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The map label for this gene is algC [H]

Identifier: 108563644

GI number: 108563644

Start: 1282789

End: 1284168

Strand: Direct

Name: algC [H]

Synonym: HPAG1_1219

Alternate gene names: 108563644

Gene position: 1282789-1284168 (Clockwise)

Preceding gene: 108563643

Following gene: 108563645

Centisome position: 80.36

GC content: 41.52

Gene sequence:

>1380_bases
ATGGACATTAGCATTTTTAGAGAATACGATATTAGAGGCATTTACCCCACCACTTTAGACGAAAAGAGTGCCTTTAGTAT
CGGCGTGGAGTTGGGGAAAATCATGCGAGAATGCGATAAAAGCGTGTTTGTAGGGCATGACGCCAGGGTGCATGGGCGCT
TTTTGTTTGAAGCTTTGAGCGCGGGGCTGCAATCAAGCGGCTTGAAAGTGTATGATTTAGGGCTAATCCCCACACCGGTA
GCGTATTTTGCAGCCTTTAATGAAATAGACAATATCCAATGCCCTAATTCTATTATGATCACTGGCTCTCACAACCCCAA
AGAATACAACGGCTTTAAAATCACGCTCAATCAAAATCCGTTTTATGGCAAGGACATTCAAGCTTTAAAAGACACGCTTT
TAAACGCCAAGCATGAAATAAAACCCCTAAAAGAAACACCAGAGAAAGTCAATGCCCTAGAAGCCTATCAGCGCTATTTG
ATCAAGGATTTTAAGCATTTGAAAAACCTTAAATACAAAATCGCCCTGGATTTTGGTAATGGCGTGGGAGCGTTAGGATT
AGAACCTATTTTAAAGGCTTTAAACATTGATTTTAGCAGCCTTTATAGCGATCCTGATGGGAATTTCCCTAACCACCACC
CAGACCCTAGCGAAGCGAAAAACTTAAAAGATTTAGAAAAACACATGCAAGAAAACGCTATTTCTATAGGCTTTGCTTTT
GATGGCGATGCGGACAGGATTGCGATGTTAAGCTCTCATCATGTTTATGCGGGCGATGAATTAGCGATTTTATTCGCTAA
ACGCTTGCATGCTCAAGGCATCACCCCCTTTGTGATCGGCGAAGTCAAATGCTCTCAAGTGATGTATAACACGATTAATA
CCTTTGGTAAGACGCTCATGTATAAAACCGGGCACAGCAATTTAAAAATCAAACTCAAAGAAACCCATGCGCATTTTGCG
GCTGAAATGAGCGGGCATATCTTTTTTAAAGAGCGCTATTTTGGCTATGATGACGCTCTTTATGCATGCTTAAGGGCTTT
AGAATTATTGCTCGAACAAACCCCAAGCGATTTGGAAAACACCATTAAAAACCTCCCCTATTCCTACACTACGCCTGAAG
AAAAAATCGCCGTGAGCGAAGAAGAAAAATTTGAAATCATTCATAACCTGCAAGAAACGCTTAAAAACCCGCCAAGCCAT
TTCCCTAAAATCAAAGAAATCATCAGCATTGATGGCGTGAGAGTGGTTTTTGAACATGGCTTTGGGCTTATTCGTGCAAG
CAACACCACCCCCTATTTAGTCAGCCGCTTTGAAGGCAAGGATGAAACAACGGCGTTAGAATATAAAAGGGCGTTGCTTG
GGTTATTAGAAAAACTTTAA

Upstream 100 bases:

>100_bases
TTAGAAAAATGCGTTCAGTTAAAACAAAAAGATCAAACAAACGCATGGCAAAATTTATGCGAACAGGGTTTAAATTTATT
CAAAAACAAGGAGTCATGAC

Downstream 100 bases:

>100_bases
AATAGAGCTTGGGATAATCTCATTTCATATCCCTTGCTCTTAAAGATATTAGATCAATTAAACAAGTTGCTTTTTAAAAC
CACATATAAAATCATAAGAT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRECDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKDIQALKDTLLNAKHEIKPLKETPEKVNALEAYQRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIDFSSLYSDPDGNFPNHHPDPSEAKNLKDLEKHMQENAISIGFAF
DGDADRIAMLSSHHVYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNTINTFGKTLMYKTGHSNLKIKLKETHAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQTPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQETLKNPPSH
FPKIKEIISIDGVRVVFEHGFGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL

Sequences:

>Translated_459_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRECDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKDIQALKDTLLNAKHEIKPLKETPEKVNALEAYQRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIDFSSLYSDPDGNFPNHHPDPSEAKNLKDLEKHMQENAISIGFAF
DGDADRIAMLSSHHVYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNTINTFGKTLMYKTGHSNLKIKLKETHAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQTPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQETLKNPPSH
FPKIKEIISIDGVRVVFEHGFGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL
>Mature_459_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRECDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKDIQALKDTLLNAKHEIKPLKETPEKVNALEAYQRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIDFSSLYSDPDGNFPNHHPDPSEAKNLKDLEKHMQENAISIGFAF
DGDADRIAMLSSHHVYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNTINTFGKTLMYKTGHSNLKIKLKETHAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQTPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQETLKNPPSH
FPKIKEIISIDGVRVVFEHGFGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=482, Percent_Identity=26.9709543568465, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51791; Mature: 51791

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRECDKSVFVGHDARVHGRFLFEALS
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
AGLQSSGLKVYDLGLIPTPVAYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNP
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
FYGKDIQALKDTLLNAKHEIKPLKETPEKVNALEAYQRYLIKDFKHLKNLKYKIALDFGN
CCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
GVGALGLEPILKALNIDFSSLYSDPDGNFPNHHPDPSEAKNLKDLEKHMQENAISIGFAF
CCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEE
DGDADRIAMLSSHHVYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNTINTFGKTLM
CCCCCCEEEEECCCEECCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHEE
YKTGHSNLKIKLKETHAHFAAEMSGHIFFKERYFGYDDALYACLRALELLLEQTPSDLEN
EECCCCCEEEEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHH
TIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQETLKNPPSHFPKIKEIISIDGVRVVFEHG
HHHHCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCC
FGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL
CEEEEECCCCCEEHEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRECDKSVFVGHDARVHGRFLFEALS
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
AGLQSSGLKVYDLGLIPTPVAYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNP
HHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
FYGKDIQALKDTLLNAKHEIKPLKETPEKVNALEAYQRYLIKDFKHLKNLKYKIALDFGN
CCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
GVGALGLEPILKALNIDFSSLYSDPDGNFPNHHPDPSEAKNLKDLEKHMQENAISIGFAF
CCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEE
DGDADRIAMLSSHHVYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNTINTFGKTLM
CCCCCCEEEEECCCEECCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHEE
YKTGHSNLKIKLKETHAHFAAEMSGHIFFKERYFGYDDALYACLRALELLLEQTPSDLEN
EECCCCCEEEEEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHH
TIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQETLKNPPSHFPKIKEIISIDGVRVVFEHG
HHHHCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCC
FGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL
CEEEEECCCCCEEHEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]