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The map label for this gene is pth [H]

Identifier: 108563841

GI number: 108563841

Start: 1474065

End: 1474625

Strand: Reverse

Name: pth [H]

Synonym: HPAG1_1416

Alternate gene names: 108563841

Gene position: 1474625-1474065 (Counterclockwise)

Preceding gene: 108563842

Following gene: 108563840

Centisome position: 92.37

GC content: 37.61

Gene sequence:

>561_bases
ATGACGCTTTTAGTAGGTTTAGGCAACCCTACTTTGCGTTACGCTCACACCAGACACAACGCTGGTTTTGATATTTTAGA
TTCACTCGTTAGCGAATTGGATCTTTCTTTCACTTTTTCTCCCAAACACAACGCTTGTTTGTGCGTTTATAAGGATTTTA
TCTTACTTAAGCCCCAAACTTACATGAATTTGAGCGGCGAGAGCGTTTTAAGCACTAAAAATTTTTACAAACCCAAAGAG
CTTTTAATTGTCCATGACGACTTGGATTTACCTTTGGGCGTTGTGAGGTTTAAAAATGGTGGGGGGAATGGGGGGCATAA
TGGCTTAAAGTCCATTGATTTATTGTGTTCAAATTCTTATTACCGCTTGAGAGTGGGGATTTCTAAAGGGATTGGCGTGA
TTGAGCATGTGCTTTCAAAATTCCACAAAAACGAAGAGCCTTTAAAAAACGCTGTGTTTGAACATGCCAAAAACGCCTTA
AAATTTTTTATAGAAAGCCATGATTTTAACGCCATGCAAAATCGTTTCACGCTTAAAAAACCTTTAAAAATAGAAAGTTA
A

Upstream 100 bases:

>100_bases
TATTTTGGTGCGCGATTTAGAAAAACACGAAAATGTTAAGATTTTAGATCATGATTCTATCGCTGTGATCGGTGTGATTA
AAGCGAAGTGATTTTAGGCT

Downstream 100 bases:

>100_bases
ATGCGCTCTATCAAAAATTTTAAGTTTTTATCGTGGTTTGAATAAGGGTTTAAAGTGCGTTTGTTTAGATTTGTGGGGTG
GTATTATTTCAAATACTTTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNACLCVYKDFILLKPQTYMNLSGESVLSTKNFYKPKE
LLIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGIGVIEHVLSKFHKNEEPLKNAVFEHAKNAL
KFFIESHDFNAMQNRFTLKKPLKIES

Sequences:

>Translated_186_residues
MTLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNACLCVYKDFILLKPQTYMNLSGESVLSTKNFYKPKE
LLIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGIGVIEHVLSKFHKNEEPLKNAVFEHAKNAL
KFFIESHDFNAMQNRFTLKKPLKIES
>Mature_185_residues
TLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNACLCVYKDFILLKPQTYMNLSGESVLSTKNFYKPKEL
LIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSYYRLRVGISKGIGVIEHVLSKFHKNEEPLKNAVFEHAKNALK
FFIESHDFNAMQNRFTLKKPLKIES

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=35.7142857142857, Blast_Score=85, Evalue=3e-17,
Organism=Escherichia coli, GI1787455, Length=174, Percent_Identity=38.5057471264368, Blast_Score=83, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321983, Length=142, Percent_Identity=35.9154929577465, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20935; Mature: 20804

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNACLCVYKDFILLKPQT
CEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEECEEEECCCH
YMNLSGESVLSTKNFYKPKELLIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSY
HCCCCCCCEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHEEHEECCCE
YRLRVGISKGIGVIEHVLSKFHKNEEPLKNAVFEHAKNALKFFIESHDFNAMQNRFTLKK
EEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEECCC
PLKIES
CCCCCC
>Mature Secondary Structure 
TLLVGLGNPTLRYAHTRHNAGFDILDSLVSELDLSFTFSPKHNACLCVYKDFILLKPQT
EEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEECEEEECCCH
YMNLSGESVLSTKNFYKPKELLIVHDDLDLPLGVVRFKNGGGNGGHNGLKSIDLLCSNSY
HCCCCCCCEECCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHEEHEECCCE
YRLRVGISKGIGVIEHVLSKFHKNEEPLKNAVFEHAKNALKFFIESHDFNAMQNRFTLKK
EEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEECCC
PLKIES
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA