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The map label for this gene is tetA [H]

Identifier: 108757274

GI number: 108757274

Start: 2957914

End: 2959197

Strand: Direct

Name: tetA [H]

Synonym: MXAN_2542

Alternate gene names: 108757274

Gene position: 2957914-2959197 (Clockwise)

Preceding gene: 108757991

Following gene: 108762199

Centisome position: 32.36

GC content: 71.26

Gene sequence:

>1284_bases
GTGCGGCGGGCGGCGTCACTCCGTGTCGTCTTCGGAATCGTGGCGCTGGACCTCATCGGGTTCGGCATCCTGATTCCCCA
GTTGGGGGTGTACGGCGTGCGGTTCGGTGCCTCGCCCTTCACGGTGGGGTTGCTCATCTCCGTCTTCTCGCTGATGCAGC
TGGTGTCGGCCCCGATACTGGGCCGGCTCAGCGACCGGTACGGCCGCCGGCCGGTGCTGCTGGTGAGCCAGGTGGGCTCG
CTGCTGGCGTACCTACTGTTCGCCTTCGCGCAGTCTCTGCCGCTGCTCTTCCTGGCGCGTGTCATCGACGGCATCTCCGG
TGGCAACATCTCCACCGCACAGGCCGTGGTGGCGGACATCACCACGCCGAAGGACAGGGCGCGGGGTATGGGAGTCATTG
GCGCGGCCTTCGGGCTGGGCTTCGTGCTGGGACCGGCGCTGGGCGGCTTCCTGGGCGCCTGGGGTGGCAACCTCGCCATC
GGTCTGTTCGCGGCGGGGCTGGTGGCCATCAACCTGACGGGCACGTACTTCTACCTGCCGGAGACGCGGGTGGAGGGGCG
CCCGGGGGAAGGGCACGCGCGCACGCTGAAGGGCGCCACGCTGGCCATGAGCCTGCCCGTGGTGGGGCGCTGCCTGGTGC
TGATGCTGGTGTTCACCACCGCCTTCGCGCAGATGGAAGGCACCTTCTCCGTCTACCTGCTGACGCGCTTCCTGTCGTCC
GGGCCGGTGCCGCTCCAGGAAGGCGGGCTGTTCCTCCGGGCGGCGGTGACGGACCTGGACGTGCTGCGCGAGGCCAGCCT
GCGCTCCGGTTGGCTCTTCGCGGCGATTGGGGTGATTTCCGCGGGGGTGCAGGGCGGCCTGGTTCGCCGGCTGACGGGTG
GGCCCGGGAGCGCGCCAGGGCGCGAGGCGCTGCTGGCCACGGTGGGCTTCGGACTGACGGCGGCGGGGCTGGCCCTGTTG
CCCGTAGCGCCGGATTATGCGTGGCTGTTCCCGGTGATGGGGTTGTTGGCGGTGGGGTCGGCGCTGGTGACACCGTGTCT
GTCCGCCCTGGTATCTCTGCATGCCCCGCCGGAGCGGCTGGGGGCGGTGCTGGGGGCGTACCAGGCCTTCGGCTCGCTGG
GGCGGATTCTGGGGCCGGCGCTGGGGGGCTGGCTCTTCACCCGGCTGGGGCCCGCGGCCCCGTACGGGACGGCGGCGGGC
ATGGTGGCGATGGCGGGGCTCCTGGGATTGTCCCTGGTGGCCCAGACGAGAATGGCAGGCGCGGGGGCCGAGCAAAGGTC
CTAA

Upstream 100 bases:

>100_bases
AAAGCCCTTCGGACCCGGGACTTCTCCCCCATTCGAGCCGCCGGGGCGCTATCTTCGCGCTCCGGCGGTTTTTCTTTTTT
CAGCAAAGGGGCAACTGGTG

Downstream 100 bases:

>100_bases
GATGGAGGACATGGTGGGGACGCAGCCGCAGCCAGTGACGATTGCCTTCGATGTCATGGGAACGGACCACGGCCCGGCCG
AGGTGGTCCGGGGAGCGGCG

Product: putative multidrug resistance protein

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPILGRLSDRYGRRPVLLVSQVGS
LLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADITTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAI
GLFAAGLVAINLTGTYFYLPETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSS
GPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPGREALLATVGFGLTAAGLALL
PVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERLGAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAG
MVAMAGLLGLSLVAQTRMAGAGAEQRS

Sequences:

>Translated_427_residues
MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPILGRLSDRYGRRPVLLVSQVGS
LLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADITTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAI
GLFAAGLVAINLTGTYFYLPETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSS
GPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPGREALLATVGFGLTAAGLALL
PVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERLGAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAG
MVAMAGLLGLSLVAQTRMAGAGAEQRS
>Mature_427_residues
MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPILGRLSDRYGRRPVLLVSQVGS
LLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADITTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAI
GLFAAGLVAINLTGTYFYLPETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSS
GPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPGREALLATVGFGLTAAGLALL
PVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERLGAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAG
MVAMAGLLGLSLVAQTRMAGAGAEQRS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=380, Percent_Identity=31.0526315789474, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI225703102, Length=380, Percent_Identity=31.0526315789474, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI217416366, Length=195, Percent_Identity=34.3589743589744, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI94721311, Length=446, Percent_Identity=26.2331838565022, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI39753965, Length=379, Percent_Identity=25.8575197889182, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI87081738, Length=149, Percent_Identity=32.8859060402685, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551570, Length=364, Percent_Identity=27.7472527472527, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71996331, Length=395, Percent_Identity=23.0379746835443, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17738085, Length=364, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21357569, Length=387, Percent_Identity=28.1653746770026, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221513297, Length=380, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656463, Length=387, Percent_Identity=28.1653746770026, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24656468, Length=387, Percent_Identity=28.1653746770026, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161080926, Length=387, Percent_Identity=28.1653746770026, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161080924, Length=387, Percent_Identity=28.1653746770026, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24667557, Length=142, Percent_Identity=33.0985915492958, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667561, Length=142, Percent_Identity=32.3943661971831, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43750; Mature: 43750

Theoretical pI: Translated: 10.80; Mature: 10.80

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
GRLSDRYGRRPVLLVSQVGSLLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
TTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAIGLFAAGLVAINLTGTYFYLP
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCEEEECC
ETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSS
CCCCCCCCCCCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
GPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPG
CCCCHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHEEECCCCCCCCC
REALLATVGFGLTAAGLALLPVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERL
HHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAGMVAMAGLLGLSLVAQTRMAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
AGAEQRS
CCCCCCC
>Mature Secondary Structure
MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
GRLSDRYGRRPVLLVSQVGSLLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
TTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAIGLFAAGLVAINLTGTYFYLP
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCEEEECC
ETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSS
CCCCCCCCCCCCHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
GPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPG
CCCCHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHEEECCCCCCCCC
REALLATVGFGLTAAGLALLPVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERL
HHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAGMVAMAGLLGLSLVAQTRMAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
AGAEQRS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]