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The map label for this gene is thrS [H]

Identifier: 108757584

GI number: 108757584

Start: 2732618

End: 2733820

Strand: Reverse

Name: thrS [H]

Synonym: MXAN_2352

Alternate gene names: 108757584

Gene position: 2733820-2732618 (Counterclockwise)

Preceding gene: 108760172

Following gene: 108763223

Centisome position: 29.91

GC content: 71.9

Gene sequence:

>1203_bases
ATGCTTGACGAACACGACCACCGCGCGCTGGGCCAACGCCTGGACCTCTTCCACCTGCAGGAAGAGGCACCCGGCATGGT
GTTCTGGCACCCGCGCGGACTGGTGCTGTACCGGCTGCTGGAGGAGCACGTCCGCCAGCGCATGCGCCGCGAGGGCTACC
AGGAAGTCCGCACCCCACAGCTCTACGCGCAACCCTTGTGGGAGCGCAGCGGCCACTGGGACAACTTCCGGGAGAACATG
TTCCTGGTGGAGGACGGCGCGCGGCACCTGGGCGTGAAGCCGGTGAGCTGCCCCGGCCACATCGAACTGGTGCAGCGCAT
GGCGCCCAGCTACCGCGACCTGCCGCTGCGCCTGGGCGAGTTCGGCCTGGTGCACCGCGCAGAACCCGGCGGCGCGCTCC
ATGGCCTGTTCCGCCTGCGGCAGTTCACCCAGGATGACGGCCACATCTTCTGCGCCGAGCCGCAGGTGGTGCCGGAGGTC
GTCCGCTTCGCCCGCTCGCTGAAGGACTTCTACGCGGGCTTCGGCTTCGACGACGTCCAGGTGGCCTTCTCCGGCCGGCC
CGCGTCACGCGCAGGGCGCGATGAGCTCTGGGACAAGGCCGAGTCCTGGCTCCTCCTCGCGGCGAAGGAAGCGGGGCTCC
AGTGCCACATGCAGCCGGGCGAGGGGGCATTCTACGGGCCCAAGCTGGAGTTCGTCCTGAAGGACCGGCTGGGGCGCGCG
TGGCAGTGCGGAACCATCCAACTGGACCTCGTGCTGCCGGAGCGCTTCGACCTCCACTACGTCGACGCCTCCGGGGCCCG
CGTCCGTCCGGTGATGCTTCACCGCGCGCTGCTCGGCAGCCTGGAGCGCTTCATCGGCGTCATGCTGGAACACCACGGCG
GCGCGCTGCCGCCCTGGCTGGCGCCGCAGCAGGTGGTGGTGGCCTCCGTGGGTGAAGGCGCGGCCGACTACGCCGAGCGC
TTCGCCGCGAAGCTCCAGGAGGCGGGCTGCCGCGCCAGCGTGGACCGGCGGGGTGAATCCCTGTCCCGCAAGGTCCTGGA
TGCCCACGCGGCGGGCGTCCCGTGGCTGGTGGTGGCGGGCGCACGCGAGGTGGCCGCGGGCAACGTCCGCCTGCGGCAGC
GGGACGGCGCGCAGCGGGACGTCCCGTGGGAGGACGCCGCGGCGGAGCTCGTCGCATCGTGCCGTCCGGCCCCGAACGCC
TGA

Upstream 100 bases:

>100_bases
GCACGGTTCCCTGCCCCGCCTTCTCCGGCCGGGGCAACCGTGCGCTCGCTCAGCGCTCCGACCGGATGGCGTTTCACCCT
TCCGAATCGGAGACGAAGCA

Downstream 100 bases:

>100_bases
GGGTGACACCAGGGCGCGGGCGGTGAGAAACGCCGCACCGCTCGCGCCCCGTCGCTTCAGACCTGCTGGAGCCGCTCCAG
CACCTCGCCCGCGTGCAGGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQLYAQPLWERSGHWDNFRENM
FLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGEFGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEV
VRFARSLKDFYAGFGFDDVQVAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRA
WQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWLAPQQVVVASVGEGAADYAER
FAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAGAREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA

Sequences:

>Translated_400_residues
MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQLYAQPLWERSGHWDNFRENM
FLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGEFGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEV
VRFARSLKDFYAGFGFDDVQVAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRA
WQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWLAPQQVVVASVGEGAADYAER
FAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAGAREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA
>Mature_400_residues
MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQLYAQPLWERSGHWDNFRENM
FLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGEFGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEV
VRFARSLKDFYAGFGFDDVQVAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRA
WQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWLAPQQVVVASVGEGAADYAER
FAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAGAREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=373, Percent_Identity=41.5549597855228, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI38570111, Length=373, Percent_Identity=39.9463806970509, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI20070344, Length=389, Percent_Identity=42.9305912596401, Blast_Score=298, Evalue=7e-81,
Organism=Escherichia coli, GI1788013, Length=371, Percent_Identity=48.2479784366577, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71984184, Length=376, Percent_Identity=42.0212765957447, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI71984192, Length=376, Percent_Identity=42.0212765957447, Blast_Score=327, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6322112, Length=373, Percent_Identity=42.627345844504, Blast_Score=322, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=35.264483627204, Blast_Score=258, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24583842, Length=389, Percent_Identity=40.6169665809769, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI28574141, Length=389, Percent_Identity=40.6169665809769, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24583839, Length=389, Percent_Identity=40.6169665809769, Blast_Score=311, Evalue=4e-85,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 44896; Mature: 44896

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQ
CCCCCHHHHHHHHHHHHEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHCCCH
LYAQPLWERSGHWDNFRENMFLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGE
HHHHHHHHCCCCCCCHHCCEEEEECCCHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCC
FGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEVVRFARSLKDFYAGFGFDDVQ
CCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEE
VAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRA
EEECCCCCCCCCHHHHHHHHHHEEEEEEECCCCEEEECCCCCCEECCCHHHHHHHHCCCC
WQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWL
EECCEEEEEEECCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
APQQVVVASVGEGAADYAERFAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAG
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
AREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA
CHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQ
CCCCCHHHHHHHHHHHHEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHCCCH
LYAQPLWERSGHWDNFRENMFLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGE
HHHHHHHHCCCCCCCHHCCEEEEECCCHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCC
FGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEVVRFARSLKDFYAGFGFDDVQ
CCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEE
VAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRA
EEECCCCCCCCCHHHHHHHHHHEEEEEEECCCCEEEECCCCCCEECCCHHHHHHHHCCCC
WQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWL
EECCEEEEEEECCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
APQQVVVASVGEGAADYAERFAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAG
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
AREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA
CHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA