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The map label for this gene is hisS [H]

Identifier: 108756931

GI number: 108756931

Start: 4440345

End: 4441622

Strand: Direct

Name: hisS [H]

Synonym: MXAN_3725

Alternate gene names: 108756931

Gene position: 4440345-4441622 (Clockwise)

Preceding gene: 108760031

Following gene: 108758898

Centisome position: 48.58

GC content: 67.84

Gene sequence:

>1278_bases
GTGAGTCAGAAGGTCGCGGGCGTCAAGGGCATGAACGATCTCCTCCCTGGGGAGATCGAAATCTGGCAGCACGTGGAGGC
GCAGGCCCGCGAGCTGTTCGGCCGCTTCGGCTACGGTGAGATCCGCACGCCCATGGTGGAGGACACCGCGCTGTTCGTGC
GCAGCGTGGGCGAGGAGACCGACATCGTCGGGAAGGAGATGTACACCTTCAACGACAAGGCGGACCGCAGCCTGTCTCTG
CGCCCGGAAGGCACCGCGCCCGCGGCGCGCGCGTACATCGAGCACTCCATCGCCAATCAGGAGCCGCTCACGCGCTGGTT
CTATGCGGGGCCCATGTTCCGCTACGAGCGGATGAAGACGGGCCGCTACCGCCAGTTCTATCAAATCGGCGCGGAGGCCT
ACGGCGCGAAGGAAGGCGCCCAGGACGTCGAGATGATGGACATGGTGGTGCAGTTCCTGGAGCGGCTGGGGCTCAAGGAC
ATCACCCTGAACATCAACTCGCTGGGGGACGAGGTCTGCCGGCCCACGTACCACGCGAAGTTGGTGGAGTACCTCCAGGC
CCACCGCGAGGCGCTGTGTGGGGACTGCCAGAAGCGCATGGAGAAGAACCCTCTGCGCGTCCTGGACTGCAAGAACGAGA
AGTGCCAGGCCATCGCCGCGGCCGGCCCCAATGTGCTGGAGTCCCTGTGCGAGCCCTGCCGCGCGCACTTCGACGACGTG
CAGCGGAAGCTGACGGCGCTGGGCGTCCGGCACGTCGTGAATCCGCGCATGGTGCGTGGGTTGGACTACTACACGCGCAC
CGTCTTCGAGTTCATTGCCTCGCACCCCGCGCTGGGCACCGCCAGCACCGTGGGCGCCGGTGGCCGCTATGACAAGCTGG
TGAAGAGCCTGGGCGGGCCGGACGCGCCCGCGGTGGGCTTCGCCTGTGGCCTGGACCGGCTGGTGCTGCTGCTCAAAGAG
AGCGGCCAGCAGTTCACCGTGCGGCCGGACGTCTTCGTCGCGGTGGCGGACGCGGGCTCGCACGATGCTGCCCTGGTGCT
GGCCAGCCGCCTGCGCCGGGAGGGACTGCGCGTGGAGTTCGATACCCGCGGAGGCAGCCTCAAGAGCCAGATGAAGCGCG
CGGACAAGAGCAGCGCGGAATTCACCCTGGTGCTGGGCGAGGCCGAGCGCACCAGCGGCCAGGCGAAGCTGAAGCCCATG
GCCGGAGGCGAGCCCATCCCCGTCGCGCTCGACGAGGTCGCCAGGGTGGTTCGGGAGCGTAAGGTCGTTTCGGCATAG

Upstream 100 bases:

>100_bases
CCACCGTCATCCTCCTGTTCGAGCCCAAGCGCGTCACCTGGGACGACAGCCTCCAGGAGGAAGCGGTGGTTCGGCTGGGC
AAGCGAATCGGAGTCATCAC

Downstream 100 bases:

>100_bases
CGTTCTGCGGGGGTGAGAGCAGTATTCCGGGCGATTCTTGCTAAGTCCGAGAAACTGAGGTAGGCGCGTAACCCCTGATA
AACGTTGGGCTATTGGGCCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEETDIVGKEMYTFNDKADRSLSL
RPEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKTGRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKD
ITLNINSLGDEVCRPTYHAKLVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDV
QRKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGPDAPAVGFACGLDRLVLLLKE
SGQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEFDTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPM
AGGEPIPVALDEVARVVRERKVVSA

Sequences:

>Translated_425_residues
MSQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEETDIVGKEMYTFNDKADRSLSL
RPEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKTGRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKD
ITLNINSLGDEVCRPTYHAKLVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDV
QRKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGPDAPAVGFACGLDRLVLLLKE
SGQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEFDTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPM
AGGEPIPVALDEVARVVRERKVVSA
>Mature_424_residues
SQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEETDIVGKEMYTFNDKADRSLSLR
PEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKTGRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKDI
TLNINSLGDEVCRPTYHAKLVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDVQ
RKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGPDAPAVGFACGLDRLVLLLKES
GQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEFDTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPMA
GGEPIPVALDEVARVVRERKVVSA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=424, Percent_Identity=45.9905660377358, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71993686, Length=471, Percent_Identity=25.9023354564756, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71993693, Length=471, Percent_Identity=25.9023354564756, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24643061, Length=491, Percent_Identity=24.4399185336049, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643059, Length=509, Percent_Identity=24.5579567779961, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47022; Mature: 46891

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEET
CCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHH
DIVGKEMYTFNDKADRSLSLRPEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKT
HHCCCHHEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHC
GRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKDITLNINSLGDEVCRPTYHAK
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCHHHHH
LVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHEEHHCCHHHHHHHHHHHHHHHHHH
QRKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCC
DAPAVGFACGLDRLVLLLKESGQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEF
CCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEE
DTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPMAGGEPIPVALDEVARVVRER
ECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
KVVSA
HHCCC
>Mature Secondary Structure 
SQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEET
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHH
DIVGKEMYTFNDKADRSLSLRPEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKT
HHCCCHHEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHC
GRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKDITLNINSLGDEVCRPTYHAK
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCHHHHH
LVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHEEHHCCHHHHHHHHHHHHHHHHHH
QRKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCC
DAPAVGFACGLDRLVLLLKESGQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEF
CCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEE
DTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPMAGGEPIPVALDEVARVVRER
ECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
KVVSA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA