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The map label for this gene is iscS [H]

Identifier: 108562647

GI number: 108562647

Start: 225733

End: 226902

Strand: Direct

Name: iscS [H]

Synonym: HPAG1_0222

Alternate gene names: 108562647

Gene position: 225733-226902 (Clockwise)

Preceding gene: 108562646

Following gene: 108562648

Centisome position: 14.14

GC content: 44.44

Gene sequence:

>1170_bases
TTGACCTTGTTACAACGAATTTATTTAGACAATAACGCTACAACCAGGATTGATCCTAAAGTCAAAGAAATCATGGATCC
TTTTTTAAGGGATCATTATGGGAATCCTAGCTCGTTGCACCAGTTTGGCACAGAAACCCACCCAGCCATTGCAGAAGCGC
TAGATAAGCTTTATAAAGGCATTAACGCTAGGGATATAGATGATGTGATCATCACTTCTTGTGCGACAGAAAGCAATAAT
TGGGTTTTAAAGGGCGTGTATTTTGATGAATGCTTGAAAAAAGGTAAAAACCATATTGTAACCACGGTTGCAGAGCATCC
GGCGGTGCGATCCACTTGTAATTTTTTAGAAAGCTTGGGGGTGGAGGTTACTTACTTGCCCATTAATGAGCATGGGAGTA
TTACCGCCGAGCAAGTCAAAGAAGCGATCACAGAAAAAACCGCTCTAGTGAGCGTGATGTGGGCGAATAATGAAACCGGT
CTCATTTTCCCTATTGAAGAAATTGGGGCTATTTGTAAAGAAAAGGGCGTGTTGTTCCATACCGATGCGGTGCAAGCGAT
TGGTAAAATCCCTGTAGATGTGTTGAAAGCGAATGTAGATTTCCTTTCTTTTAGCGCGCACAAGTTTCATGGGCCTAAAG
GCATTGGGGGGTTGTATATTAGAAGTGGGGTGGGATTGACCCCTCTTTTTCATGGCGGGGAGCATATGAATGGCAGGCGC
AGCGGGACTTTGAACGTGCCTTATATCGTGGGCATGGGCGAAGCGATGAGATTAGCCGTAGAGCATTTAGATTATGAAAA
AGAAGTGGTAGGGAAGTTGCGCGACAAATTAGAAGAAGCGCTTTTGAAAATCCCTGATGTGATGGTGGTGGGGGATCGAA
TCCATCGTGTGCCTAACACGACTTTAGTCAGCGTGAGAGGGATTGAAGGAGAGGCCATGCTGTGGGATTTGAATCGCTCT
AATATCGCCGCTTCCACAGGGAGCGCGTGCGCGAGTGAAGATTTAGAGGCTAATCCTGTCATGGTAGCGATTGGAGCGAG
TAAAGAATTGGCTCATACCGCTATCAGGCTTTCATTGAGCCGTTTTAACACGGAAGCTGAAATTGATAAAACGATTGAAG
TTTTCTCTCAAGCGGCTATAAGATTGAGAAACATTTCAAGCTCTTATTAA

Upstream 100 bases:

>100_bases
AAATTCATCTTATTTTAAGTTAAAATTAAGAAAATATCTTGTATTTAATCATAATTTAGACTTAGATAAGAAAATCTATG
TAAAATTTTTGAGGAGAATA

Downstream 100 bases:

>100_bases
AAAGAATATAAAGGAATCAAAATGGCAAAACATGATTTAGTGGGTTCGGTTCTCTGGGACGCGTATTCTAAAGAAGTTCA
AAGGCGCATGGATAACCCCA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTLLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNN
WVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETG
LIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRR
SGTLNVPYIVGMGEAMRLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRS
NIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAIRLRNISSSY

Sequences:

>Translated_389_residues
MTLLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNN
WVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETG
LIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRR
SGTLNVPYIVGMGEAMRLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRS
NIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAIRLRNISSSY
>Mature_388_residues
TLLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNW
VLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGL
IFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRS
GTLNVPYIVGMGEAMRLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRSN
IAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAIRLRNISSSY

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=42.5257731958763, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI156713448, Length=423, Percent_Identity=34.0425531914894, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=43.8961038961039, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=25.7575757575758, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789175, Length=392, Percent_Identity=25, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=41.8604651162791, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17533177, Length=323, Percent_Identity=34.0557275541796, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=44.9086161879896, Blast_Score=296, Evalue=4e-81,
Organism=Drosophila melanogaster, GI20129463, Length=387, Percent_Identity=42.3772609819121, Blast_Score=288, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017773
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42688; Mature: 42557

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKG
CCHHHEEEECCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCC
INARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLG
CCCCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHCCCCHHHHHHHHHHCC
VEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFH
CEEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHHHHHHHHCCCEEE
TDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRR
CHHHHHHHCCCHHHHHCCCCEEEECHHHCCCCCCCCCEEEECCCCCCCEECCCCCCCCCC
SGTLNVPYIVGMGEAMRLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNT
CCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCC
TLVSVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLS
EEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
RFNTEAEIDKTIEVFSQAAIRLRNISSSY
HCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKG
CHHHEEEECCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCC
INARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLG
CCCCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHCCCCHHHHHHHHHHCC
VEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFH
CEEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHHHHHHHHCCCEEE
TDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRR
CHHHHHHHCCCHHHHHCCCCEEEECHHHCCCCCCCCCEEEECCCCCCCEECCCCCCCCCC
SGTLNVPYIVGMGEAMRLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNT
CCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCC
TLVSVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLS
EEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
RFNTEAEIDKTIEVFSQAAIRLRNISSSY
HCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA