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The map label for this gene is aspS [H]

Identifier: 108563023

GI number: 108563023

Start: 624768

End: 626501

Strand: Direct

Name: aspS [H]

Synonym: HPAG1_0598

Alternate gene names: 108563023

Gene position: 624768-626501 (Clockwise)

Preceding gene: 108563022

Following gene: 108563024

Centisome position: 39.14

GC content: 40.54

Gene sequence:

>1734_bases
ATGCGAAGTCATTTCTGCACAGAAATTAGTGAAAAAGATGTGGGTAAAACCATCAAAGTGGCCGGGTGGTGTAACACTTA
TAGAGACCATGGAGGCGTGGTTTTTATTGATTTAAGGGATAAAAGCGGTTTAGTGCAATTAGTCTGTGATCCTAGCTCTA
AGGCTTATGAAAAGGCTTTAGAAGTCAGGAGCGAATTTGTGCTAGTGGCTAAAGGAAGAGTGCGTTTGAGAGGGCCTGGT
TTAGAAAACCCTAAACTAAAAACGGGTAAAATTGAAATCGTTTTAGAAGAATTAGTCATTGAAAATAAAAGCGCTACCCC
ACCGATTGAAATTGGCAATAAAAACGTGAATGAAGATTTGCGCTTGAAATACCGCTATTTGGATTTACGCTCTTTGAATG
CTTATGAAATCTTTAAATTGCGCAGCGAAGTGGCTTTAATTACTCGTAACACTCTAGCCCAAAAGGGCTTTTTAGAGATT
GAAACCCCCATTTTGTCTAAAACCACGCCTGAGGGGGCTAGGGATTATTTAGTGCCAAGCAGGGTGCATGAGGGCGAATT
TTTCGCGCTTCCCCAAAGCCCGCAATTATTCAAACAGCTCTTAATGGTGGGGGGAATGGATAGGTATTTTCAAATCGCTC
GTTGCTTTAGAGATGAAGATTTGAGAGCGGACAGGCAGCCAGAATTCACGCAAATTGATGCGGAAATGAGTTTTTGTGAT
GAAAATGATGTGATGGGCGTGGTGGAAGATTTGTTGCAAGCGATTTTTAAAGCGGTTGGGCATACTATTTCTAAACCTTT
TAAACGCATGCCTTATAAGGAAGCGATGGAAAATTACGGGAGCGATAAGCCGGATTTACGCTTTGAATTGCCTTTAATAG
AAGTGGGGGATTGTTTTAGGGACAGCTCAAACGCTATTTTTTCTAATATCGCAAAAGATCCTAAAAACAAACGCATTAAA
GCTTTGAACGTTAAGGGGGCTGATGCGGTTTTTAGCCGTAGCGTTTTAAAAGAATTAGAAGAATTTGTGCGCCAATTTGG
GGCTCAAGGTTTGGCGTATTTGCAAATTAAAGAAGATGGGATTAAAGGGCCTTTAGTTAAATTTTTGAGCGAAAAGGGGC
TTAAGAATATTTTAGAAAAAACTGGTGCACAAACTGGGGATATTGTCTTTTTTGGAGCCGGGGATAAAAAAATCGTGTTA
GATTACATGGGGCGTTTGCGCTTGAAGGTGGCTGAAACGCTTGATTTGATTGATAAAGACGCTTTGAATTTCTTATGGGT
AGTCAATTTTCCCATGTTTGAAAAAACCGAAAACGGCTACCATGCTGCGCACCACCCTTTTACGATGCCTAAAAATATAG
AATGCGAAGATATAGAAGAGGTTGAAGCGCATGCGTATGATGTGGTGCTTAATGGCGTGGAGCTTGGTGGGGGGAGCATT
AGGATTCATAAAGAAGAAATGCAAAAAAAAGTCTTTGAAAAAATCAATATCCACGAAGAGGAAGCGCAAAAGAAATTTGG
CTTTTTACTAGAAGCGCTAAAGTTTGGCGCTCCTCCTCATGGGGGCTTTGCGATAGGCTTTGATCGCTTGATCATGCTAA
TGACCAAATCTCATAGCATTAGAGATGTGATCGCTTTCCCTAAAACGCAAAAAGCTTCATGCTTATTGACTGATGCGCCT
AGTCCTATTAATGAAGAACAATTAAGAGAATTACACATTCGCTTGAGAAAATAA

Upstream 100 bases:

>100_bases
GATGGTTTTGTGGTAAAATCTAACATTCTTGAAATCCATGAAATGCTTAAAAAAACGCTTTCATAAATTTAATTTTTGTT
TTAATTTAAAGGGATAAAAC

Downstream 100 bases:

>100_bases
TTTAAAAGGATATGATATGAAACAACTATTTTTGATTATTGGAGCCCCAGGGAGTGGTAAAACCACTGATGCAGAGCTTA
TCTCTAAGAATAACAGCGAA

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKALEVRSEFVLVAKGRVRLRGPG
LENPKLKTGKIEIVLEELVIENKSATPPIEIGNKNVNEDLRLKYRYLDLRSLNAYEIFKLRSEVALITRNTLAQKGFLEI
ETPILSKTTPEGARDYLVPSRVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCD
ENDVMGVVEDLLQAIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFRDSSNAIFSNIAKDPKNKRIK
ALNVKGADAVFSRSVLKELEEFVRQFGAQGLAYLQIKEDGIKGPLVKFLSEKGLKNILEKTGAQTGDIVFFGAGDKKIVL
DYMGRLRLKVAETLDLIDKDALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSI
RIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSIRDVIAFPKTQKASCLLTDAP
SPINEEQLRELHIRLRK

Sequences:

>Translated_577_residues
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKALEVRSEFVLVAKGRVRLRGPG
LENPKLKTGKIEIVLEELVIENKSATPPIEIGNKNVNEDLRLKYRYLDLRSLNAYEIFKLRSEVALITRNTLAQKGFLEI
ETPILSKTTPEGARDYLVPSRVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCD
ENDVMGVVEDLLQAIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFRDSSNAIFSNIAKDPKNKRIK
ALNVKGADAVFSRSVLKELEEFVRQFGAQGLAYLQIKEDGIKGPLVKFLSEKGLKNILEKTGAQTGDIVFFGAGDKKIVL
DYMGRLRLKVAETLDLIDKDALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSI
RIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSIRDVIAFPKTQKASCLLTDAP
SPINEEQLRELHIRLRK
>Mature_577_residues
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKALEVRSEFVLVAKGRVRLRGPG
LENPKLKTGKIEIVLEELVIENKSATPPIEIGNKNVNEDLRLKYRYLDLRSLNAYEIFKLRSEVALITRNTLAQKGFLEI
ETPILSKTTPEGARDYLVPSRVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCD
ENDVMGVVEDLLQAIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFRDSSNAIFSNIAKDPKNKRIK
ALNVKGADAVFSRSVLKELEEFVRQFGAQGLAYLQIKEDGIKGPLVKFLSEKGLKNILEKTGAQTGDIVFFGAGDKKIVL
DYMGRLRLKVAETLDLIDKDALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSI
RIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSIRDVIAFPKTQKASCLLTDAP
SPINEEQLRELHIRLRK

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=595, Percent_Identity=39.327731092437, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI5031815, Length=253, Percent_Identity=30.8300395256917, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194272210, Length=253, Percent_Identity=30.8300395256917, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI45439306, Length=168, Percent_Identity=33.9285714285714, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI226491502, Length=257, Percent_Identity=30.3501945525292, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI4758762, Length=286, Percent_Identity=28.3216783216783, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788173, Length=588, Percent_Identity=48.6394557823129, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789256, Length=314, Percent_Identity=28.6624203821656, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790571, Length=289, Percent_Identity=26.643598615917, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32566633, Length=599, Percent_Identity=37.228714524207, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71994340, Length=300, Percent_Identity=25.6666666666667, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535925, Length=301, Percent_Identity=26.2458471760797, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535927, Length=300, Percent_Identity=25.6666666666667, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17551876, Length=313, Percent_Identity=25.2396166134185, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71984122, Length=293, Percent_Identity=25.5972696245734, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325153, Length=640, Percent_Identity=33.4375, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6323011, Length=302, Percent_Identity=27.8145695364238, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320242, Length=257, Percent_Identity=29.1828793774319, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321807, Length=287, Percent_Identity=26.1324041811847, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584738, Length=607, Percent_Identity=36.9028006589786, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24640849, Length=249, Percent_Identity=28.5140562248996, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640851, Length=249, Percent_Identity=28.5140562248996, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136276, Length=268, Percent_Identity=29.4776119402985, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921528, Length=280, Percent_Identity=27.1428571428571, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 65406; Mature: 65406

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKAL
CCCCCCCCCCHHCCCCEEEEEECHHHHHCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
EVRSEFVLVAKGRVRLRGPGLENPKLKTGKIEIVLEELVIENKSATPPIEIGNKNVNEDL
HHHHCEEEEECCEEEEECCCCCCCCCCCCHHEEEEHHHHHCCCCCCCCCCCCCCCCCCCC
RLKYRYLDLRSLNAYEIFKLRSEVALITRNTLAQKGFLEIETPILSKTTPEGARDYLVPS
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHCCCCC
RVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCD
CCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHCCC
ENDVMGVVEDLLQAIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCEEECCHHHC
DSSNAIFSNIAKDPKNKRIKALNVKGADAVFSRSVLKELEEFVRQFGAQGLAYLQIKEDG
CCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
IKGPLVKFLSEKGLKNILEKTGAQTGDIVFFGAGDKKIVLDYMGRLRLKVAETLDLIDKD
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHH
ALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSI
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECEEECCCEE
RIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSI
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCCH
RDVIAFPKTQKASCLLTDAPSPINEEQLRELHIRLRK
HHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKAL
CCCCCCCCCCHHCCCCEEEEEECHHHHHCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
EVRSEFVLVAKGRVRLRGPGLENPKLKTGKIEIVLEELVIENKSATPPIEIGNKNVNEDL
HHHHCEEEEECCEEEEECCCCCCCCCCCCHHEEEEHHHHHCCCCCCCCCCCCCCCCCCCC
RLKYRYLDLRSLNAYEIFKLRSEVALITRNTLAQKGFLEIETPILSKTTPEGARDYLVPS
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHCCCCC
RVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCD
CCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHCCC
ENDVMGVVEDLLQAIFKAVGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEECCEEECCHHHC
DSSNAIFSNIAKDPKNKRIKALNVKGADAVFSRSVLKELEEFVRQFGAQGLAYLQIKEDG
CCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
IKGPLVKFLSEKGLKNILEKTGAQTGDIVFFGAGDKKIVLDYMGRLRLKVAETLDLIDKD
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHH
ALNFLWVVNFPMFEKTENGYHAAHHPFTMPKNIECEDIEEVEAHAYDVVLNGVELGGGSI
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEECEEECCCEE
RIHKEEMQKKVFEKINIHEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSHSI
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCCH
RDVIAFPKTQKASCLLTDAPSPINEEQLRELHIRLRK
HHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA