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The map label for this gene is ilvE [H]

Identifier: 108563872

GI number: 108563872

Start: 1504869

End: 1505891

Strand: Direct

Name: ilvE [H]

Synonym: HPAG1_1447

Alternate gene names: 108563872

Gene position: 1504869-1505891 (Clockwise)

Preceding gene: 108563871

Following gene: 108563874

Centisome position: 94.27

GC content: 44.48

Gene sequence:

>1023_bases
ATGGCAAATTTGGAAAATTTAGACTGGAAAAATTTAGGCTTTAGCTACATTAAAACGGATTTTCGCTTCATCGCTACTTA
TAAAAACGGCTCTTGGTCGCATGGCGAATTGGTGAGCGAAAATGTGTTGCAACTCAGCGAAGGTTCGCCGGTCTTGCACT
ACGGGCAGGCTTGTTTTGAAGGCTTGAAGGCTTACCGCTCTCAAAAGGGGAAGGCTTTACTTTTTCGCCCTTTAGAAAAC
GCCAAACGCTTGCAAACTTCATGCGAAAGACTGCTTATGCCTAAAGTGAGTGAAGAGCTGTTTTTAAGGGCATGCGCTGA
AGTAGTCAAAGCGAATCAAAAATGGCTCGCTCCTTATAAAAGCGGGGCGAGTTTGTATTTGCGCCCTTTTGTCATAGGCG
TAGGGGATAATTTGGGGGTAAAGCCGGCTAATGAATACCTTTTTATCGTGTTTTGTGCGCCTGTGGGGGCGTATTTTAAG
GGGGGTATAGAAAAAAGGGGGGCTAGGTTTATCACCACGGCGTTTGATAGGGCCGCGCCTAAAGGCACCGGAGGGGTGAA
AGTAGGGGGGAATTATGCTGCAAGCCTGTTAGCCCATAAAATGGCTGTAGAGCAAGGCTATGATGATTGCATTTATTTAG
ATCCTGCCACGCACACTAAAATTGAAGAAGTGGGGGCGGCGAATTTTTTTGGCATCACGCATGATAACGCCTTTATCACC
CCGCATTCGCCAAGCATTTTGCCAAGCATTACCAAAAAAAGCTTGATGGTTTTGGCTAAAGAGTATTTGAACCTCAAAGT
AGAAGAGAGGGAAATCCTAATGGATGAGTTGGATGCGTTTAAAGAAGCTGGAGCGTGCGGGACAGCTGCAATCATTACGC
CCATTAAAGAAATCGCGCACAATAACAAGTCTTATTTTTTTGAAACACCGGGCCATATTACTAAACAACTCTATGATTTG
CTTTTATCCATCCAACAAGGCGAACAAAAAGCCCCTAAAGATTGGATTTTTGAAGTTGGCTAA

Upstream 100 bases:

>100_bases
GTGCGCCGAGTTTATGCGTTTCAAATCAGTTACTTGAGGGATTTTTAACCCCTTTTTAGATACAATCGCACCTGAAACTA
TCCATGTTAAAGGTGTGAAA

Downstream 100 bases:

>100_bases
AAGGTTAAAATTTATAGCTGTATGCCGCATAAAATAAGGGCGAAGTCTCAAAGCGTTTGGAGCTAGAAAGCAATCTGGCG
GTGGGTAAGATTTTAAACCC

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSHGELVSENVLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLEN
AKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFK
GGIEKRGARFITTAFDRAAPKGTGGVKVGGNYAASLLAHKMAVEQGYDDCIYLDPATHTKIEEVGAANFFGITHDNAFIT
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIAHNNKSYFFETPGHITKQLYDL
LLSIQQGEQKAPKDWIFEVG

Sequences:

>Translated_340_residues
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSHGELVSENVLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLEN
AKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFK
GGIEKRGARFITTAFDRAAPKGTGGVKVGGNYAASLLAHKMAVEQGYDDCIYLDPATHTKIEEVGAANFFGITHDNAFIT
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIAHNNKSYFFETPGHITKQLYDL
LLSIQQGEQKAPKDWIFEVG
>Mature_339_residues
ANLENLDWKNLGFSYIKTDFRFIATYKNGSWSHGELVSENVLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLENA
KRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKG
GIEKRGARFITTAFDRAAPKGTGGVKVGGNYAASLLAHKMAVEQGYDDCIYLDPATHTKIEEVGAANFFGITHDNAFITP
HSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIAHNNKSYFFETPGHITKQLYDLL
LSIQQGEQKAPKDWIFEVG

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010904, Length=346, Percent_Identity=32.3699421965318, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI38176287, Length=346, Percent_Identity=32.3699421965318, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI296010906, Length=346, Percent_Identity=32.3699421965318, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI50658084, Length=310, Percent_Identity=30.6451612903226, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI258614015, Length=263, Percent_Identity=31.9391634980989, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI296010902, Length=346, Percent_Identity=28.0346820809249, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI296010900, Length=252, Percent_Identity=32.1428571428571, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI48994963, Length=314, Percent_Identity=31.5286624203822, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17568601, Length=310, Percent_Identity=31.9354838709677, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565728, Length=266, Percent_Identity=31.9548872180451, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6322002, Length=318, Percent_Identity=32.3899371069182, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322608, Length=318, Percent_Identity=32.7044025157233, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24641779, Length=341, Percent_Identity=29.3255131964809, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 37688; Mature: 37557

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSHGELVSENVLQLSEGSPVLHYGQACFE
CCCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
GLKAYRSQKGKALLFRPLENAKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKGGIEKRGARFITTAFDRAAP
CCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHCCHHHCCCEEEEHHHHHCCC
KGTGGVKVGGNYAASLLAHKMAVEQGYDDCIYLDPATHTKIEEVGAANFFGITHDNAFIT
CCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCEEEEECCCEEEC
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIAH
CCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
NNKSYFFETPGHITKQLYDLLLSIQQGEQKAPKDWIFEVG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECC
>Mature Secondary Structure 
ANLENLDWKNLGFSYIKTDFRFIATYKNGSWSHGELVSENVLQLSEGSPVLHYGQACFE
CCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
GLKAYRSQKGKALLFRPLENAKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKGGIEKRGARFITTAFDRAAP
CCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHCCHHHCCCEEEEHHHHHCCC
KGTGGVKVGGNYAASLLAHKMAVEQGYDDCIYLDPATHTKIEEVGAANFFGITHDNAFIT
CCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCEEEEECCCEEEC
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIAH
CCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
NNKSYFFETPGHITKQLYDLLLSIQQGEQKAPKDWIFEVG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]