGTVKNPEQFKALHAYSPLH
NVKDGTAYPSVLFTSGANDPRVDPFHSRKMVARMQEATKAKNPILLRANAETGHGAGTPLNARIEEEVDVYSFVFNALGM
KYQPPAKKVAAPKPQ

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=719, Percent_Identity=34.2141863699583, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI108860686, Length=332, Percent_Identity=26.2048192771084, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI284172438, Length=244, Percent_Identity=29.9180327868852, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI284172431, Length=244, Percent_Identity=29.9180327868852, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI284172420, Length=207, Percent_Identity=31.8840579710145, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI284172413, Length=207, Percent_Identity=31.8840579710145, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI70778815, Length=207, Percent_Identity=31.8840579710145, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI108860692, Length=232, Percent_Identity=30.6034482758621, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1788150, Length=237, Percent_Identity=32.9113924050633, Blast_Score=152, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24583414, Length=716, Percent_Identity=33.5195530726257, Blast_Score=368, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221510989, Length=705, Percent_Identity=31.2056737588652, Blast_Score=318, Evalue=9e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 79578; Mature: 79578

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKTALTAAVLTLPLAAPAAPAPAPAATAPRKAASKAPASPKKETVDTYHGTAVKDPYQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCCHHH
WLEDSSDAQVKQWNDAQNAYTRALLDKLSGRDAIRQRVSELLSWKSPGYGGLHEAGGTLF
HHCCCCCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
AMKAQPPKQQSFLVVLDSVDDTSKERVLVDPMVVDASGHTTIDWYVPTLDGKKIAVSMSK
EEECCCCCCCEEEEEEECCCCCCCCEEEECEEEEECCCCEEEEEEEECCCCCEEEEEECC
NGTESGDVTVYDVATGKPLPNETVPRVNGGTAGGSLTWTADGKGYFYTRYPRGEERPEAD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCHH
RDFFQQVYFHQLGTPTEKDTYVLGKDFPRIAMTELDTSHDGQHISAVVANGDGGEYMLYL
HHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEEEE
RDAAGKWSQVSKFEDKVIRARFGHDGAMYLLSRKDAPRGKVLRLPLATPTLDKATVVVPE
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEC
GEASIQGFFPTKSRLYVSEQLGGPSQLRMVDLKGKALGMVPTLPVSSVGGLVSQGDDDVL
CCCCEEEECCCCCEEEEEHHCCCCCCEEEEEECCCEECCCCCCCHHHHCCHHHCCCCCEE
FINTSFTQPMAWYRYSAKDNSVKKTALARTSPLDLSDVEVVRAFATSKDGTKVPVSILKK
EEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
KGTRLNGNNPALLTGYGGFNISISPNYNTLAGFWLEQGGVFAVANLRGGSEFGEKWHAEG
CCCEECCCCCEEEEECCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHCCCC
SLTNKQNVFDDFHAAAKLLVDQKYTQPKKLAIQGGSNGGLLMGAAVTQHPEMYGAVVARV
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECHHHCCCHHHHHHHHHH
GIYDMLRVELTPNGQFNITEYGTVKNPEQFKALHAYSPLHNVKDGTAYPSVLFTSGANDP
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCHHCCCCCCCCCCEEEECCCCCC
RVDPFHSRKMVARMQEATKAKNPILLRANAETGHGAGTPLNARIEEEVDVYSFVFNALGM
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
KYQPPAKKVAAPKPQ
CCCCCHHHCCCCCCC
>Mature Secondary Structure
MKLKTALTAAVLTLPLAAPAAPAPAPAATAPRKAASKAPASPKKETVDTYHGTAVKDPYQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCCHHH
WLEDSSDAQVKQWNDAQNAYTRALLDKLSGRDAIRQRVSELLSWKSPGYGGLHEAGGTLF
HHCCCCCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
AMKAQPPKQQSFLVVLDSVDDTSKERVLVDPMVVDASGHTTIDWYVPTLDGKKIAVSMSK
EEECCCCCCCEEEEEEECCCCCCCCEEEECEEEEECCCCEEEEEEEECCCCCEEEEEECC
NGTESGDVTVYDVATGKPLPNETVPRVNGGTAGGSLTWTADGKGYFYTRYPRGEERPEAD
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCHH
RDFFQQVYFHQLGTPTEKDTYVLGKDFPRIAMTELDTSHDGQHISAVVANGDGGEYMLYL
HHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCCEEEEEEEECCCCEEEEEE
RDAAGKWSQVSKFEDKVIRARFGHDGAMYLLSRKDAPRGKVLRLPLATPTLDKATVVVPE
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEC
GEASIQGFFPTKSRLYVSEQLGGPSQLRMVDLKGKALGMVPTLPVSSVGGLVSQGDDDVL
CCCCEEEECCCCCEEEEEHHCCCCCCEEEEEECCCEECCCCCCCHHHHCCHHHCCCCCEE
FINTSFTQPMAWYRYSAKDNSVKKTALARTSPLDLSDVEVVRAFATSKDGTKVPVSILKK
EEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
KGTRLNGNNPALLTGYGGFNISISPNYNTLAGFWLEQGGVFAVANLRGGSEFGEKWHAEG
CCCEECCCCCEEEEECCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHCCCC
SLTNKQNVFDDFHAAAKLLVDQKYTQPKKLAIQGGSNGGLLMGAAVTQHPEMYGAVVARV
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECHHHCCCHHHHHHHHHH
GIYDMLRVELTPNGQFNITEYGTVKNPEQFKALHAYSPLHNVKDGTAYPSVLFTSGANDP
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCHHCCCCCCCCCCEEEECCCCCC
RVDPFHSRKMVARMQEATKAKNPILLRANAETGHGAGTPLNARIEEEVDVYSFVFNALGM
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
KYQPPAKKVAAPKPQ
CCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]