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The map label for this gene is pcrA [H]

Identifier: 108563860

GI number: 108563860

Start: 1493023

End: 1495071

Strand: Direct

Name: pcrA [H]

Synonym: HPAG1_1435

Alternate gene names: 108563860

Gene position: 1493023-1495071 (Clockwise)

Preceding gene: 108563859

Following gene: 108563861

Centisome position: 93.53

GC content: 40.17

Gene sequence:

>2049_bases
ATGATGGATTTTGAAAAAAGCATTTTAGGCAATTTAAACGGGGTGCAAAAAATCGCTGCAAGCCATATTCAAGGGCCATT
GCTCATTTTAGCAGGAGCTGGGAGCGGCAAGACTAAGACTTTAACGAGCCGTTTAGCGTATTTGATTGGCGTTTGTGGCG
TGCCTAGCGAGAACACTTTAACGCTCACTTTCACCAATAAAGCGAGTAAAGAAATGCAAGAAAGGGCTTTGAAATTGTTG
AAAAACCAAACCCTTATCCCCCCCTTGCTTTGCACTTTCCATCGTTTTGGTTTGCTGTTTTTAAGGCAACACATGAGCCT
TTTAAAAAGAGCGTGCGATTTTTCGGTGCTAGATAGCGATGAAGTCAAAACGCTGTGCAAACAGCTCAAAATTTCAAACT
TTAGAGCCAGTATTTCTCAGATCAAAAACGGCATGATGGATTTGAGCATGCAAGATAGCGAATGCTATAAAGCGTATGAG
CTTTATCAAAACGCACTCAAAAAAGACAATTTAGTGGATTTTGACGATTTGCTTTTTTTAAGCCTTAAGATTTTACAAGA
TAATGAAACTATCGCCAAAGAGACTAGCGAGCACTACCATTACATTATGGTAGATGAGTATCAAGACACGAACGCCCTGC
AATTGGAGTTTTTAAAAAAATTGAGTTTCACGCACCATAATTTGTGCGTGGTGGGCGATGACGATCAGAGCATTTATGGG
TTTAGAGGGGCTGATATTTCTAACATTTTAAATTTTTCCAAGCATTTTAAAGGGGCTAAGGTGGTGAAATTAGAGACCAA
CTACCGCTCCAGCGCTGAAATTTTAGCATGCGCTAATTCTCTCATCAGCCACAACCAACACCGCCATGTTAAAACGCTTC
AAAGTTTTAAGGGATCGCATAAAAGCGTGATTTGTAAAGAATATTTGACGCAAAAAGAAGAGAGCCTGGATGTGGCTTAT
CAAATCAAAGCCCTTTTAAAGAAAGGCGAGAATTTAGAAAATATCGCTATTTTGTATCGCTTAAACGGGCTTAGCCGCAG
CATTGAAGAGAGCTTGAACGCTTTGAATATCCCTTATAGGCTCATTGGGGCGGTGAGTTTCTATGAAAGAGCCGAGGTTA
AAGACGCTTTGGCGTTCATGCATGTAGTGGCTAAAAAAGACGATCGCTTTTTTATTAAGCGCGTTTTAAACAAGCCCCCA
AGAGGTCTTGGCAAGATCACTCAAGAATGGATTTTTTCTCTTTTAGATGATGAGGGTTTGAATTTAGAAGAAGCGCTAAA
ACTTGGGGCGTTTAAAGACAAACTAAACCCTAAAAACGAATACGCTTTAAAGAAATTCATGGCCATGATAGGGCGTTTGA
GGGAGGCTTTTGAAATTTCAGTAGAGGAGTTTTGCGCTCGGTTTTTAGAAGAGACTAACCTTTTAAAAAGCTATGAAAAA
GAAGACAATTACGAAGAAAGAGAGGGCTTTGTTAAAGAGCTTTTAACCTTATTGAAAGAGCATTTTAAAACTAACCCCAC
GCATTCTTTGCTGGATTTTTTGAATGAAAGCGTGTTAGATGTCCATAATGCAGAAAACGCGCAAAAAGTGAGCTGCATGA
GCGTGCATATGAGTAAGGGATTAGAGTTTAAGCATGTGTTTGTGATCGGGTTAGAAGAAGGGTTTTTCCCGCATAGGGGG
TTCAATCAAGAAAGCGATTTAGAAGAAGAAAGGCGCTTGGCTTACGTAGCGATCACTAGGGCTAAAGAAGGATTGCAGCT
CTCTTATGTGAAAGAGCGTTCGTATTTTGGGAGGAAAATTTCTTGCTCGCCCTCTGTGTTTTTAGAAGAAGCCCAGTTGC
TCCAACAAGACAAACCCCCTAAACAGGATCATAAAAAAGATACGCCCATTAAAGTGGGGGATTTGATTAAGCATAAGATT
TTTGGCACCGGTAGGGTTTTAGGCGTAGAAAAAGGCTTGAGCGGTTTGTGTTTGAAAATCAATTGCGGAGGGAATGTCTA
TGATAAAATCTCAGCAAAATTTGTAGAAAAAGTGGATAACGGGTTTTGA

Upstream 100 bases:

>100_bases
TTAAAACCTCTGATTTTTCGTCGCCTTATTTTGATTTTGAAATTGATACTAACCTTTTAAAAGAGCGTTTAAACCAAGAA
GAAAAGGGCGAGTTTTTAGA

Downstream 100 bases:

>100_bases
AAATTTTAATCCTTTTTTTGATTTGTTTAAACGCGCTCTTCGCCCTAGATTTAAATACGCTTAAAACAGGGATTAAAGAA
ACTTACCTTAAAGAATACAA

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MMDFEKSILGNLNGVQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQTLIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSEHYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKVVKLETNYRSSAEILACANSLISHNQHRHVKTLQSFKGSHKSVICKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGAVSFYERAEVKDALAFMHVVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDDEGLNLEEALKLGAFKDKLNPKNEYALKKFMAMIGRLREAFEISVEEFCARFLEETNLLKSYEK
EDNYEEREGFVKELLTLLKEHFKTNPTHSLLDFLNESVLDVHNAENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEGLQLSYVKERSYFGRKISCSPSVFLEEAQLLQQDKPPKQDHKKDTPIKVGDLIKHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISAKFVEKVDNGF

Sequences:

>Translated_682_residues
MMDFEKSILGNLNGVQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQTLIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSEHYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKVVKLETNYRSSAEILACANSLISHNQHRHVKTLQSFKGSHKSVICKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGAVSFYERAEVKDALAFMHVVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDDEGLNLEEALKLGAFKDKLNPKNEYALKKFMAMIGRLREAFEISVEEFCARFLEETNLLKSYEK
EDNYEEREGFVKELLTLLKEHFKTNPTHSLLDFLNESVLDVHNAENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEGLQLSYVKERSYFGRKISCSPSVFLEEAQLLQQDKPPKQDHKKDTPIKVGDLIKHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISAKFVEKVDNGF
>Mature_682_residues
MMDFEKSILGNLNGVQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQTLIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSEHYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKVVKLETNYRSSAEILACANSLISHNQHRHVKTLQSFKGSHKSVICKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGAVSFYERAEVKDALAFMHVVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDDEGLNLEEALKLGAFKDKLNPKNEYALKKFMAMIGRLREAFEISVEEFCARFLEETNLLKSYEK
EDNYEEREGFVKELLTLLKEHFKTNPTHSLLDFLNESVLDVHNAENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEGLQLSYVKERSYFGRKISCSPSVFLEEAQLLQQDKPPKQDHKKDTPIKVGDLIKHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISAKFVEKVDNGF

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=688, Percent_Identity=32.8488372093023, Blast_Score=344, Evalue=1e-95,
Organism=Escherichia coli, GI48994965, Length=657, Percent_Identity=34.3987823439878, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1787196, Length=146, Percent_Identity=31.5068493150685, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322369, Length=464, Percent_Identity=29.0948275862069, Blast_Score=156, Evalue=1e-38,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77598; Mature: 77598

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDFEKSILGNLNGVQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTL
CCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
TLTFTNKASKEMQERALKLLKNQTLIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSD
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
EVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYELYQNALKKDNLVDFDDLLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLKILQDNETIAKETSEHYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
HHHHHCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEE
FRGADISNILNFSKHFKGAKVVKLETNYRSSAEILACANSLISHNQHRHVKTLQSFKGSH
ECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
KSVICKEYLTQKEESLDVAYQIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHH
LIGAVSFYERAEVKDALAFMHVVAKKDDRFFIKRVLNKPPRGLGKITQEWIFSLLDDEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
NLEEALKLGAFKDKLNPKNEYALKKFMAMIGRLREAFEISVEEFCARFLEETNLLKSYEK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNYEEREGFVKELLTLLKEHFKTNPTHSLLDFLNESVLDVHNAENAQKVSCMSVHMSKG
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
LEFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEGLQLSYVKERSYFGRKI
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHEEEECCCCCCEEEEEHHHHHCCCEE
SCSPSVFLEEAQLLQQDKPPKQDHKKDTPIKVGDLIKHKIFGTGRVLGVEKGLSGLCLKI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEE
NCGGNVYDKISAKFVEKVDNGF
ECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMDFEKSILGNLNGVQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTL
CCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
TLTFTNKASKEMQERALKLLKNQTLIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSD
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
EVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYELYQNALKKDNLVDFDDLLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLKILQDNETIAKETSEHYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
HHHHHCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEE
FRGADISNILNFSKHFKGAKVVKLETNYRSSAEILACANSLISHNQHRHVKTLQSFKGSH
ECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
KSVICKEYLTQKEESLDVAYQIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHH
LIGAVSFYERAEVKDALAFMHVVAKKDDRFFIKRVLNKPPRGLGKITQEWIFSLLDDEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
NLEEALKLGAFKDKLNPKNEYALKKFMAMIGRLREAFEISVEEFCARFLEETNLLKSYEK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNYEEREGFVKELLTLLKEHFKTNPTHSLLDFLNESVLDVHNAENAQKVSCMSVHMSKG
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
LEFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEGLQLSYVKERSYFGRKI
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHEEEECCCCCCEEEEEHHHHHCCCEE
SCSPSVFLEEAQLLQQDKPPKQDHKKDTPIKVGDLIKHKIFGTGRVLGVEKGLSGLCLKI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEE
NCGGNVYDKISAKFVEKVDNGF
ECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA