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The map label for this gene is bioA [H]

Identifier: 108757979

GI number: 108757979

Start: 374231

End: 375562

Strand: Direct

Name: bioA [H]

Synonym: MXAN_0318

Alternate gene names: 108757979

Gene position: 374231-375562 (Clockwise)

Preceding gene: 108760711

Following gene: 108761610

Centisome position: 4.09

GC content: 69.89

Gene sequence:

>1332_bases
GTGAAGCGGGCGGACATCGTCGGATTGGACAAGGCGCACGTCTGGCATCCCTACACGGCGATGGAGGCCTACATCGCGGA
GACGGATCCGCTGGTGGTGGTGCGCTCGGAAGGGGCGTACCTCCATGACGCGGACGGCACGCGCTATCTGGACGCCAACG
GCTCCTGGTGGGTGTCCACGCTGGGCCACCGTCACCCGCGCTTGATGCGCGCGCTCGCCGAGCAGGCCGCCGCACTCCCA
CACGTCTCCCTGGCGGGCATCACCCACGAGCCGGCGGCCTTGCTGGCGTCGGAGCTGGCGGCCATCGCCCCCGGCTCGGA
CCGCCCCGGCCTTCCCTCATCCGAGCGGCTGTCCCGCGTCTTCTATTCCGACAACGGCAGCACGGCGGTGGAGGTGGCCA
TCAAGATGGCGGCCCAGTACTGGGCGCAGAATGGCCAGCCGCGCCGCACCCGCTTCATCACGCTGTCGGGGGCATTCCAC
GGCGAGACGATGGGCGCCACCAGCGTGGGGGGCGTTCCCCTGTTCCGGGAGGTCTTCGGCCCGCTGCTCTTCGACGTGGT
GCACGTCCCCTCTCCAGCGGAGGAGGGGGGCTGGGCGCGCGCCTTCGAGCAAGTCCAGTCCACCCTGCGGGCGCACCCGG
AGGTGATTGCGGGCGTCATTTTGGAGCCGGTGCTGCAGGGCGCGGCGGGCATGGTGATGTACTCGCCAGACTTCGTCCGG
GCGGTACGTGAGGCCACGAGCGAGGTGGATACCTTCCTCATCGCCGACGAGGTCTTCACGGGGCTGGGGCGCACGGGCGC
ACGCTTCGCGGTGGACCTGGCGGGCGTGGTGCCGGACATGCTGTGTCTGGCGAAGGCCCTCTCGGGAGGAATCCTGCCGT
TTGGCGCCACCCTGGCCTCGGAGCGCGTCTTCTCCGGCTTCCTCGGGGCGTCGAACCGGGCGCTGTATTACGGGCACTCG
TACTGTGGGAACCCGTTGGGCGCCGCCATCGCCCGGGAAGTGCTGGCCGTCTACCGGGACGAGGATGTGATGGGGCAGGT
GGCTCGAAAGGCCCCCCGCGTGAAAGCCGCCTTCGAGCGGATGGCCGCCTCGATTCCGGGCCTGGTTCGCCCCCGCGCCG
TGGGAATGGTAGGCGCGGTGGACCTGGGCGGTGGTGGTTACCTCGCTCGGGGAGGGTGGCGAGTGTACGAGGCCGCGCGT
CGCCGAGGGCTCTACCTGCGGCCCATGGGAGACACCGTGTACATCGCGCCGGCACTGACTATCTCTGACGAGGCGCTCGA
GGAGCTGCTGTCCGGAGTGGAAGCGTCACTCCAAGAAGTCGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
GGCCATCAGTAGAACGCGCCGTGGCATGACATGACGCGCGGCGGCGCGGCCCACTCTTCCGGTACGGAGGGGTACGGAGC
TCCAGGAGAGGAGTACACGC

Downstream 100 bases:

>100_bases
GCCTGATGGATCCGCTGCCTACGAATGTGTGGGAGCGAACGGAACGGTGGTTGACAGGTCGCGCGTCGCAGGGATAGAAG
CCGCGCCCCGCCCGACGCAG

Product: putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKRADIVGLDKAHVWHPYTAMEAYIAETDPLVVVRSEGAYLHDADGTRYLDANGSWWVSTLGHRHPRLMRALAEQAAALP
HVSLAGITHEPAALLASELAAIAPGSDRPGLPSSERLSRVFYSDNGSTAVEVAIKMAAQYWAQNGQPRRTRFITLSGAFH
GETMGATSVGGVPLFREVFGPLLFDVVHVPSPAEEGGWARAFEQVQSTLRAHPEVIAGVILEPVLQGAAGMVMYSPDFVR
AVREATSEVDTFLIADEVFTGLGRTGARFAVDLAGVVPDMLCLAKALSGGILPFGATLASERVFSGFLGASNRALYYGHS
YCGNPLGAAIAREVLAVYRDEDVMGQVARKAPRVKAAFERMAASIPGLVRPRAVGMVGAVDLGGGGYLARGGWRVYEAAR
RRGLYLRPMGDTVYIAPALTISDEALEELLSGVEASLQEVAGG

Sequences:

>Translated_443_residues
MKRADIVGLDKAHVWHPYTAMEAYIAETDPLVVVRSEGAYLHDADGTRYLDANGSWWVSTLGHRHPRLMRALAEQAAALP
HVSLAGITHEPAALLASELAAIAPGSDRPGLPSSERLSRVFYSDNGSTAVEVAIKMAAQYWAQNGQPRRTRFITLSGAFH
GETMGATSVGGVPLFREVFGPLLFDVVHVPSPAEEGGWARAFEQVQSTLRAHPEVIAGVILEPVLQGAAGMVMYSPDFVR
AVREATSEVDTFLIADEVFTGLGRTGARFAVDLAGVVPDMLCLAKALSGGILPFGATLASERVFSGFLGASNRALYYGHS
YCGNPLGAAIAREVLAVYRDEDVMGQVARKAPRVKAAFERMAASIPGLVRPRAVGMVGAVDLGGGGYLARGGWRVYEAAR
RRGLYLRPMGDTVYIAPALTISDEALEELLSGVEASLQEVAGG
>Mature_443_residues
MKRADIVGLDKAHVWHPYTAMEAYIAETDPLVVVRSEGAYLHDADGTRYLDANGSWWVSTLGHRHPRLMRALAEQAAALP
HVSLAGITHEPAALLASELAAIAPGSDRPGLPSSERLSRVFYSDNGSTAVEVAIKMAAQYWAQNGQPRRTRFITLSGAFH
GETMGATSVGGVPLFREVFGPLLFDVVHVPSPAEEGGWARAFEQVQSTLRAHPEVIAGVILEPVLQGAAGMVMYSPDFVR
AVREATSEVDTFLIADEVFTGLGRTGARFAVDLAGVVPDMLCLAKALSGGILPFGATLASERVFSGFLGASNRALYYGHS
YCGNPLGAAIAREVLAVYRDEDVMGQVARKAPRVKAAFERMAASIPGLVRPRAVGMVGAVDLGGGGYLARGGWRVYEAAR
RRGLYLRPMGDTVYIAPALTISDEALEELLSGVEASLQEVAGG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.3148148148148, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=28.75, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI37574042, Length=445, Percent_Identity=23.3707865168539, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=22.4719101123595, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=22.4806201550388, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=34.4519015659955, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI145693181, Length=400, Percent_Identity=33, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=29.126213592233, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=31.6176470588235, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=28.1030444964871, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=28.4009546539379, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786349, Length=306, Percent_Identity=29.0849673202614, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=452, Percent_Identity=26.3274336283186, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=24.6268656716418, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=271, Percent_Identity=26.5682656826568, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=471, Percent_Identity=28.6624203821656, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=29.4964028776978, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=29.4252873563218, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21357415, Length=431, Percent_Identity=26.4501160092807, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356575, Length=356, Percent_Identity=28.9325842696629, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28574759, Length=368, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI161085790, Length=371, Percent_Identity=26.6846361185984, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47143; Mature: 47143

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRADIVGLDKAHVWHPYTAMEAYIAETDPLVVVRSEGAYLHDADGTRYLDANGSWWVST
CCCCCEECCCCCCEECCHHHHHHHHCCCCCEEEEECCCCEEECCCCCEEEECCCCEEHHH
LGHRHPRLMRALAEQAAALPHVSLAGITHEPAALLASELAAIAPGSDRPGLPSSERLSRV
HCCCCHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FYSDNGSTAVEVAIKMAAQYWAQNGQPRRTRFITLSGAFHGETMGATSVGGVPLFREVFG
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
PLLFDVVHVPSPAEEGGWARAFEQVQSTLRAHPEVIAGVILEPVLQGAAGMVMYSPDFVR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEECHHHHH
AVREATSEVDTFLIADEVFTGLGRTGARFAVDLAGVVPDMLCLAKALSGGILPFGATLAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ERVFSGFLGASNRALYYGHSYCGNPLGAAIAREVLAVYRDEDVMGQVARKAPRVKAAFER
HHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHH
MAASIPGLVRPRAVGMVGAVDLGGGGYLARGGWRVYEAARRRGLYLRPMGDTVYIAPALT
HHHHCCCCCCCHHHCEEEEEEECCCCEEECCCHHHHHHHHHCCCEEEECCCEEEEEEEEE
ISDEALEELLSGVEASLQEVAGG
ECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRADIVGLDKAHVWHPYTAMEAYIAETDPLVVVRSEGAYLHDADGTRYLDANGSWWVST
CCCCCEECCCCCCEECCHHHHHHHHCCCCCEEEEECCCCEEECCCCCEEEECCCCEEHHH
LGHRHPRLMRALAEQAAALPHVSLAGITHEPAALLASELAAIAPGSDRPGLPSSERLSRV
HCCCCHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
FYSDNGSTAVEVAIKMAAQYWAQNGQPRRTRFITLSGAFHGETMGATSVGGVPLFREVFG
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
PLLFDVVHVPSPAEEGGWARAFEQVQSTLRAHPEVIAGVILEPVLQGAAGMVMYSPDFVR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEECHHHHH
AVREATSEVDTFLIADEVFTGLGRTGARFAVDLAGVVPDMLCLAKALSGGILPFGATLAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ERVFSGFLGASNRALYYGHSYCGNPLGAAIAREVLAVYRDEDVMGQVARKAPRVKAAFER
HHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHH
MAASIPGLVRPRAVGMVGAVDLGGGGYLARGGWRVYEAARRRGLYLRPMGDTVYIAPALT
HHHHCCCCCCCHHHCEEEEEEECCCCEEECCCHHHHHHHHHCCCEEEECCCEEEEEEEEE
ISDEALEELLSGVEASLQEVAGG
ECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]