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The map label for this gene is moaA [H]

Identifier: 108757868

GI number: 108757868

Start: 5192795

End: 5193799

Strand: Direct

Name: moaA [H]

Synonym: MXAN_4233

Alternate gene names: 108757868

Gene position: 5192795-5193799 (Clockwise)

Preceding gene: 108757216

Following gene: 108761293

Centisome position: 56.82

GC content: 71.44

Gene sequence:

>1005_bases
GTGACGACACCTGCCCTCCAGCCCCCGCCTTCCGCGTTGGCTCCGCCCCTGCTGGACGCGCAGGGGCGGCGGATGACGTA
CCTGAGGCTGAGCATCACCGACCGGTGCAACTTCCGGTGCAGCTACTGCTCGCCCGCTTCGTGGGGTGGCAAGCGGGACC
TGCTGGGCCCCGAGGAGTTGGAGCGAATCACCTCCGTCTTCGCCCGCATGGGAATCCGCCGCGTGCGGCTCACCGGCGGC
GAGCCGTTGATCCGCCCGGACATCCTCGACATCGCCCGGCGCATCGCCGCGGTGCCCGGCATCCAGCACCTGGCCATCAC
CAGCAATGCCAGCCACCTGGAGCGGCTCGCCCGCCCCCTGCGCGAGGCGGGCGTCACCCAGCTCAACCTGAGCCTGGACA
CCCTCCTGGCGGAGACGTTCCGCCGCATCTCCAAACAGGGGGATTTCGACGCGGTGCTGCGAGGCGTGGACGCGGCGGCG
GGCGCCGGCTACGCGTCTCTCAAGCTCAACGTCGTCGTCATGCGGGGCGTGAACGACGAGGAAGCCTCCGCCCTGATCGC
CTATGCGCACGCGCGCGGCTTCACGCCCCGCTTCATCGAGCTGATGCCCTTCGGTCAGGGCACGCCGGTGCCCACCGCGG
AGCTGGTAGAGCGGCTCCAGGCGTCAGGACTGCCGCTGGAACCCGAGCCTGATGACACGGGCGACGCCGCCGGACCGGCG
CGCTACTGGCGTGCGCCCGGAGGCCGCGTGGGCTTCATCTCCCCGCTCACACAGAACTTCTGCGGCACCTGCAACCGCGT
GCGCGTGGCGTCCAATGGCGACTTGCGCAGCTGCCTCGGCGGCCGGGCGCAGGCGCCGCTGCACCAGCTCATCCGCGGCG
GCGCCAGCGACGTGGAGCTGGCCGTGGCCATCCGCCGGGCGCTGGGCGACAAGCCAGAAGGGCACCGCTTCACCGAGCCC
GGCAACGGCGCCACGTTGCTGTCCATGATGGGCATCGGCGGTTGA

Upstream 100 bases:

>100_bases
CCAAGTCCGCCGTCGTTCGTTCGGTGGCTGGCAACAAGGGGTGAGCCTGGCTGGAAGAGATGACCGCACGGGGGGCGGCT
GTTATGAGGACAGGTCCGCC

Downstream 100 bases:

>100_bases
AAACACGACGGGCGGGCCCGCGCCTTCGCGCCTGGCCCGCCCGAGTGTTCCAGGACCGTTTCCGCCGGCCCCGCGTGGCG
CGCTACTTCACCAGTCGAAT

Product: molybdenum cofactor biosynthesis protein MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEELERITSVFARMGIRRVRLTGG
EPLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPLREAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAA
GAGYASLKLNVVVMRGVNDEEASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPA
RYWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVELAVAIRRALGDKPEGHRFTEP
GNGATLLSMMGIGG

Sequences:

>Translated_334_residues
MTTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEELERITSVFARMGIRRVRLTGG
EPLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPLREAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAA
GAGYASLKLNVVVMRGVNDEEASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPA
RYWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVELAVAIRRALGDKPEGHRFTEP
GNGATLLSMMGIGG
>Mature_333_residues
TTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEELERITSVFARMGIRRVRLTGGE
PLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPLREAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAAG
AGYASLKLNVVVMRGVNDEEASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPAR
YWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVELAVAIRRALGDKPEGHRFTEPG
NGATLLSMMGIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=309, Percent_Identity=36.8932038834951, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI22027536, Length=309, Percent_Identity=36.8932038834951, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI1786999, Length=335, Percent_Identity=37.6119402985075, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI32566331, Length=316, Percent_Identity=37.0253164556962, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32566329, Length=316, Percent_Identity=37.0253164556962, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17561210, Length=314, Percent_Identity=35.9872611464968, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI28574490, Length=321, Percent_Identity=37.3831775700935, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574488, Length=321, Percent_Identity=37.3831775700935, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35776; Mature: 35644

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEEL
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHH
ERITSVFARMGIRRVRLTGGEPLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPL
HHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
REAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAAGAGYASLKLNVVVMRGVNDE
HHCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCH
EASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
RYWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVEL
HHHCCCCCCEEECCHHHHHHCCCCCEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCHHH
AVAIRRALGDKPEGHRFTEPGNGATLLSMMGIGG
HHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCCC
>Mature Secondary Structure 
TTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEEL
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHH
ERITSVFARMGIRRVRLTGGEPLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPL
HHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
REAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAAGAGYASLKLNVVVMRGVNDE
HHCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCH
EASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
RYWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVEL
HHHCCCCCCEEECCHHHHHHCCCCCEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCHHH
AVAIRRALGDKPEGHRFTEPGNGATLLSMMGIGG
HHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA