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The map label for this gene is pyrE [H]

Identifier: 108757628

GI number: 108757628

Start: 5814221

End: 5814787

Strand: Reverse

Name: pyrE [H]

Synonym: MXAN_4633

Alternate gene names: 108757628

Gene position: 5814787-5814221 (Counterclockwise)

Preceding gene: 108760713

Following gene: 108762327

Centisome position: 63.62

GC content: 70.02

Gene sequence:

>567_bases
ATGGCGGAACCTCTCGTGCGCGACCGTGCCCGGCTGTTGGAGCTGCTCACCGAGCGCTCCTTCGAGCAGCGCCGCGTGGT
GCTCTCGTCCGGCAAGGAGTCGGACTTCTACATCGACTGCAAGCGCACGGCGCTGCTGGCCGAGGGCCACTTTCTCATTG
GCCGGCTGTTCCTGGATGCCATCCGGCGCGAGGCCCCGGAGGCCGTGGGCGTGGGCGGACTGACGCTGGGTGCCGACCCG
CTGGCGTCCGCGGTGAGCCTCACTGGCTACCTGTCCGGCACGCCGCTGGCGGCCTTCATCGTGCGCAAGGAGCCCAAGGG
GCACGGCACGGGGCAGTGGATTGAAGGCCTGAGCGGGCTGGGGCAGGGCGCGGCGGTGGCCATCGTGGAGGACGTCGTCA
CGACGGGAGCCTCCACGCTGAAGGCCATCGAGCGGGCCCAGTTGGAGGGCCTGAAGGTGCTGGGCGCCTTCGCGCTGGTG
GACCGGTTGGAGGGTGGGCGTGAAGCCGTGGAGGCCTCGGGTCACCGGCTCCACACGCTCTTCACCCGCAAGGACTTCAT
TCCGTGA

Upstream 100 bases:

>100_bases
GGACGTGTTCGCCGCGCTGGATGAGTCGCGCAAGGCGGAGCTCCTGATGCAGCTCCGCTACTCGTCCGAGCTGGTCACCT
ATCTGGAGGGGCTGTAAGCC

Downstream 100 bases:

>100_bases
GGCGTCCGTTTCTCACCGCGGCGCTGCTGGGGCTGCTCGCGGGCTGTGTCACCACGCCGCCCACCGCCATCAGTGATCCG
CCGCCGTCGCTGCCGGACGA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MAEPLVRDRARLLELLTERSFEQRRVVLSSGKESDFYIDCKRTALLAEGHFLIGRLFLDAIRREAPEAVGVGGLTLGADP
LASAVSLTGYLSGTPLAAFIVRKEPKGHGTGQWIEGLSGLGQGAAVAIVEDVVTTGASTLKAIERAQLEGLKVLGAFALV
DRLEGGREAVEASGHRLHTLFTRKDFIP

Sequences:

>Translated_188_residues
MAEPLVRDRARLLELLTERSFEQRRVVLSSGKESDFYIDCKRTALLAEGHFLIGRLFLDAIRREAPEAVGVGGLTLGADP
LASAVSLTGYLSGTPLAAFIVRKEPKGHGTGQWIEGLSGLGQGAAVAIVEDVVTTGASTLKAIERAQLEGLKVLGAFALV
DRLEGGREAVEASGHRLHTLFTRKDFIP
>Mature_187_residues
AEPLVRDRARLLELLTERSFEQRRVVLSSGKESDFYIDCKRTALLAEGHFLIGRLFLDAIRREAPEAVGVGGLTLGADPL
ASAVSLTGYLSGTPLAAFIVRKEPKGHGTGQWIEGLSGLGQGAAVAIVEDVVTTGASTLKAIERAQLEGLKVLGAFALVD
RLEGGREAVEASGHRLHTLFTRKDFIP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=168, Percent_Identity=34.5238095238095, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17554964, Length=177, Percent_Identity=34.4632768361582, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17933654, Length=174, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20119; Mature: 19988

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPLVRDRARLLELLTERSFEQRRVVLSSGKESDFYIDCKRTALLAEGHFLIGRLFLDA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECHHEEHHCCHHHHHHHHHHH
IRREAPEAVGVGGLTLGADPLASAVSLTGYLSGTPLAAFIVRKEPKGHGTGQWIEGLSGL
HHHHCCHHHCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCC
GQGAAVAIVEDVVTTGASTLKAIERAQLEGLKVLGAFALVDRLEGGREAVEASGHRLHTL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEE
FTRKDFIP
HHHHCCCC
>Mature Secondary Structure 
AEPLVRDRARLLELLTERSFEQRRVVLSSGKESDFYIDCKRTALLAEGHFLIGRLFLDA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECHHEEHHCCHHHHHHHHHHH
IRREAPEAVGVGGLTLGADPLASAVSLTGYLSGTPLAAFIVRKEPKGHGTGQWIEGLSGL
HHHHCCHHHCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCC
GQGAAVAIVEDVVTTGASTLKAIERAQLEGLKVLGAFALVDRLEGGREAVEASGHRLHTL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEE
FTRKDFIP
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA