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The map label for this gene is trpE [H]

Identifier: 108563655

GI number: 108563655

Start: 1291907

End: 1293409

Strand: Direct

Name: trpE [H]

Synonym: HPAG1_1230

Alternate gene names: 108563655

Gene position: 1291907-1293409 (Clockwise)

Preceding gene: 108563654

Following gene: 108563656

Centisome position: 80.93

GC content: 40.79

Gene sequence:

>1503_bases
ATGGTTAGTCTCATAGAAAAAGCCCCTTACATTCCCTACCCCCTAGCTCTTTATGAAAAATTAGAGTGCGAGCACACTTT
GCTTTTTGAAAGCGCTGAGATTGAGAGCAAAGCGCACACCAAATCCCTTTTAATGGCTAAAGCCTGTTTGAAGCTCATTT
GCAACCACAATATCGTAACTATCACTAGCCTGACGCCTAATGGTGGGGCGTTTTTGCAAAAATTGAGCGCGTTTTTTAAA
ACGCCTATACAAGACAATGCCCTAATTTTAACCTACACCAAAAATAGAAAAACGCAAGATGAGTTTTTAAAGCTCTTTGA
GCCTAGCCCTTTTGACGCTTTAAGGGGGCTTTTTAAAAGCGTTAAAACAAAACCCAAACACCCCTTTACGCTTTTAAGCG
CAGGCGTTTTTTCTTTTGAAATGCTCAATTTTTTTGAAGACTTGCCCCACTTAAAAGCAAAAGACAACACAGCGCATGAC
TTTATTTTTTTTGTCGCGCAAAATTTGATCATCATAGATCATAAAGAAAAAAGCGCTGAAATCTTGGGGGCGTGTTTTGA
TGAACGCTTTAAAACAGAGATAGCCCAGGAATTACAGGATTTAAAAGAGTTGGCTAAAAACATTAAAAGCGATTTTATCC
CTAAAAAAGCTAAGCAAAGTAAAGAAGTTAGCGTTAGTTGCGATGATAGCGAGTTTGAAAAAAGGGTGCTGTCCTTACAA
GAAGAAATCAAAAAGGGCGAGATTTTTCAAGCGGTGTTGTCGCGCAGCTTTTATATGGAGTGCTTGGAGGGTTTGAGTGC
GTATTATCATTTAAAACTAACTAACCCTAGCCCTTATATGTTCTATATTAAAGACAGCGATTTTATCCTTTTTGGGGCAA
GCCCTGAGAGCGCTTTAAAATACAACGCCTTAACGAATACGGCTGAAATTTATCCCATTGCTGGCACTCGTTTAAGAGGT
AAGGACAAACAAGGGAATATTGATTACGATTTGGATAGTAAAATGGAATTTGATTTGCAACACGACTATAAAGAAAGGGC
TGAACACATCATGCTAGTGGATTTAGCCAGAAACGACATGGCCAGAGTTTCAAAAAAGCGCTATTGCGACAAGCTTTTAA
AGGTGGATAAATATTCCAATGTCATGCATTTAGTTTCAAGGGTTGTGGGGGAATTGAAAAAAGGGTGCGATAGTTTGCAT
GCTTACAGGAGTTTTATGAACGCCGGCACGCTTAGCGGGGCGCCTAAAATCTCTGCGATCAGGCTCATTTACCAATTAGA
AAAGCAAAGGAGAGGCTCTTATGGGGGGAGTGTGGGGTATTTAAACAGCGAGGGTTCTATGGATTCTTGCATCACCATCC
GTTCATGTTTTGTCAAAAACAATAGAGCGGTGATCCAAGCAGGAGCCGGTATCGTGTTAGACAGCGTGCCGCAAAACGAA
GCGAATGAAACGAGAGCCAAAGCGCAAGCCCTTATTGATGCGATCAGGAAAACAAGCTTATGA

Upstream 100 bases:

>100_bases
AAGTTAGATTAGCCCTTGCAAGCTCTATAAGGCTATTAATTTATTTCCTATTTATCTATTTCTTGTAGAATACGAGTTTA
TTTTTAGCGTAAAGAAATTG

Downstream 100 bases:

>100_bases
AAATCTTTTTTATAGATAATTTTGATTCTTTCTCTTATAATTTGGTGTATGAATTAGAGTGTTTGGGTTATGAAGTGGCC
GTTTATCAAAACGATATTGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVSLIEKAPYIPYPLALYEKLECEHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFK
TPIQDNALILTYTKNRKTQDEFLKLFEPSPFDALRGLFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAQELQDLKELAKNIKSDFIPKKAKQSKEVSVSCDDSEFEKRVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNTAEIYPIAGTRLRG
KDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIRLIYQLEKQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNE
ANETRAKAQALIDAIRKTSL

Sequences:

>Translated_500_residues
MVSLIEKAPYIPYPLALYEKLECEHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFK
TPIQDNALILTYTKNRKTQDEFLKLFEPSPFDALRGLFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAQELQDLKELAKNIKSDFIPKKAKQSKEVSVSCDDSEFEKRVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNTAEIYPIAGTRLRG
KDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIRLIYQLEKQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNE
ANETRAKAQALIDAIRKTSL
>Mature_500_residues
MVSLIEKAPYIPYPLALYEKLECEHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVTITSLTPNGGAFLQKLSAFFK
TPIQDNALILTYTKNRKTQDEFLKLFEPSPFDALRGLFKSVKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAQELQDLKELAKNIKSDFIPKKAKQSKEVSVSCDDSEFEKRVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNTAEIYPIAGTRLRG
KDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIRLIYQLEKQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNE
ANETRAKAQALIDAIRKTSL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=498, Percent_Identity=45.9839357429719, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788114, Length=397, Percent_Identity=27.455919395466, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786809, Length=220, Percent_Identity=27.7272727272727, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=281, Percent_Identity=42.7046263345196, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324361, Length=374, Percent_Identity=23.5294117647059, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56532; Mature: 56532

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLIEKAPYIPYPLALYEKLECEHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVT
CCCCHHCCCCCCCCHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITSLTPNGGAFLQKLSAFFKTPIQDNALILTYTKNRKTQDEFLKLFEPSPFDALRGLFKS
EEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHH
VKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHDFIFFVAQNLIIIDHKEKSAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHH
ILGACFDERFKTEIAQELQDLKELAKNIKSDFIPKKAKQSKEVSVSCDDSEFEKRVLSLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCHHHHHHHHHHH
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHE
YNALTNTAEIYPIAGTRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDM
ECCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHHHHHCCEEEEEEHHHHHH
ARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RLIYQLEKQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNE
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCC
ANETRAKAQALIDAIRKTSL
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSLIEKAPYIPYPLALYEKLECEHTLLFESAEIESKAHTKSLLMAKACLKLICNHNIVT
CCCCHHCCCCCCCCHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITSLTPNGGAFLQKLSAFFKTPIQDNALILTYTKNRKTQDEFLKLFEPSPFDALRGLFKS
EEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHH
VKTKPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHDFIFFVAQNLIIIDHKEKSAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHH
ILGACFDERFKTEIAQELQDLKELAKNIKSDFIPKKAKQSKEVSVSCDDSEFEKRVLSLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCHHHHHHHHHHH
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHE
YNALTNTAEIYPIAGTRLRGKDKQGNIDYDLDSKMEFDLQHDYKERAEHIMLVDLARNDM
ECCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCEECCHHHHHHHHCCEEEEEEHHHHHH
ARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RLIYQLEKQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNRAVIQAGAGIVLDSVPQNE
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCC
ANETRAKAQALIDAIRKTSL
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]