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The map label for this gene is copA [H]

Identifier: 108563834

GI number: 108563834

Start: 1465178

End: 1467544

Strand: Direct

Name: copA [H]

Synonym: HPAG1_1409

Alternate gene names: 108563834

Gene position: 1465178-1467544 (Clockwise)

Preceding gene: 108563833

Following gene: 108563836

Centisome position: 91.78

GC content: 39.8

Gene sequence:

>2367_bases
ATGAAATGTTCGCATTGCCAGTTGGAGTTTAAAGAAAGTGAGCTTTTTAAAGAAGTGATCCATCATAAAGAATTGTATTT
TTGCTGTGCAGGGTGCGCTAGGGTGTATGCGTTATTACTAGATTTGAATTTAGAGAGCTTTTATGACAAATTAAACGATT
CCACTTTAGCCCCCGTAACGCCCCAAGATTCAATGAACGCTTTGGAATTAGAACAGGCCCTTGAAGAAAACAATAAGGGC
GATTTTATCCTTAATCTTTTGCTAGAAAAAACGCATTGCAACGCTTGCTTGTGGCTCAATCAAAAGGTTTTAGAGCGCTT
AAAGGGGGTTAAAAAAGTGAGCGTGAATTTCACCACCCACCATTTACAAATCGTGTTTGACAAATCTTTAAACCCTAAAG
AGATCGTTCAAAAAATTGAGAGTTTGGGTTATGGGGCTAAAATTTATAACGCAAAAAATTACGCCCTAAAAGCCCAAAAA
GAGCAGCGCTCCTATTTGCTCACTTTAAGCGTGGGGTTTTTTGCCACCATGAATTTGATGTTTATTGCAATTGCCAAGTA
TGCAAGTTATGGTGGCGCGAGTTATGGCGGTGCGAATTATGGCATTGGCATGGATAAGCTCATGCAAAGGAATTTGGATC
TCGTATCGCTCTTTTTAAGTTTGTTGGTGTTAGTGGTTGTGGGGCGTTTTTTCATTAAGGGGGCGTTTTACGGGCTAAAA
AATGGCGTTTTAGGCATGGATTTGAGCGTGTCTTTTGGAGCGTTATCGGCGTTTGTTTATTCCGTTTATGCCATGTTGGT
GTCCCAAGAGACTTATTTTGAAGCGAGCAGCACGATTTTAACGCTTGTTTTTGGCTCTAAGTTTTTGGAATTAAAGGCCA
GGCTGTTTGCGAATGAAAAATGTCTGGCCCTAGAATCGCATGAAATCCATAGCGTGATCGTTGTAGAAAATGGCAAACAG
ATAGAAAAACACCCTAAAGATGTGGCGATAGGCTCTGTTGTTTGGGTGCCAAGTGGGGCTAAAATCGCTTTAGATGGTGC
GCTTTTAAATAACGCGAGCGTGGATGCGTCTTTGATCAGTGGGGAGTTTAAGCCTTTGGAATTGGGGGTTAATGATCCAA
TTTTAGGGGGTTATGTGAATGTGGGCGTGCCTTTTAGCTATCAAGTGAGCGCTACTTTTCAAAACTCACGCCTTTCTGGT
TTGTTAGAAACTTTAAAAAAGAGTTTTTTAGAAAAGCCTTTAATTGAGAGCAGCGCGAATAAAATTGCGGATATTTTTTC
TAAAGCGGTGCTGTTTTTAGCCTTGGTAAGCTTTTTATTGTGGCAATTTGGTTTGGGGGGTGATTTTGAAAAAGCCTTAA
TGGTGTGCATTAGCGTGTTAGTCATCAGCTGCCCTTGCGCATTCGCTCTAGCTACACCCATTGCGTTAGTGATAGGGGTG
TTTAAAAACCCTTTGATCGTGTTTAAAGAAGCGTTGTTTTTAGAAACTCTGGCTAAAGTGGAAAAAATCTTTATAGACAA
AACCGGCACGCTCACGCAAAAAGAAGTCCTTTTAAAAGAAAAAATCATTTATGAAGAATTTGATGGAAGGCTTTTAAAGA
GCCTTTTAAAAACCAGAGAGCATTTAGCCCATAATGCGATTCTTAAAACTCTAGATAGCGATGAGGTTCATTTAGAAACG
ATAGAGTTTTTCGCTCATGGCCTGAAAGCGAGCTATCAAAACGAAACTTTGCTAGTGGGGAGCTTGAAATTTTTAAACGC
TATGGGGGTTAATATAAAGGCTAAAGAGAGCGCTAATATCATGGTAGGCTTTGCAAAAAATAAGACCTTATGCGCGTTAT
TCATTTTAGAAGAGCGTTTGAAAGCTAACGCTAAAGAAGTCGTTCAGGCTTTACAAAATAAAGGCTTAGAATTAGAAATT
TTAAGCGGGGATAATGAAAGCTCGGTTAAGGAGTGCGCGAAAAAATTAGGGATTTCTAAATATCATGCCCATTTGACCCC
TGAAGATAAGGCTCAAACCATCAGCTCTTATAAGGGCGTTTGCGCGATGGTAGGCGATGGCAATAATGACGCGCTAGCCT
TAAAACAAGCGAGCGTTTCTTTAGGGTTTGAAAAAAGCGCTTTGAGTAAAAGCACATGCGATATTTTGCTTTTAGAAGAG
GATTTGAGTTTGCTAAAAAAAGCGTTTGATAACGCTCAAAAAGTCTATCAAGTGGTGTTGCAAAACATTGTTTTGAGCTT
GATTTATAACGCTATTTTAATCCCGGTCGCTATGCTAGGATACATTAACCCTTTAATAGCGAGTTTGAGCATGAGTGCTA
GCTCGCTCTTAGTGGTCTTAAATTCTTTGAGATTGAAACGCTCTTAA

Upstream 100 bases:

>100_bases
AAGCGACAACACCAAAGAAGTTTTAAGCATCTATCAAATTTGTAACACTTATTCTATCAAAGCGCTTCTCAATTAGCGCC
CTTAAATTAAGGATTCAAAA

Downstream 100 bases:

>100_bases
ACAAACCACATCGTTTTGGCTAAAATGGCAATTAAAAAACCAAAAGTTAGAGCGATAGGGTGGATATATTTACCAATAGG
GTTTTTCTTGCCCAAAAACT

Product: putative cation transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MKCSHCQLEFKESELFKEVIHHKELYFCCAGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMNALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGIGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
IEKHPKDVAIGSVVWVPSGAKIALDGALLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSG
LLETLKKSFLEKPLIESSANKIADIFSKAVLFLALVSFLLWQFGLGGDFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVEKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKTREHLAHNAILKTLDSDEVHLET
IEFFAHGLKASYQNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISKYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSTCDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Sequences:

>Translated_788_residues
MKCSHCQLEFKESELFKEVIHHKELYFCCAGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMNALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGIGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
IEKHPKDVAIGSVVWVPSGAKIALDGALLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSG
LLETLKKSFLEKPLIESSANKIADIFSKAVLFLALVSFLLWQFGLGGDFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVEKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKTREHLAHNAILKTLDSDEVHLET
IEFFAHGLKASYQNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISKYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSTCDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
>Mature_788_residues
MKCSHCQLEFKESELFKEVIHHKELYFCCAGCARVYALLLDLNLESFYDKLNDSTLAPVTPQDSMNALELEQALEENNKG
DFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGGASYGGANYGIGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQ
IEKHPKDVAIGSVVWVPSGAKIALDGALLNNASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSG
LLETLKKSFLEKPLIESSANKIADIFSKAVLFLALVSFLLWQFGLGGDFEKALMVCISVLVISCPCAFALATPIALVIGV
FKNPLIVFKEALFLETLAKVEKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKTREHLAHNAILKTLDSDEVHLET
IEFFAHGLKASYQNETLLVGSLKFLNAMGVNIKAKESANIMVGFAKNKTLCALFILEERLKANAKEVVQALQNKGLELEI
LSGDNESSVKECAKKLGISKYHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSTCDILLLEE
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=872, Percent_Identity=22.5917431192661, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI115529486, Length=557, Percent_Identity=22.9802513464991, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI55743073, Length=495, Percent_Identity=24.040404040404, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1786691, Length=842, Percent_Identity=26.2470308788599, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1789879, Length=714, Percent_Identity=23.5294117647059, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786914, Length=438, Percent_Identity=24.2009132420091, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=440, Percent_Identity=25, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319772, Length=628, Percent_Identity=28.343949044586, Blast_Score=193, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320475, Length=643, Percent_Identity=25.3499222395023, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221329854, Length=486, Percent_Identity=23.4567901234568, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86696; Mature: 86696

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSHCQLEFKESELFKEVIHHKELYFCCAGCARVYALLLDLNLESFYDKLNDSTLAPVT
CCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMNALELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTH
CCCCCHHHHHHHHHHCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGGASYGGANYGIGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEEHHHHHHHHHHHHHHCCCC
CLALESHEIHSVIVVENGKQIEKHPKDVAIGSVVWVPSGAKIALDGALLNNASVDASLIS
EEEEECCCCEEEEEEECCCHHHHCCCCEEECEEEEECCCCEEEECCEEECCCCCCHHHHC
GEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSGLLETLKKSFLEKPLIESSAN
CCCCEEEECCCCCCCCCEEEECCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHH
KIADIFSKAVLFLALVSFLLWQFGLGGDFEKALMVCISVLVISCPCAFALATPIALVIGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FKNPLIVFKEALFLETLAKVEKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKTRE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HLAHNAILKTLDSDEVHLETIEFFAHGLKASYQNETLLVGSLKFLNAMGVNIKAKESANI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCEEECCCCCE
MVGFAKNKTLCALFILEERLKANAKEVVQALQNKGLELEILSGDNESSVKECAKKLGISK
EEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCH
YHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSTCDILLLEE
HCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCEEEEEHH
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NSLRLKRS
HHHHHCCC
>Mature Secondary Structure
MKCSHCQLEFKESELFKEVIHHKELYFCCAGCARVYALLLDLNLESFYDKLNDSTLAPVT
CCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
PQDSMNALELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTH
CCCCCHHHHHHHHHHCCCCCCEEHHHHHHHCCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFDKSLNPKEIVQKIESLGYGAKIYNAKNYALKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGGASYGGANYGIGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLK
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGVLGMDLSVSFGALSAFVYSVYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEK
CCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEEEHHHHHHHHHHHHHHCCCC
CLALESHEIHSVIVVENGKQIEKHPKDVAIGSVVWVPSGAKIALDGALLNNASVDASLIS
EEEEECCCCEEEEEEECCCHHHHCCCCEEECEEEEECCCCEEEECCEEECCCCCCHHHHC
GEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSGLLETLKKSFLEKPLIESSAN
CCCCEEEECCCCCCCCCEEEECCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHH
KIADIFSKAVLFLALVSFLLWQFGLGGDFEKALMVCISVLVISCPCAFALATPIALVIGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FKNPLIVFKEALFLETLAKVEKIFIDKTGTLTQKEVLLKEKIIYEEFDGRLLKSLLKTRE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
HLAHNAILKTLDSDEVHLETIEFFAHGLKASYQNETLLVGSLKFLNAMGVNIKAKESANI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCEEECCCCCE
MVGFAKNKTLCALFILEERLKANAKEVVQALQNKGLELEILSGDNESSVKECAKKLGISK
EEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCH
YHAHLTPEDKAQTISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSTCDILLLEE
HCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCEEEEEHH
DLSLLKKAFDNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
NSLRLKRS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA