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The map label for this gene is serS

Identifier: 108757304

GI number: 108757304

Start: 2271375

End: 2272655

Strand: Reverse

Name: serS

Synonym: MXAN_1941

Alternate gene names: 108757304

Gene position: 2272655-2271375 (Counterclockwise)

Preceding gene: 108761475

Following gene: 108758559

Centisome position: 24.87

GC content: 66.51

Gene sequence:

>1281_bases
ATGCTGGACCTCCGGAACGTTGCGCAGAACTTCGATGCGGTGGTCGCCCGGCTCAAGACGCGGGGCGGCAACCTGGATTT
GGGCCCCTTCCAGCGGCTCTTCGCCGAGCGCCGCGAGCTGTATGTCTCCGTGGAGTCGCTGGCCGCGCGCCGCAATGCCG
CCAACGAGGAGATGAAGCGCAAGGCGAAGGAGGACCCGAAGGCGCTCGACGCGCTCCGCGGTGACCTCCGCGCCGTCTCC
CAGGAAATCAAGGAGAAGGAAGCGCGCCTCAAGGACGTGGAGGAGGAGCTCAACCGCATCCTCCTGCTCATCCCCAACGT
GCCCCATGAGTCCGTCCCCGAGGGCGGCGGCGCCGAGGACAACGTCCAGGTGAGCATCTGGGGACAGAAGCCCGACCTGC
TCTTCGCCCCCAAGCAGCACTTCGAGCTGGGTGAGAAGCTGGGCATGCTCGACTTCGAGCGCGCCGCCAAGGTGTCTGGC
AGCCGCTTCACCTTCTACAAGGGCGCACTGGCCCGGCTGGAGCGGGCGCTCGTCACCTTCATGATCGACGTGCACACCAG
CAAGGGCTACACGGAGCTGCTCCCGCCCTACTTGGTGCTGCGCGAGACGATGATGGGCACCGGTCAGCTCCCCAAGTTCG
AGGACGACGCCTTCAAGACGTTGGGCGAGCCGGAGCGCTTCCTCATCCCCACCGCGGAAGTGCCCGTCACCAACTACCAC
GCGGACGAAATCCTCGAGGGCGAGTCCCTGCCCATCCGCTACTGCGCCTTCAGCCCCAGCTTCCGGGCCGAGGCGGGCGC
CGCCGGCAAGGACACCCGCGGCCTCATCCGTCAGCACCAGTTCCACAAGGTGGAGCTGGTGAAGTTCGCCCACCAGGAGA
AGAGCCTGGACGAACTCGAGGCCATGACGGACGACGCCTGCGACATCCTCCGCCGCCTGGGCATCCACCACCGCGTCATG
CTCCTGTGCACCGGAGACATGGGCTTCGCCGCCCGGAAGACGTACGACATCGAGGTCTGGCTCCCCGGACAGAACAGCTA
CCGGGAGATTTCGTCCTGCTCTGACTGCGGCGACTTCCAGGCCCGCCGGGCGAAGATTCGCTACCGGGCCCAGAGGGGGG
ACAAGCCCCAGCTCGCCCACACGCTCAACGGCAGCGGCCTGGCGGTAGGCCGGACGACCATCGCCATCCTGGAGAACTAC
CAGCGCGAGGACGGAAGCGTGGCCATTCCGGAGGCGTTGGTGCCGTACATGGGCGGCTTGAAGGAACTGAAACCGATTTG
A

Upstream 100 bases:

>100_bases
CACGGAGTCAGGGCGGAGGGGGGTGCGGCGTCCGGCCTTGAGCACCCCAGACGTGAGGAACCTTGCTGGCCTCACCGGGG
GTGACTACAAGGCGTGCTCC

Downstream 100 bases:

>100_bases
GTCTGAATCCGGCTTGCAACGCGCGAAGAATCAGGTAGAAGGGCGGCCCCACGGACGTCGGTCCGCGGGGTGCCAAGTCG
GCCCCGGTGGTATGGAGGCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKRKAKEDPKALDALRGDLRAVS
QEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAEDNVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSG
SRFTFYKGALARLERALVTFMIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYH
ADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELEAMTDDACDILRRLGIHHRVM
LLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENY
QREDGSVAIPEALVPYMGGLKELKPI

Sequences:

>Translated_426_residues
MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKRKAKEDPKALDALRGDLRAVS
QEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAEDNVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSG
SRFTFYKGALARLERALVTFMIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYH
ADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELEAMTDDACDILRRLGIHHRVM
LLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENY
QREDGSVAIPEALVPYMGGLKELKPI
>Mature_426_residues
MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKRKAKEDPKALDALRGDLRAVS
QEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAEDNVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSG
SRFTFYKGALARLERALVTFMIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYH
ADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELEAMTDDACDILRRLGIHHRVM
LLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENY
QREDGSVAIPEALVPYMGGLKELKPI

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=368, Percent_Identity=36.4130434782609, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI8923421, Length=434, Percent_Identity=33.1797235023041, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI225579074, Length=438, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=47.4299065420561, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539260, Length=333, Percent_Identity=34.2342342342342, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=31.5315315315315, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=386, Percent_Identity=34.7150259067358, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=395, Percent_Identity=29.620253164557, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=353, Percent_Identity=33.7110481586402, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17737985, Length=280, Percent_Identity=34.2857142857143, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MYXXD (Q1DAZ4)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630179.1
- ProteinModelPortal:   Q1DAZ4
- SMR:   Q1DAZ4
- STRING:   Q1DAZ4
- GeneID:   4101628
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1941
- TIGR:   MXAN_1941
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q1DAZ4
- ProtClustDB:   PRK05431
- BioCyc:   MXAN246197:MXAN_1941-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47838; Mature: 47838

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKR
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KAKEDPKALDALRGDLRAVSQEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAED
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCC
NVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSGSRFTFYKGALARLERALVTF
CEEEEEECCCCCEEECCHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
MIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYH
HEEECCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCC
ADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELE
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AMTDDACDILRRLGIHHRVMLLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCHHH
ARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENYQREDGSVAIPEALVPYMGGL
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHCCCCCCEECHHHHHHHHCCH
KELKPI
HHCCCC
>Mature Secondary Structure
MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKR
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
KAKEDPKALDALRGDLRAVSQEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAED
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCC
NVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSGSRFTFYKGALARLERALVTF
CEEEEEECCCCCEEECCHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
MIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYH
HEEECCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCC
ADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELE
HHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AMTDDACDILRRLGIHHRVMLLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCHHH
ARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENYQREDGSVAIPEALVPYMGGL
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHCCCCCCEECHHHHHHHHCCH
KELKPI
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA