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The map label for this gene is nrdA [H]

Identifier: 108563087

GI number: 108563087

Start: 692354

End: 694720

Strand: Reverse

Name: nrdA [H]

Synonym: HPAG1_0662

Alternate gene names: 108563087

Gene position: 694720-692354 (Counterclockwise)

Preceding gene: 108563088

Following gene: 108563086

Centisome position: 43.52

GC content: 40.6

Gene sequence:

>2367_bases
TTGATTACAGTGGTTAAACGAAACGGGCGCATTGAGCCTTTGGACATTACAAAAATCCAAAAATACACTAAGGACGCTAC
GGACAATTTAGAGGGCGTGAGCCAAAGTGAGCTGGAAGTGGATGCGAGGTTGCAATTCAGGGACAAGATCACTACTGAAG
AAATCCAACAAACTTTGATTAAAACCGCTGTGGATAAGATAGATATTGACACGCCTAATTGGAGCTTTGTCGCCTCAAGG
CTTTTTTTGTATGATTTATACCATAAAGTGAGTGGTTTTACAGGATATAGGCATTTGAAAGAGTATTTTGAAAACGCTGA
AGAAAAGGGTCGCATCCTTAAGGGCTTTAAGGAAAAATTTGATTTAGAGTTTTTAAATAGCCAGATCAAGCCTGAAAGGG
ATTTCCAATTCAATTATTTAGGGATTAAAACCTTGTATGATCGCTATTTGTTGAAAGACGCTAACAATAACCCTATTGAA
TTGCCCCAACACATGTTTATGAGCATTGCGATGTTTTTAGCGCAAAACGAACAAGAACCCAATAAAATCGCCTTAGAATT
TTATGAAGTTTTGAGCAAATTTGAAGCGATGTGCGCAACCCCCACTCTAGCGAACGCCCGCACCACCAAGCACCAGTTAA
GCTCATGCTATATTGGCAGCACGCCGGATAATATTGAGGGGATTTTTGACAGCTATAAGGAAATGGCGTTGTTGTCCAAA
TACGGCGGAGGGATTGGCTGGGATTTTTCTTTGGTGCGCTCTATTGGGAGTTATATTGATGGGCATAAAAATGCGAGCGC
TGGCACGATCCCGTTTTTAAAAATCGCTAACGATGTGGCGATTGCGGTGGATCAATTAGGCACACGAAAGGGTGCGATTG
CGGTGTATTTGGAAATTTGGCACATTGATGTGATGGAGTTCATTGATTTAAGGAAAAATAGCGGCGATGAAAGGCGAAGA
GCGCATGATTTATTCCCGGCTCTTTGGGTGTGCGATTTGTTTTTGAAAAGGGTTTTAGAAGACGCGATGTGGACTTTGTT
TGACCCTTATGAGTGTAAGGATTTGACTGAGCTTTATGGGCAGGATTTTGAAAAACGCTATTTAGAGTATGAAAAAGATC
CTAAAATCATTAAAGAATACATTAACGCTAAAGATTTATGGAAAAAAATCTTAATGAATTATTTTGAAGCCGGCTTGCCT
TTTTTGGCCTTTAAAGATAACGCCAATCGGTGCAACCCAAACGCTCATGCAGGAATCATTCGATCCAGCAATTTATGCAC
GGAGATTTTTCAAAATACCGCACCTAACCACTACTACATGCAAATAGAATACACCGATGGCGCCATAGATTTTTTTGAAG
AAAAAGAGTTGGTAACGACAGATAGTAATATCACTAAATGCGCTAACAAGCTCACTAGCACGGATATTCTAAAGGGTAAG
CCAATCTATATTGCTACTAAAGTCGCTAAAGATGGGCAAACGGCGGTGTGCAATCTGGCGAGCATCAATTTAAGCAAAAT
CAACACTGAAGAAGACATTAAAAGGGTTGTGCCGATCATGGTTAGGCTTTTAGACAATGTGATTGATTTGAATTTCTACC
CCAACCGCAAAGTCAAAGCCACCAATTTACAAAATAGGGCCATAGGGTTAGGGGTTATGGGTGAAGCGCAAATGCTCGCA
GAACATCAAATCGCTTGGGGGTCTAAAGAGCATTTAGAAAAAATTGACGCTTTAATGGAGCAAATCAGCTACCATGCGAT
TGACACGAGCGCGAATCTAGCGAAAGAAAAAGGGGTTTATAAGGATTTTGAAAATTCAGAATGGAGTAAGGGGATTTTCC
CCATTGATAAAGCCAATAATGAAGCCTTAAAGCTCACCGAAAAAGGGCTTTTCAATCACGCTTGCGATTGGCAAGGTTTG
AGAGAAAAAGTCAAGGCTAATGGCATGCGTAATGGCTATTTAATGGCGATCGCTCCCACAAGCTCCATTTCTATTTTAGT
AGGCACAACCCAAACGATTGAACCCATTTATAAGAAAAAATGGTTTGAAGAAAATTTGAGCGGGCTAATTCCTGTAGTAG
TGCCTAATTTGAATGTAGAAACCTGGAATTTTTACACATCAGCCTATGATATTGACGCTAAAGATTTGATTAAAGCAGCA
GCCGTGCGCCAAAAATGGATCGATCAAGGCCAAAGCATCAATGTGTTTTTACGCATAGAAAACGCCAGCGGTAAAACCTT
GCATGACATCTACACGCTCGCTTGGAAATTAGGGTTAAAATCCACTTATTATTTGCGCAGCGAAAGCCCTAGCATAGATG
AAAAAAGCGTGTTGGATCGATCGGTGGAGTGTTTTAATTGCCAATAA

Upstream 100 bases:

>100_bases
ATTAATAGAACAGATCCAACTTGAACTTTTCTTTTTCTTAAGTTTTTTATTGATACAATGCCAAATTTAAAAGAAAACGA
TTTGATTTAAAGGAAAAATT

Downstream 100 bases:

>100_bases
TATAAGCTTAAATAAGCTAATCTTTGCTAAAATGAGATTCAAAATGATTTAAGGAAGATGAATGCTTTTTGCGATGATTG
GTTCAGGGGGGTTTATCGCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGAIDFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSINVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ

Sequences:

>Translated_788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGAIDFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSINVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ
>Mature_788_residues
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLIKTAVDKIDIDTPNWSFVASR
LFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKFDLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIE
LPQHMFMSIAMFLAQNEQEPNKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIWHIDVMEFIDLRKNSGDERRR
AHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYGQDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLP
FLAFKDNANRCNPNAHAGIIRSSNLCTEIFQNTAPNHYYMQIEYTDGAIDFFEEKELVTTDSNITKCANKLTSTDILKGK
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKATNLQNRAIGLGVMGEAQMLA
EHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGL
REKVKANGMRNGYLMAIAPTSSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
AVRQKWIDQGQSINVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDRSVECFNCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=813, Percent_Identity=33.4563345633456, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI2367133, Length=805, Percent_Identity=26.7080745341615, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1789030, Length=671, Percent_Identity=29.5081967213115, Blast_Score=259, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17555242, Length=823, Percent_Identity=31.9562575941677, Blast_Score=377, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6320914, Length=830, Percent_Identity=33.0120481927711, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322123, Length=822, Percent_Identity=31.6301703163017, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17352481, Length=810, Percent_Identity=32.0987654320988, Blast_Score=351, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90117; Mature: 90117

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH
KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHH
DLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH
HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII
CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE
RSSNLCTEIFQNTAPNHYYMQIEYTDGAIDFFEEKELVTTDSNITKCANKLTSTDILKGK
ECCHHHHHHHHCCCCCEEEEEEEECCCCHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCC
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA
CEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT
CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC
SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCHHHHHHHH
AVRQKWIDQGQSINVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR
HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC
SVECFNCQ
CCHHCCCC
>Mature Secondary Structure
MITVVKRNGRIEPLDITKIQKYTKDATDNLEGVSQSELEVDARLQFRDKITTEEIQQTLI
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHH
KTAVDKIDIDTPNWSFVASRLFLYDLYHKVSGFTGYRHLKEYFENAEEKGRILKGFKEKF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHCCHHHHHHHHHH
DLEFLNSQIKPERDFQFNYLGIKTLYDRYLLKDANNNPIELPQHMFMSIAMFLAQNEQEP
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
NKIALEFYEVLSKFEAMCATPTLANARTTKHQLSSCYIGSTPDNIEGIFDSYKEMALLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
YGGGIGWDFSLVRSIGSYIDGHKNASAGTIPFLKIANDVAIAVDQLGTRKGAIAVYLEIW
HCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEEH
HIDVMEFIDLRKNSGDERRRAHDLFPALWVCDLFLKRVLEDAMWTLFDPYECKDLTELYG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
QDFEKRYLEYEKDPKIIKEYINAKDLWKKILMNYFEAGLPFLAFKDNANRCNPNAHAGII
CCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEE
RSSNLCTEIFQNTAPNHYYMQIEYTDGAIDFFEEKELVTTDSNITKCANKLTSTDILKGK
ECCHHHHHHHHCCCCCEEEEEEEECCCCHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCC
PIYIATKVAKDGQTAVCNLASINLSKINTEEDIKRVVPIMVRLLDNVIDLNFYPNRKVKA
CEEEEEEECCCCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
TNLQNRAIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVY
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
KDFENSEWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPT
CCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECC
SSISILVGTTQTIEPIYKKKWFEENLSGLIPVVVPNLNVETWNFYTSAYDIDAKDLIKAA
CCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEECCCHHHHHHHH
AVRQKWIDQGQSINVFLRIENASGKTLHDIYTLAWKLGLKSTYYLRSESPSIDEKSVLDR
HHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHC
SVECFNCQ
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]