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The map label for this gene is lcrD [H]

Identifier: 108757145

GI number: 108757145

Start: 2864565

End: 2866688

Strand: Direct

Name: lcrD [H]

Synonym: MXAN_2463

Alternate gene names: 108757145

Gene position: 2864565-2866688 (Clockwise)

Preceding gene: 108757500

Following gene: 108761209

Centisome position: 31.34

GC content: 66.05

Gene sequence:

>2124_bases
ATGGCTGCCACCAATTCGAACAGCTTCCTCTCCAAGTACTCCGACATCGTCCTCGCCGTGGTGGTCGTGGCCATCGTCGG
GATGATGATCGTCCCGCTGCCCACGCTGCTGCTGGACGTGCTGCTGACGCTGAACATCAGCATCTCGGTGGTGCTGCTCC
TCGTATCCCTCTACGTGCCAGCGGCGCTGCACCTGTCGGTGTTCCCGACGCTGCTGCTCATCACCACGATGTTCCGGTTG
GCCCTCACCATCTCCACCACGCGTCTCATCCTCCTCACCGGTGACCCGGGAGAGGTGGTGGTGGCGTTCGGAAACTTCGT
GGTGCAGGGCAACTTCGTCGTCGGCGCCATCCTCTTCATCATCCTGGTCATCGTGAACTTCATCGTGATTTCCAAGGGCT
CGGAGCGCGTCGCCGAAGTGGCCGCCCGCTTCACCCTGGACGCGATGCCCGGAAAGCAGATGTCCATCGACGCCGACCTG
CGGGCCGGCTCCATCGACCAGGACCAGGGCAAGAAGAAGCGCCGCGACCTGGAGCGTGAGAGCCAGCTCTTCGGCGCCAT
GGACGGCGCCATGAAGTTCGTGAAGGGCGACGCCATCGCGAGCATCATCATCACCGTCGTCAACATCGTCGGTGGCCTCA
TCATCGGCGTGACGCAGAAGGGCATGTCCGCTGGCGACGCGGCGCAGAAGTACACGCTGCTCACCATCGGTGACGGTCTG
GTCGGCATGATTCCCGCCATCCTCGTCTCCACCTGCGCCGGTATCATCGTGACGCGCGTGGCGGGTGAGGAAGAGGGCAA
TCACCTGGGCATGGACATGGGCTCCCAGCTGACGGCCTACCCGAAGGCCATCGCCATTGCCGCCGGCATGCTCATCGTCC
TGGGCCTGGTGCCCGGTCTGCCCAAGATTCCCTTCTTCCTGCTGGGCATCGGCGCGGGCCTGGGCGCCTGGACGATGCTG
AAGAAGCAGCAGCAGGCCGTGGAGGCGGAGGATGCCGGCCCGGCCATGGAGACGGACCTGGGCACGCCCATGGCATCGGA
GCCCGCGCCCAAGGAAGCCCTCAATCCGGACTCCGAGCTATTCATCCCCGTCGTCACGCCCATCGTCCTGGAAGTCTCCG
ACGCGCTGGTCCCCTTCGTGGACTCGCGCCAGGACAACGGGAAGTTCCTCTTCGAACTCATCCCGTTCATGCGTGATGGC
CTCTTCGTGGAACTGGGCGTGCGCTTCCCAGGCGTGCGTGCGCGTGGCAACGGCTCGCTGCCGCCGGGCGCGTACCAGAT
TCAAATCAACGAGGTGCCCGTCGTCACCGGCCAGGCCACGCTGGGCCACGTCCTGGTGAACGACACGGTGGACCGGCTGC
GGCTGATGAACATCCAGGGCTTCGAGGCCGTGAACCCCGCCACCCGGCAGCCCGCCGCCTGGGTCCCCGAGCAGTACCGC
GACACGCTGGAGGCCGCCGGCCTCACGACGTGGGACGTGCCCGGCTACATCATCCTGCACACCGCCGCCGTGCTGCGGCG
CAACGCCCGTGAGTTCGTTGGCGTGCAGGAGACGCAGACGATGCTGGAGCAGTTGGAGAAGGCCTTCCCCGCCATCGTGA
AGGAGGTCGTCCCCAAGGTCGTCAACGTGCTGAAGCTGACGGACATCCTCCAGCGTCTGGTGGAGGAGGAGATCTCCATC
CGTGACTTGCGCGGCATCCTCCAGGCCCTGGCCGAGTACGGGCAGGTGGAGGCGGACAACGTCATGCTCACCGAGCATGT
CCGCGCGGCCCAGCGCCGCTACATCTCCCACAAGTACGCGCGTGGCACCGGCACCCTGGTGGTGTACCTGTTGGACCCGA
ACATCGAGGACGCCATCCGCGGCTCGGTGAAGCGGACCTCCGCGGGCGCGCACCTGGCGCTGGAGCCGGAGCTGGCGCAG
GAAATCGTCCAGGCCGTGCGTTCGGAGTGTGGCCACCTGCCGCCCAGCGCGCAGCGGCCCGTCATCCTCACGGCCATGGA
CATCCGCCGCTACGTCCGCAAGCTGCTGGAGTACGAGTTCAACCCGTCGTTCTCCGTGCTCAGCTACCAGGAGCTGTCGC
CCGAGCTGAACATCCAGCCCGTGGCGCGCATCTCCACGCGATAG

Upstream 100 bases:

>100_bases
CGCCCGAGGGAGAACGGCGGGTTTCGCCGTGGGGAGGGGCCCTTCGCGACGCCCCCCCTGACAGAAGGCACCCGGGTTGG
CCTAGGATGCCTGACCGCTG

Downstream 100 bases:

>100_bases
CCGCGGATGGACCTCCGCCCGCGCGTGACAGGGACGCGCGGGCGGAAGGAATGCCCTCTCATGAGGGCAGGGGCCTGCTC
GCGATGCTAGGCGCCCGCGA

Product: type III secretion protein LcrD/AscV

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MAATNSNSFLSKYSDIVLAVVVVAIVGMMIVPLPTLLLDVLLTLNISISVVLLLVSLYVPAALHLSVFPTLLLITTMFRL
ALTISTTRLILLTGDPGEVVVAFGNFVVQGNFVVGAILFIILVIVNFIVISKGSERVAEVAARFTLDAMPGKQMSIDADL
RAGSIDQDQGKKKRRDLERESQLFGAMDGAMKFVKGDAIASIIITVVNIVGGLIIGVTQKGMSAGDAAQKYTLLTIGDGL
VGMIPAILVSTCAGIIVTRVAGEEEGNHLGMDMGSQLTAYPKAIAIAAGMLIVLGLVPGLPKIPFFLLGIGAGLGAWTML
KKQQQAVEAEDAGPAMETDLGTPMASEPAPKEALNPDSELFIPVVTPIVLEVSDALVPFVDSRQDNGKFLFELIPFMRDG
LFVELGVRFPGVRARGNGSLPPGAYQIQINEVPVVTGQATLGHVLVNDTVDRLRLMNIQGFEAVNPATRQPAAWVPEQYR
DTLEAAGLTTWDVPGYIILHTAAVLRRNAREFVGVQETQTMLEQLEKAFPAIVKEVVPKVVNVLKLTDILQRLVEEEISI
RDLRGILQALAEYGQVEADNVMLTEHVRAAQRRYISHKYARGTGTLVVYLLDPNIEDAIRGSVKRTSAGAHLALEPELAQ
EIVQAVRSECGHLPPSAQRPVILTAMDIRRYVRKLLEYEFNPSFSVLSYQELSPELNIQPVARISTR

Sequences:

>Translated_707_residues
MAATNSNSFLSKYSDIVLAVVVVAIVGMMIVPLPTLLLDVLLTLNISISVVLLLVSLYVPAALHLSVFPTLLLITTMFRL
ALTISTTRLILLTGDPGEVVVAFGNFVVQGNFVVGAILFIILVIVNFIVISKGSERVAEVAARFTLDAMPGKQMSIDADL
RAGSIDQDQGKKKRRDLERESQLFGAMDGAMKFVKGDAIASIIITVVNIVGGLIIGVTQKGMSAGDAAQKYTLLTIGDGL
VGMIPAILVSTCAGIIVTRVAGEEEGNHLGMDMGSQLTAYPKAIAIAAGMLIVLGLVPGLPKIPFFLLGIGAGLGAWTML
KKQQQAVEAEDAGPAMETDLGTPMASEPAPKEALNPDSELFIPVVTPIVLEVSDALVPFVDSRQDNGKFLFELIPFMRDG
LFVELGVRFPGVRARGNGSLPPGAYQIQINEVPVVTGQATLGHVLVNDTVDRLRLMNIQGFEAVNPATRQPAAWVPEQYR
DTLEAAGLTTWDVPGYIILHTAAVLRRNAREFVGVQETQTMLEQLEKAFPAIVKEVVPKVVNVLKLTDILQRLVEEEISI
RDLRGILQALAEYGQVEADNVMLTEHVRAAQRRYISHKYARGTGTLVVYLLDPNIEDAIRGSVKRTSAGAHLALEPELAQ
EIVQAVRSECGHLPPSAQRPVILTAMDIRRYVRKLLEYEFNPSFSVLSYQELSPELNIQPVARISTR
>Mature_706_residues
AATNSNSFLSKYSDIVLAVVVVAIVGMMIVPLPTLLLDVLLTLNISISVVLLLVSLYVPAALHLSVFPTLLLITTMFRLA
LTISTTRLILLTGDPGEVVVAFGNFVVQGNFVVGAILFIILVIVNFIVISKGSERVAEVAARFTLDAMPGKQMSIDADLR
AGSIDQDQGKKKRRDLERESQLFGAMDGAMKFVKGDAIASIIITVVNIVGGLIIGVTQKGMSAGDAAQKYTLLTIGDGLV
GMIPAILVSTCAGIIVTRVAGEEEGNHLGMDMGSQLTAYPKAIAIAAGMLIVLGLVPGLPKIPFFLLGIGAGLGAWTMLK
KQQQAVEAEDAGPAMETDLGTPMASEPAPKEALNPDSELFIPVVTPIVLEVSDALVPFVDSRQDNGKFLFELIPFMRDGL
FVELGVRFPGVRARGNGSLPPGAYQIQINEVPVVTGQATLGHVLVNDTVDRLRLMNIQGFEAVNPATRQPAAWVPEQYRD
TLEAAGLTTWDVPGYIILHTAAVLRRNAREFVGVQETQTMLEQLEKAFPAIVKEVVPKVVNVLKLTDILQRLVEEEISIR
DLRGILQALAEYGQVEADNVMLTEHVRAAQRRYISHKYARGTGTLVVYLLDPNIEDAIRGSVKRTSAGAHLALEPELAQE
IVQAVRSECGHLPPSAQRPVILTAMDIRRYVRKLLEYEFNPSFSVLSYQELSPELNIQPVARISTR

Specific function: Could be involved in the secretion of the yop virulence proteins [H]

COG id: COG4789

COG function: function code U; Type III secretory pathway, component EscV

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=695, Percent_Identity=37.9856115107914, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001712
- InterPro:   IPR006302 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 76428; Mature: 76296

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00994 FHIPEP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATNSNSFLSKYSDIVLAVVVVAIVGMMIVPLPTLLLDVLLTLNISISVVLLLVSLYVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALHLSVFPTLLLITTMFRLALTISTTRLILLTGDPGEVVVAFGNFVVQGNFVVGAILFI
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCEEEECCHHHHHHHHH
ILVIVNFIVISKGSERVAEVAARFTLDAMPGKQMSIDADLRAGSIDQDQGKKKRRDLERE
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
SQLFGAMDGAMKFVKGDAIASIIITVVNIVGGLIIGVTQKGMSAGDAAQKYTLLTIGDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCHHEEEEEEECCCH
VGMIPAILVSTCAGIIVTRVAGEEEGNHLGMDMGSQLTAYPKAIAIAAGMLIVLGLVPGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PKIPFFLLGIGAGLGAWTMLKKQQQAVEAEDAGPAMETDLGTPMASEPAPKEALNPDSEL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCE
FIPVVTPIVLEVSDALVPFVDSRQDNGKFLFELIPFMRDGLFVELGVRFPGVRARGNGSL
EHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCC
PPGAYQIQINEVPVVTGQATLGHVLVNDTVDRLRLMNIQGFEAVNPATRQPAAWVPEQYR
CCCEEEEEEECEEEEECCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHH
DTLEAAGLTTWDVPGYIILHTAAVLRRNAREFVGVQETQTMLEQLEKAFPAIVKEVVPKV
HHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNVLKLTDILQRLVEEEISIRDLRGILQALAEYGQVEADNVMLTEHVRAAQRRYISHKYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
RGTGTLVVYLLDPNIEDAIRGSVKRTSAGAHLALEPELAQEIVQAVRSECGHLPPSAQRP
CCCCCEEEEEECCCHHHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCC
VILTAMDIRRYVRKLLEYEFNPSFSVLSYQELSPELNIQPVARISTR
EEEEHHHHHHHHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AATNSNSFLSKYSDIVLAVVVVAIVGMMIVPLPTLLLDVLLTLNISISVVLLLVSLYVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALHLSVFPTLLLITTMFRLALTISTTRLILLTGDPGEVVVAFGNFVVQGNFVVGAILFI
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCEEEECCHHHHHHHHH
ILVIVNFIVISKGSERVAEVAARFTLDAMPGKQMSIDADLRAGSIDQDQGKKKRRDLERE
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
SQLFGAMDGAMKFVKGDAIASIIITVVNIVGGLIIGVTQKGMSAGDAAQKYTLLTIGDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCHHEEEEEEECCCH
VGMIPAILVSTCAGIIVTRVAGEEEGNHLGMDMGSQLTAYPKAIAIAAGMLIVLGLVPGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PKIPFFLLGIGAGLGAWTMLKKQQQAVEAEDAGPAMETDLGTPMASEPAPKEALNPDSEL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCE
FIPVVTPIVLEVSDALVPFVDSRQDNGKFLFELIPFMRDGLFVELGVRFPGVRARGNGSL
EHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCC
PPGAYQIQINEVPVVTGQATLGHVLVNDTVDRLRLMNIQGFEAVNPATRQPAAWVPEQYR
CCCEEEEEEECEEEEECCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHH
DTLEAAGLTTWDVPGYIILHTAAVLRRNAREFVGVQETQTMLEQLEKAFPAIVKEVVPKV
HHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNVLKLTDILQRLVEEEISIRDLRGILQALAEYGQVEADNVMLTEHVRAAQRRYISHKYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
RGTGTLVVYLLDPNIEDAIRGSVKRTSAGAHLALEPELAQEIVQAVRSECGHLPPSAQRP
CCCCCEEEEEECCCHHHHHCCCHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCC
VILTAMDIRRYVRKLLEYEFNPSFSVLSYQELSPELNIQPVARISTR
EEEEHHHHHHHHHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11402007 [H]