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The map label for this gene is hemH [H]

Identifier: 108563441

GI number: 108563441

Start: 1072366

End: 1073373

Strand: Reverse

Name: hemH [H]

Synonym: HPAG1_1016

Alternate gene names: 108563441

Gene position: 1073373-1072366 (Counterclockwise)

Preceding gene: 108563444

Following gene: 108563440

Centisome position: 67.24

GC content: 37.3

Gene sequence:

>1008_bases
ATGAATTTAATCAATGAAAAGCTTGATAATTTAGAAAATAACGCCACAAAATCCCCTAAAGAAGCGGTCGTTCTTTTGAA
TATGGGAGGGCCTAACAGCCTTTATGAAGTGGGGGTGTTTTTAAAAAACATGTTTGATGACCCCTTTATCCTTACCATTA
AAAATAATTTTATGCGTAAAATGGTGGGTAAAATGATTGTCAATAGCCGCATAGAAAAATCCAAAAAAATCTATGAAAAA
TTAGGGGGCAAATCCCCTTTAACGCCTATCACATTCGCCCTTACAGAGCGTTTGAATAAATTGGATCCTTCTCGCTTTTA
TACTTATGCGATGCGTTATACCCCCCCTTATGCATCTATGGTCTTGCAAGATTTAGCCTTAAAAGAAATAGAAAGCTTGG
TGTTTTTTTCCATGTATCCTCAATATTCTAGCACCACCACCCTTTCTAGTTTCAATGACGCTTTTAACGCCCTAAAATCC
CTAGAAACTTTCCGCCCTAAGGTGCGAGTCATAGAGCGCTTTTATGCTGACAAAAAGCTTAATGAAATCATTTTAAACAC
GATTTTAAACACCCTAAACAACCGCAAAAGCCAGGATTTTGTCCTAATCTTTTCCGTCCATGGCTTGCCTAAAAGCGTTA
TTGATGCCGGCGATACTTACCAGCAAGAATGCGAACACCATGTGAGCTTGTTAAAAGAGTTGATGCAACAAAAAAATATC
CCTTTTAAAGAAGTCTTACTCTCTTACCAATCCAAACTAGGGCCTATGAAATGGCTAGAGCCAAGCACTGAAGAATTGAT
AGAAAAGCACCGCAAATCTCATATTATTATCTACCCTTTAGCTTTCACGATTGATAATTCTGAAACGCTCTATGAATTAG
ACATGCAATACCGCTTGATGGCAGAGCGCTTGGCAATTAAAGAATATTTAGTTTGCCCATGCTTAAACGATTCCATAGAG
TTTGCAAAATTTATCATTGGATTAGTTAAAAACCTTAAAAGTGAGTGA

Upstream 100 bases:

>100_bases
AGAAGAATCTTGTGTATTTAATGCTTGCAAACTCATCTCTAACATTAACTTCTTTCTAACGATTTATTTTTTATTAATCG
TTTTATTTTAGCATGCCCTA

Downstream 100 bases:

>100_bases
AATTTGCATAAAAGAGCGATTATTATAGTAAAATACCAAGTTTTCAAATCTATTAAAAAATAAAGGTTATTTCATGTTTT
CACTCTCTTATGTTTCCAAG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNLINEKLDNLENNATKSPKEAVVLLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEIESLVFFSMYPQYSSTTTLSSFNDAFNALKS
LETFRPKVRVIERFYADKKLNEIILNTILNTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNI
PFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAIKEYLVCPCLNDSIE
FAKFIIGLVKNLKSE

Sequences:

>Translated_335_residues
MNLINEKLDNLENNATKSPKEAVVLLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEIESLVFFSMYPQYSSTTTLSSFNDAFNALKS
LETFRPKVRVIERFYADKKLNEIILNTILNTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNI
PFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAIKEYLVCPCLNDSIE
FAKFIIGLVKNLKSE
>Mature_335_residues
MNLINEKLDNLENNATKSPKEAVVLLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKIYEK
LGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEIESLVFFSMYPQYSSTTTLSSFNDAFNALKS
LETFRPKVRVIERFYADKKLNEIILNTILNTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNI
PFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLMAERLAIKEYLVCPCLNDSIE
FAKFIIGLVKNLKSE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=32.3353293413174, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=32.3353293413174, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=24.3827160493827, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324750, Length=341, Percent_Identity=30.4985337243402, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=28.9473684210526, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=28.8888888888889, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552018, Length=145, Percent_Identity=32.4137931034483, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38763; Mature: 38763

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLINEKLDNLENNATKSPKEAVVLLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRK
CCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHH
VLQDLALKEIESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYADKKL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEIILNTILNTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLM
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
AERLAIKEYLVCPCLNDSIEFAKFIIGLVKNLKSE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLINEKLDNLENNATKSPKEAVVLLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRK
CCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNKLDPSRFYTYAMRYTPPYASM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHH
VLQDLALKEIESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYADKKL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEIILNTILNTLNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNI
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQYRLM
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
AERLAIKEYLVCPCLNDSIEFAKFIIGLVKNLKSE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA