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The map label for this gene is ggt [H]

Identifier: 108563481

GI number: 108563481

Start: 1113126

End: 1114829

Strand: Reverse

Name: ggt [H]

Synonym: HPAG1_1056

Alternate gene names: 108563481

Gene position: 1114829-1113126 (Counterclockwise)

Preceding gene: 108563482

Following gene: 108563480

Centisome position: 69.84

GC content: 43.54

Gene sequence:

>1704_bases
ATGAGACGGAGTTTTTTAAAGACGATTGGCTTGGGTGTGATAGCGCTCTCTTTGGGTTTGTTAAGCCCTTTGAGTGCAGC
GAGTTACCCGCCCATTAAAAACACTAAAGTAGGCTTAGCCCTTTCTAGCCACCCGCTAGCCACTGAAATCGGGCAAAAGG
TTTTAGAAGAAGGAGGTAATGCGATTGATGCGGCCGTAGCGATAGGTTTTGCTCTAGCGGTTGTCCATCCTGCAGCAGGC
AATATTGGTGGTGGGGGTTTTGCGGTTATCCATTTGGCTAATGGTGAAAATGTTGCATTAGATTTTAGAGAAAAAGCCCC
CTTAAAAGCCACTAAAAACATGTTTTTAGACAAGCAAGGCAATGTGGTCCCTAAACTCAGTGAAGATGGCTATTTGGCGG
CTGGGGTTCCTGGAACGGTGGCGGGCATGGAAGCGATGTTGAAAAAATACGGCACTAAAAAACTATCGCAACTCATTGAT
CCTGCCATTAAATTGGCTGAAAATGGTTATGCGATTTCACAAAGACAAGCAGAAACCCTAAAAGAAGCGAGGGAGCGGTT
TTTAAAATACAGTTCTAGCAAAAAGTATTTTTTTAAAAAAGGGCATCTTGATTATCAAGAAGGGGATTTGTTTGTCCAAA
AAGATTTAGCCAAGACTTTGAATCAAATCAAAACGCTAGGCGCTAAAGGTTTTTATCAAGGGCAAGTCGCTGAGCTTATT
GAGAAAGACATGAAAAAAAATGGAGGGATTATCACTAAAGAGGATTTAGCCAGTTACAATGTGAAATGGCGCAAACCCGT
GGTAGGGAGTTATCGTGGGTATAAGATCATTTCTATGTCGCCGCCAAGTTCAGGAGGCACGCATTTGATCCAGATTTTAA
ATGTCATGGAGAATGCGGATTTAAGCGCCCTTGGGTATGGGGCTTCTAAGAATATCCATATCGCTGCCGAAGCGATGCGC
CAAGCTTATGCGGACAGGTCGGTTTATATGGGAGATTCTGATTTTGTTTCGGTGCCGGTGGATAAATTGATTAATAAAGC
GTATGCCAAAAAGATTTTTGATACTATCCAGCCAGATACGGTTACGCCAAGCTCTCAAATCAAGCCAGGAATGGGGCAGT
TGCATGAGGGGAGCAACACCACGCATTATTCTGTAGCGGACAGGTGGGGGAATGCAGTCAGCGTTACTTACACCATTAAC
GCCTCTTATGGGAGCGCTGCTAGTATTGATGGGGCAGGATTTTTATTGAACAATGAAATGGATGATTTTTCCATAAAGCC
TGGGAATCCTAATCTCTATGGTTTAGTGGGGGGCGATGCGAATGCGATTGAAGCCAATAAGCGCCCTTTAAGCTCCATGT
CGCCTACGATCGTGTTGAAAAACAATAAGGTTTTCTTGGTGGTGGGAAGCCCTGGAGGGTCTAGGATTATCACTACGGTG
TTGCAAGTGATTTCTAATGTCATTGATTATAATATGAATATTTCTGAAGCGGTCTCAGCCCCTAGATTCCACATGCAATG
GCTCCCTGATGAATTAAGGATTGAAAAGTTTGGCATGCCTGCTGATGTGAAAGACAACCTCACTAAAATGGGCTATCAAA
TCGTTACTAAGCCGGTCATGGGTGATGTGAATGCGATCCAAGTTTTACCTAAAACTAAAGGGAGCGTTTTCTATGGATCA
ACGGATCCAAGGAAAGAATTTTAA

Upstream 100 bases:

>100_bases
GCGCTCAAACCATTAATAGCATCATGTAAGCTATAAGCGAGAGAGTGTTTTGTAAAGCTTATGTTATAATAACGATTATT
GTTGATTGAAAGGAAAACAG

Downstream 100 bases:

>100_bases
TTCTTTGTCATATGCGGGTTTTAATCCTATCTAGCCTTATTGTTTTGGGGAGGGGAGGGCTTTTTAGCGAGAAAATCTTA
AATTTAGTTTTAAAATTCAT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Sequences:

>Translated_567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF
>Mature_567_residues
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTIN
ASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=479, Percent_Identity=32.1503131524008, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI73915090, Length=479, Percent_Identity=32.1503131524008, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI73915096, Length=479, Percent_Identity=32.1503131524008, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI73915094, Length=479, Percent_Identity=32.1503131524008, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI113429324, Length=477, Percent_Identity=30.8176100628931, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=30.3534303534304, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI109148539, Length=473, Percent_Identity=29.1754756871036, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=25.3623188405797, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=25.9124087591241, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=24.6823956442831, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI30581157, Length=176, Percent_Identity=38.0681818181818, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI30581155, Length=176, Percent_Identity=38.0681818181818, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=52.8864059590317, Blast_Score=560, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI212646519, Length=511, Percent_Identity=34.6379647749511, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=34.8697394789579, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17506189, Length=609, Percent_Identity=30.8702791461412, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193208247, Length=551, Percent_Identity=33.2123411978221, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=551, Percent_Identity=33.2123411978221, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17542894, Length=493, Percent_Identity=32.4543610547667, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI72001495, Length=228, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17564448, Length=437, Percent_Identity=25.629290617849, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323330, Length=523, Percent_Identity=31.5487571701721, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161077496, Length=529, Percent_Identity=33.2703213610586, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI18859893, Length=555, Percent_Identity=31.3513513513514, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=29.7047970479705, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=29.7047970479705, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=29.7047970479705, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=29.7047970479705, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=29.7047970479705, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=27.8719397363465, Blast_Score=162, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61095; Mature: 61095

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGN
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRRSFLKTIGLGVIALSLGLLSPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGN
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
NVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETL
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
KEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIAAEAMRQAYADRSVYMGDSDFVSVPVDKLINKAYAKKIFDTIQPDT
CCEECCCCCCCEEHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCHHHHHHH
LQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIQVLPKTKGSVFYGSTDPRKEF
CCCCEEEEEECCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]