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The map label for this gene is adk [H]

Identifier: 108563024

GI number: 108563024

Start: 626518

End: 627093

Strand: Direct

Name: adk [H]

Synonym: HPAG1_0599

Alternate gene names: 108563024

Gene position: 626518-627093 (Clockwise)

Preceding gene: 108563023

Following gene: 108563025

Centisome position: 39.25

GC content: 39.24

Gene sequence:

>576_bases
ATGAAACAACTATTTTTGATTATTGGAGCCCCAGGGAGTGGTAAAACCACTGATGCAGAGCTTATCTCTAAGAATAACAG
CGAAACAATCGCTCATTTTTCTACTGGGGATTTATTAAGGGCTGAGAGCGCTAAAAAGACCGAGCGAGGCTTATTGATTG
AGAAATTCACTTCTCAAGGTGAATTAGTGCCTTTAGAGATTGTGGTAGAAACGATCCTTTCAGCGATTAAAAGTTCTAGC
AAAAGAATCATTTTAATTGATGGCTATCCTAGGAGCGTGGAACAAATGCAGGCTTTGGATAAGGAATTGAACGCTCAAAA
CGAAGTGATCTTAAAAAGCGTGATTGAAGTAGAAGTGAGTGAAAACACCGCTAAAGAAAGGGTTTTAGGGCGCTCTAGGG
GGGCTGATGACAATGAAAAGGTATTTCATAACCGCATGCGGGTGTTTTTAGATCCCTTAGCTGAAATCCAAAATTTCTAC
AAGGCTAAGCATTTGCATAAAGTTATCAATGGCGAAAGAAGCATTGAAGAAATCGTGCATGAAATGCAAGAGTATATCTT
GTCTTTTGGGAATTAA

Upstream 100 bases:

>100_bases
AAAGCTTCATGCTTATTGACTGATGCGCCTAGTCCTATTAATGAAGAACAATTAAGAGAATTACACATTCGCTTGAGAAA
ATAATTTAAAAGGATATGAT

Downstream 100 bases:

>100_bases
AATGTGCTCTCAAGGAGAATGAGCTGTGATTGGTGTCTATATCATTTCGTTAAAAGAAAGTCAAAGGCGTTTGGATACTG
AAAAACTCGTTTCAGAATCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSS
KRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFY
KAKHLHKVINGERSIEEIVHEMQEYILSFGN

Sequences:

>Translated_191_residues
MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSS
KRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFY
KAKHLHKVINGERSIEEIVHEMQEYILSFGN
>Mature_191_residues
MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSS
KRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFY
KAKHLHKVINGERSIEEIVHEMQEYILSFGN

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=189, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=35.2941176470588, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=35.2941176470588, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=30.2083333333333, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI4502013, Length=200, Percent_Identity=27.5, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7524346, Length=200, Percent_Identity=27.5, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923437, Length=126, Percent_Identity=34.1269841269841, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI1786680, Length=140, Percent_Identity=30.7142857142857, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=36.8131868131868, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=28.3422459893048, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=29.5698924731183, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=24.6511627906977, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=129, Percent_Identity=34.8837209302326, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=27.2277227722772, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221459597, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356893, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737899, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645822, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647141, Length=191, Percent_Identity=31.9371727748691, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663208, Length=191, Percent_Identity=31.9371727748691, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI22026816, Length=127, Percent_Identity=36.2204724409449, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21464; Mature: 21464

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQG
CCEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHCCCC
ELVPLEIVVETILSAIKSSSKRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVS
CEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFYKAKHLHKVINGERSIEEIVH
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EMQEYILSFGN
HHHHHHHHCCC
>Mature Secondary Structure
MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQG
CCEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHCCCC
ELVPLEIVVETILSAIKSSSKRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVS
CEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFYKAKHLHKVINGERSIEEIVH
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EMQEYILSFGN
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA