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The map label for this gene is rocF [H]

Identifier: 108563895

GI number: 108563895

Start: 1531330

End: 1532298

Strand: Reverse

Name: rocF [H]

Synonym: HPAG1_1470

Alternate gene names: 108563895

Gene position: 1532298-1531330 (Counterclockwise)

Preceding gene: 108563896

Following gene: 108563894

Centisome position: 95.99

GC content: 39.83

Gene sequence:

>969_bases
ATGATTTTAGTAGGATTGGAAGCGGAATTAGGAGCGTCAAAAAGAGGCACCGATAAAGGGGTTAGGCGTTTGAGAGAGGC
TTTAAGCGCAACGCATGGCGATGTGATTAAAGGCATGCAAACGATCACTCAAGAGCGGTGCGTGCTTTATAAAGAGTTTA
GATACGCTAAGAATTTTGAAGATTACTACCTTTTTTGTAAAGAAAATCTGATCCCTTGCATGAAAGAAGTGTTTGAGAAA
AAAGAATTTCCTTTGATTTTAAGCTCAGAGCATGCGAACATGTTTGGGATTTTCCAAGCCTTTAGGAGCGTTCATAAAGA
CAAAAAAATAGGGATTTTGTATTTAGACGCTCATGCGGATATTCATACGGCTTATGACAGCGATTCAAAGCATATCCACG
GCATGCCCTTAGGCATGGTTTTAAATCGTGTCCGTAGCGGGTTTAATCGCATGAGCGAGAGCGAAGAAAAGGCATGGCAA
AAGCTTTGCTCTTTGGGGTTAGAAAAGGGAGGGTTAGAAATTGATCCTAAATGTTTGGTGTATTTTGGGGTAAGAAGCAC
AGAAAAAAGCGAAAGAGATGTGATTAAGGAATTAGAAATCCCCTTATTTAGCGTGGGTGCGATAAGAGAAAACATGCATG
AAGTGGTTCAAAAAACCAAAGAGTTATTAAAAGCGGTGGATATTATTTACCTTAGCTTGGATTTAGACATTATGGATGGC
AAGCTTTTCACTTCTACCGGCGTGCGTGAAAATAACGGGCTGAGTTTTGATGAATTAAGGCAATTACTGGGCTTGCTTTT
AGAAAATTTTAAAGACCGATTAGGAGCGCTTGAGGTAACCGAATACAACCCCACGGTGAGCGTCAAACACAATAACGAAG
AAGAAAAGCAGGTTTTAGAAATTTTGGATCTCATTATTAAGCGCTGTAAAATTAAAGACAAGAAGCCATCTTTCGCAATG
AGTAGCTGA

Upstream 100 bases:

>100_bases
TCTCACGCTAGTGTTTATGGGGCTTTGCTATGGGGCGTATTATTTGAGTAAGGACAAATGGGGCTATCAGCAAGAAAAAG
GAATTTAAAGGAGTTATAAA

Downstream 100 bases:

>100_bases
TCGCTTTTCAAACCAAACGATAAAAAATTGAAAAAGGGGCGGTGTTTAGATGAAAAATTAAACCACTTTGAGCGTCAAAG
AATGTCTTGTGTGTTTTGAG

Product: arginase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLYKEFRYAKNFEDYYLFCKENLIPCMKEVFEK
KEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSESEEKAWQ
KLCSLGLEKGGLEIDPKCLVYFGVRSTEKSERDVIKELEIPLFSVGAIRENMHEVVQKTKELLKAVDIIYLSLDLDIMDG
KLFTSTGVRENNGLSFDELRQLLGLLLENFKDRLGALEVTEYNPTVSVKHNNEEEKQVLEILDLIIKRCKIKDKKPSFAM
SS

Sequences:

>Translated_322_residues
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLYKEFRYAKNFEDYYLFCKENLIPCMKEVFEK
KEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSESEEKAWQ
KLCSLGLEKGGLEIDPKCLVYFGVRSTEKSERDVIKELEIPLFSVGAIRENMHEVVQKTKELLKAVDIIYLSLDLDIMDG
KLFTSTGVRENNGLSFDELRQLLGLLLENFKDRLGALEVTEYNPTVSVKHNNEEEKQVLEILDLIIKRCKIKDKKPSFAM
SS
>Mature_322_residues
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLYKEFRYAKNFEDYYLFCKENLIPCMKEVFEK
KEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSESEEKAWQ
KLCSLGLEKGGLEIDPKCLVYFGVRSTEKSERDVIKELEIPLFSVGAIRENMHEVVQKTKELLKAVDIIYLSLDLDIMDG
KLFTSTGVRENNGLSFDELRQLLGLLLENFKDRLGALEVTEYNPTVSVKHNNEEEKQVLEILDLIIKRCKIKDKKPSFAM
SS

Specific function: Controls arginine catabolism [H]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI10947139, Length=226, Percent_Identity=26.5486725663717, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4502215, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71996843, Length=237, Percent_Identity=26.5822784810127, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6325146, Length=223, Percent_Identity=27.3542600896861, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24638886, Length=302, Percent_Identity=25.4966887417219, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014033
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.1 [H]

Molecular weight: Translated: 36801; Mature: 36801

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00148 ARGINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLYKEFRYAKNFE
CEEEEECHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHAD
HHEEHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
IHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSESEEKAWQKLCSLGLEKGGLEIDPKCLV
EEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEECCCEEE
YFGVRSTEKSERDVIKELEIPLFSVGAIRENMHEVVQKTKELLKAVDIIYLSLDLDIMDG
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
KLFTSTGVRENNGLSFDELRQLLGLLLENFKDRLGALEVTEYNPTVSVKHNNEEEKQVLE
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHH
ILDLIIKRCKIKDKKPSFAMSS
HHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQTITQERCVLYKEFRYAKNFE
CEEEEECHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHAD
HHEEHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
IHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSESEEKAWQKLCSLGLEKGGLEIDPKCLV
EEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEECCCEEE
YFGVRSTEKSERDVIKELEIPLFSVGAIRENMHEVVQKTKELLKAVDIIYLSLDLDIMDG
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
KLFTSTGVRENNGLSFDELRQLLGLLLENFKDRLGALEVTEYNPTVSVKHNNEEEKQVLE
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHH
ILDLIIKRCKIKDKKPSFAMSS
HHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377 [H]