Click here to switch to the map view.

The map label for this gene is gltX1 [H]

Identifier: 108563053

GI number: 108563053

Start: 653440

End: 654759

Strand: Direct

Name: gltX1 [H]

Synonym: HPAG1_0628

Alternate gene names: 108563053

Gene position: 653440-654759 (Clockwise)

Preceding gene: 108563052

Following gene: 108563054

Centisome position: 40.93

GC content: 37.65

Gene sequence:

>1320_bases
ATGCTTCGTTTTGCGCCTTCGCCTACAGGGGATATGCACATAGGGAATTTAAGGGCAGCCATTTTCAACTACATTGTGGC
CAAACAGCAACACAAACCCTTTCTCATTCGCATTGAAGACACGGACAAAGAGCGCAATATTGAAGGCAAAGACCAGGAAA
TTTTAGAGATTTTAAAGTTTATGGGGATAAGCTGGGACAAGCTCGTGTATCAAAGCCATAACATAGATTATCACAGAGAA
ATGGCAGAAAAATTACTGAAAGAAAATAAAGCGTTTTATTGTTATGCGAGCACGGAGTTTTTAGAAAGAGAAAAAGAAAA
AGCCAAAAATGAAAAACGCCCTTTCAGGTATTTAGACGAGTGGGCCACTTTAGAAAAAGACAAGCACCATGCCCCTGTGG
TGCGTTTGAAAGCCCCCAATCATGCGGTGTCTTTCAATGATGCGATCAAAAAAGAAGTGAAATTTGAGCCTGATGAATTG
GATTCTTTTGTGCTTTTGAGACAGGATAAAAGCCCTACTTATAATTTCGCTTGCACATGCGATGATTTGCTCTATGAAGT
CAGTCTGATTATTAGAGGCGAAGATCATGTGAGTAACACCCCCAAACAAATTTTAATCCAGCAAGCTTTAGGCTCAAACG
ATCCGATTGTTTATGCGCATTTGCCCATTATTTTAGATGAAGTAAGCGGTAAAAAGATGAGCAAAAGAGACGAAGCGTCC
AGCGTGAAATGGCTTTTAAATCAAGGGTTTTTACCGGTTGCGATTGCGAATTACCTCATCACTATCGGTAATAAAGTGCC
TAAGGAAGTTTTTAGCCTTGATGAAGCGATAGAGTGGTTTAGTTTAGAAAATCTTTCTAATTCCCCGGCTCATTTTAATT
TAAAATATTTAAAACACTTAAACCACGAGCATTTAAAGCTTTTAGACGATGAAAAGCTATTAAAACTCACTTCAATAAAA
GATAAAAATCTTTTAGGGCTTTTAAGATTGTTTATAGAAGAATGCGGCACGCTTTTAGAATTGAAAGAAAAAATTTCGTT
GTTTTTAGAGCCAAAAGATATTGTTAAAACTTACGAGAACGAAGATTTTAAAGAGCGTTGTTTAGCGCTTTTTAACGCCC
TAAAAAGCATGGATTTTCAAGTCTATAAGGATTTTGAAAGCTTTAAAAAAGAAGCCATGCGATTGAGCCAGCTTAAGGGT
AAGGATTTTTTCAAACCTTTACGCATCCTTTTGACCGGGAACTCGCATGGCGTTGAATTGCCTTTGATTTTCCCCTATAT
CCAAAGCCATTATCAAGAAGTTTTAAGGCTCAAAGCATGA

Upstream 100 bases:

>100_bases
TAAATGATGCTTGTTTGTGTTTGATAAAAACAGAACTACCACAGCATAATTAAGTATTCTTTAGGTATAATTAAAAACTA
TTTTTCAATAAAGGGTTTTT

Downstream 100 bases:

>100_bases
TTTTTTCTACCCTTATTAATGCGATAGCGGTGATTTTAAGCTCGCTCATTACGATTTATATGTGGGTAGTGATCATTTAT
TCGCTTATCAGCTTCGTGCA

Product: glutamylglutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase 1; GluRS 1 [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKFMGISWDKLVYQSHNIDYHRE
MAEKLLKENKAFYCYASTEFLEREKEKAKNEKRPFRYLDEWATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDEL
DSFVLLRQDKSPTYNFACTCDDLLYEVSLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEAS
SVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSNSPAHFNLKYLKHLNHEHLKLLDDEKLLKLTSIK
DKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYENEDFKERCLALFNALKSMDFQVYKDFESFKKEAMRLSQLKG
KDFFKPLRILLTGNSHGVELPLIFPYIQSHYQEVLRLKA

Sequences:

>Translated_439_residues
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKFMGISWDKLVYQSHNIDYHRE
MAEKLLKENKAFYCYASTEFLEREKEKAKNEKRPFRYLDEWATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDEL
DSFVLLRQDKSPTYNFACTCDDLLYEVSLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEAS
SVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSNSPAHFNLKYLKHLNHEHLKLLDDEKLLKLTSIK
DKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYENEDFKERCLALFNALKSMDFQVYKDFESFKKEAMRLSQLKG
KDFFKPLRILLTGNSHGVELPLIFPYIQSHYQEVLRLKA
>Mature_439_residues
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKFMGISWDKLVYQSHNIDYHRE
MAEKLLKENKAFYCYASTEFLEREKEKAKNEKRPFRYLDEWATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDEL
DSFVLLRQDKSPTYNFACTCDDLLYEVSLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEAS
SVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSNSPAHFNLKYLKHLNHEHLKLLDDEKLLKLTSIK
DKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYENEDFKERCLALFNALKSMDFQVYKDFESFKKEAMRLSQLKG
KDFFKPLRILLTGNSHGVELPLIFPYIQSHYQEVLRLKA

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=355, Percent_Identity=30.1408450704225, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI62241042, Length=258, Percent_Identity=25.1937984496124, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788743, Length=367, Percent_Identity=37.0572207084469, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI226510925, Length=245, Percent_Identity=30.2040816326531, Blast_Score=115, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71993394, Length=306, Percent_Identity=33.0065359477124, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17511007, Length=257, Percent_Identity=24.124513618677, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324540, Length=350, Percent_Identity=33.7142857142857, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321192, Length=123, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665321, Length=323, Percent_Identity=28.7925696594427, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 51178; Mature: 51178

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKF
CCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
MGISWDKLVYQSHNIDYHREMAEKLLKENKAFYCYASTEFLEREKEKAKNEKRPFRYLDE
HCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHH
WATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDELDSFVLLRQDKSPTYNFACTC
HHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHCCCEEEEECCCCCCEEEEECH
DDLLYEVSLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEAS
HHHHHEEHHEEECCHHCCCCHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCCCCHHHHH
SVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSNSPAHFNLKYLKHL
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHC
NHEHLKLLDDEKLLKLTSIKDKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYEN
CHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCC
EDFKERCLALFNALKSMDFQVYKDFESFKKEAMRLSQLKGKDFFKPLRILLTGNSHGVEL
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEE
PLIFPYIQSHYQEVLRLKA
HEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRFAPSPTGDMHIGNLRAAIFNYIVAKQQHKPFLIRIEDTDKERNIEGKDQEILEILKF
CCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
MGISWDKLVYQSHNIDYHREMAEKLLKENKAFYCYASTEFLEREKEKAKNEKRPFRYLDE
HCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHH
WATLEKDKHHAPVVRLKAPNHAVSFNDAIKKEVKFEPDELDSFVLLRQDKSPTYNFACTC
HHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHCCCEEEEECCCCCCEEEEECH
DDLLYEVSLIIRGEDHVSNTPKQILIQQALGSNDPIVYAHLPIILDEVSGKKMSKRDEAS
HHHHHEEHHEEECCHHCCCCHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCCCCHHHHH
SVKWLLNQGFLPVAIANYLITIGNKVPKEVFSLDEAIEWFSLENLSNSPAHFNLKYLKHL
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHC
NHEHLKLLDDEKLLKLTSIKDKNLLGLLRLFIEECGTLLELKEKISLFLEPKDIVKTYEN
CHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCC
EDFKERCLALFNALKSMDFQVYKDFESFKKEAMRLSQLKGKDFFKPLRILLTGNSHGVEL
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEE
PLIFPYIQSHYQEVLRLKA
HEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA