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The map label for this gene is acxA [H]

Identifier: 108563105

GI number: 108563105

Start: 712970

End: 715111

Strand: Direct

Name: acxA [H]

Synonym: HPAG1_0680

Alternate gene names: 108563105

Gene position: 712970-715111 (Clockwise)

Preceding gene: 108563104

Following gene: 108563106

Centisome position: 44.66

GC content: 45.33

Gene sequence:

>2142_bases
ATGAAAGACGCAAGAGTTCAGGTGATGGGTATTGATGCCGGTGGCACCATGACGGACACGTTTTTTGTGAAAGAAAATGG
CAGTTTCGTAGTCGGTAAAGCCCAAAGCAACCCAGAAGATGAGAGTTTAGCTATTTATAATAGCTCACAAGACGCTTTAT
CGCACTGGCAATCGGATGTGAGTAAAGTTTATCCAGAGTTGGTCACTTGCGTGTATTCAGGCACGGCGATGCTCAATCGG
GTCGTCCAAAGGCGCGGGATGGAAGTGGGCCTGATTTGCAATAAGGGTTTTGAGCAAATGCATTCTATGGGCAGAGCGTT
GCAATCCTACTTGGGGTATGCGCTAGAAGAAAGGTTGCATATCAACACGCACAAGTATGATGATCCGCTGATTCCTTTAA
AAAGGATTAGAGGCGTTACAGAAAGAACCGATGTCAAGGGGCAAGTGGTTATCCCAGTGCGTCAAGAAGAGGTTAAAATC
GCTGTTAAGGAGCTTTTAGAAGCGGGTGCAAAGGCCATTGTGATTTGCTTGTTGCAATCTCATAAAAACGCTGAAAGCGA
GCGGATCGTTAGAGATATTGCGTTAAAAGAGATTGAAAAATTGGGTAAAAATATTCCTGTATTCGCTTCTGTGGATTACT
ACCCTCAAAGAAAAGAAAGCCACAGAATGAACACCACTATCTTAGAAGCTTATGCGGCTGAGCCAAGCAGACAAACCCTC
TCTAAAGTCAGCAACCGATTCAAAGAGCATGGCGCTAAATTTGATCTTCGTGTGATGGCAACGCATGGAGGCACCATTAG
CTGGAAAGCTAAAGAGCTCGCTAGGACTATTGTGAGCGGCCCTATTGGAGGCGTGATTGGATCTAAATTGCTAGGCGAAA
CGCTTGGTTATGACAATATTGCATGCAGCGATATTGGCGGCACGAGCTTTGATATGGCGCTTATCGTTAAGAGCAATTTC
AACATCGCTTCTGACCCTGATATGGCGCGCCTTGTTTTATCTCTACCGCTTGTGGCTATGGATTCTGTTGGCGCTGGTGC
GGGGAGTTTTGTGCGCATTGATCCACACAGCCGATCTGTTAAACTAGGGCCTGACAGCGCGGGGTATAGAGTTGGCACTT
GTTGGAAGGACAGCGGGTTAGACACGGTTTCAGTAACCGATTGCCATATTGTTTTAGGCTATTTGAACCCGGATAATTTC
TTAGGCGGTTTGATCAAATTAGATGTGGATAGGGCTAAAAAACACATTAAAGAGCAAATCGCTGATCCGCTAGGCATTAG
CGTAGAAGATGCGGCTGCGGGTGTGATTGAGTTGCTTGATTTGGAGCTTAAAGAATACTTGCGATCCAACATTAGCGCTA
AAGGGTATAGCCCGTCTGATTTTGTGTGCTTTTCATATGGTGGCGCGGGGCCTGTGCATACTTATGGCTATACAGAAGGA
TTAGGGTTTAAGGATGTGGTAGTGCCTGCGTGGGCGGCTGGATTTAGTGCTTTTGGTTGCGCTTGCGCTGATTTTGAATA
CAGATACGATAAGAGCGTGGATATTGCCATTCCGCAGTATTCTTCAGACAAGTCAAAAATAGAGGCATGCAAGATCATTC
AAGACGCATGGGATGAATTGACCCTCAAAGTGATTGAAGAGTTCAAGATCAATGGATTTTCTCAAAAAGATGTGATCTTA
AGACCTGGATACAGGATGCAGTATATGGGGCAATTGAATGACTTAGAGATCACTTCTCCTGTATCAAAAGCTGCAAGCGT
GGCTGATTGGGAAGAGATTGTCAAAGAATATGAAAAAACCTACGCTCGCGTTTATTCTGAATCAGCGTGTTCTCCAGAGC
TTGGTTTTAGCGTGACCGGCGTGATCATGCGTGGTGTTGTGGCTACGCAAAAACCTGTGATTCCGGTTGAAAAAGAGCAT
GGCGCTACGCCCCCAAAAGAAGCCAAAATAGGCGTTAGAAAATTCTATCGGCATAAAAAATGGGTGGATGCAGATGTGTG
GCAAATGGAAAAATTACTGCCTGGAAATGAAGTCATAGGGCCTGCGATCGTGGAATCAGATGCGACCACTTTCGTGATAC
CCAAGGGCTTTGCGACAAGACTAGACAAACACCGATTGTTCCACTTGAAAGAAGTTAAATAA

Upstream 100 bases:

>100_bases
TTACAAACAACTTTGAAATAAACGATTCCCGTTTAAAAATCAGCCCTATACTTTGAATAGGTTGCCTCGAGCAACACTTT
AAACACAAGGAGTCTAAAAA

Downstream 100 bases:

>100_bases
AGGAGTTCAAAATGGCAAATTTATTGAAAAACGGCAAAACTTTAAAACAAGCTAGAGATGAAATCCTAGCCAGGACAGAA
AAAACAGGGCATTATAATGG

Product: hydantoin utilization protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MKDARVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWQSDVSKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRQEEVKI
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEVK

Sequences:

>Translated_713_residues
MKDARVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWQSDVSKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRQEEVKI
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEVK
>Mature_713_residues
MKDARVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWQSDVSKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRQEEVKI
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKIEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GATPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEVK

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=515, Percent_Identity=24.6601941747573, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133901900, Length=725, Percent_Identity=22.6206896551724, Blast_Score=98, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322634, Length=584, Percent_Identity=24.486301369863, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45550492, Length=735, Percent_Identity=25.578231292517, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 78548; Mature: 78548

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDARVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWQSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
SKVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRQEEVKIAVKELLEAGAKAIVICLLQS
ECCCCCCCCCCCHHHHCCCCHHCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVDRAKKHIKEQI
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCCEEEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKIEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGATPPKEAKIGVRKFYRHKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
WVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEVK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHEEEEECCC
>Mature Secondary Structure
MKDARVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWQSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
SKVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRQEEVKIAVKELLEAGAKAIVICLLQS
ECCCCCCCCCCCHHHHCCCCHHCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVDRAKKHIKEQI
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCCEEEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKIEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGATPPKEAKIGVRKFYRHKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
WVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEVK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]