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The map label for this gene is zraS [H]

Identifier: 108757961

GI number: 108757961

Start: 1074566

End: 1076044

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_0938

Alternate gene names: 108757961

Gene position: 1076044-1074566 (Counterclockwise)

Preceding gene: 108762471

Following gene: 108763352

Centisome position: 11.77

GC content: 70.05

Gene sequence:

>1479_bases
GTGAGACTCGCCCGCAAGTTCACCCTCGCCCTCGTCCTGCTCGCCATCGCCGTCATGGCGGGCTTGCAGTACGTCCAGGT
CCGCCGTGAGCTCGAGCGCTCCGCCCTGGACATGCAGCATGACCACCGGTTGCTCGGCCACACGCTCGCTGGCTCCATCG
GCAAGGCGTGGCAGCTCGCCGGGGAGCGCGAGGCGCTCACCCTGCTCCACCAGGCCAACCGCTTCCAGGAGCAGGTCCAC
CTGCGCTGGGTGTGGCTCGATGGCGGCCCCGGCACCCCGGCCCTCACCGGCTTCCCGCCGCGACTGCTCTCGACCCTGCT
CCAAGGCAAGGACGGCTCCATGGTGGACCCCGCCGTGGACCCCGGCCTGCTTCATTCGTACACGCCGGTGCTCATCGGCA
ACCGGCTGGGCGCCATCGAAATCACCGAGTCGCTGGGCGAACAGCAGAAGTACGTCAACACCGTGGTCATGGGCACCTTC
GCCGCCACCGCCGCCATGGCCATCGGCTTCATCGTGGCCGCCATGGCCATGGGCCGCCGGCTGGTGGGCGAGCCGGTGGA
CCAGCTCGTGTCCCTGGCCCACCGCATCGGCGAGGGCGACCTCACCGCCCGTGTGCCGCTCCCGCAGCGCCGCGGCGACG
AGCTCACCACGCTGGCCGGCGCCATGAACCGCATGGGCGAGCAACTGGAGGAGACGCGCTCGCGCCTCGCCACGGAGACG
GCCGCGCGCCTGTCCGCCGTGGACCACCTGCGTCACGCGGACCGGCTCACCACCGTGGGCAAGCTGGCCTCCGGCGTGGC
GCATGAGCTGGGCACCCCGCTCAACGTCGTCATGGGCCGGGCGAAGATGATCTCCTCCGGCGAGGCGGAGGGCGAGGAAG
TGGGCGAGTGCGCGCAAATCATCTCGCAGCAGGCCCAGCACATGACGGCCATCATCCGTCAGCTCCTCGACTTCGCGCGG
CGGAGGAAGCCGCACCGCGCGCCGGAAGACGTGCAGGGCCTGGTCGAACGCACCCTGTCGCTGCTGCGCTCCATGGCGGC
GCGAAACAGCGTCACGCTGGAGACGGACATCCCCGCGGGACTCACGGTGGAGGTGGACGCGGGCCAGGTGCAGCAGGTGC
TCACCAACCTGGTGATGAACGGTGTGCAGGCCATGAAGCAGCCGGGCACGGTGCGCGTGCGCGCGGCCCACACCCGGAGC
ACCCCGCCCCCGGACGTGGGCGGACCCGAGGCGGACTTCGTGCGCCTGGACGTGGAGGACGAGGGCCAGGGAATTCCCGA
GGACGTGCTGGCCCATCTCTTCGAGCCCTTCTTCACCACCAAGGACGTGGGAGAGGGCACCGGACTGGGCCTGTCTGTTT
CCTATGGGCTCATGTTGGAGCATGACGGCTGGATTGCCGTGCGCAGCGAGCCCGGACGCGGTAGCTGCTTCTCCATCTAC
CTGCCAAGGGGTGAAGACACATGCCAGGCCGCGTCCTAG

Upstream 100 bases:

>100_bases
TGTTGCAGCACTCGCGGTACGTTGTGAGAACCCACCTCCGGTCCGTGCGCTCCCTCCCCCTCGAGGCGCACGGACCGGAG
CAGCCTCTTTCGAACCGCCC

Downstream 100 bases:

>100_bases
TCGTCGAGGACGAGCGCGAGATGCGCGCGATGTTGGAGAAGGGGCTCACGCGCCGGGGCTTCACGCCCGTGGCGCTCCCG
TCTGCGGACGAGGCCCTGGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLAGEREALTLLHQANRFQEQVH
LRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVDPGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTF
AATAAMAIGFIVAAMAMGRRLVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATET
AARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQIISQQAQHMTAIIRQLLDFAR
RRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAGLTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRS
TPPPDVGGPEADFVRLDVEDEGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIY
LPRGEDTCQAAS

Sequences:

>Translated_492_residues
MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLAGEREALTLLHQANRFQEQVH
LRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVDPGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTF
AATAAMAIGFIVAAMAMGRRLVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATET
AARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQIISQQAQHMTAIIRQLLDFAR
RRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAGLTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRS
TPPPDVGGPEADFVRLDVEDEGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIY
LPRGEDTCQAAS
>Mature_492_residues
MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLAGEREALTLLHQANRFQEQVH
LRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVDPGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTF
AATAAMAIGFIVAAMAMGRRLVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATET
AARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQIISQQAQHMTAIIRQLLDFAR
RRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAGLTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRS
TPPPDVGGPEADFVRLDVEDEGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIY
LPRGEDTCQAAS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=29.4354838709677, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790300, Length=245, Percent_Identity=32.2448979591837, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=30.8641975308642, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=28.3842794759825, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788393, Length=505, Percent_Identity=22.7722772277228, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=326, Percent_Identity=25.1533742331288, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789149, Length=355, Percent_Identity=24.7887323943662, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786912, Length=291, Percent_Identity=27.1477663230241, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=23.7354085603113, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=364, Percent_Identity=23.6263736263736, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=26.8085106382979, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787894, Length=337, Percent_Identity=23.7388724035608, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=362, Percent_Identity=21.5469613259669, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=24.6913580246914, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53164; Mature: 53164

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEREALTLLHQANRFQEQVHLRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVD
CCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
PGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTFAATAAMAIGFIVAAMAMGRR
CCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATET
HHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
ISQQAQHMTAIIRQLLDFARRRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
LTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRSTPPPDVGGPEADFVRLDVED
CEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECC
EGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIY
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCEEEEE
LPRGEDTCQAAS
ECCCCCCCCCCC
>Mature Secondary Structure
MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEREALTLLHQANRFQEQVHLRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVD
CCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
PGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTFAATAAMAIGFIVAAMAMGRR
CCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATET
HHCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
ISQQAQHMTAIIRQLLDFARRRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
LTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRSTPPPDVGGPEADFVRLDVED
CEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECC
EGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIY
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCEEEEE
LPRGEDTCQAAS
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]