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The map label for this gene is dxr [H]

Identifier: 108562642

GI number: 108562642

Start: 222095

End: 223201

Strand: Direct

Name: dxr [H]

Synonym: HPAG1_0217

Alternate gene names: 108562642

Gene position: 222095-223201 (Clockwise)

Preceding gene: 108562641

Following gene: 108562643

Centisome position: 13.91

GC content: 41.82

Gene sequence:

>1107_bases
ATGGTTGTTTTAGGAAGCACCGGCTCTATTGGGAAAAACGCCCTAAAAATCGCAAAAAAATTTGGCGTAGAAATAGAAGC
CTTGAGCTGTGGGAAAAATATCGCTTTAATCAATGAACAAATCAAAGTTTTCAAACCCAAGAAGGTGGCGATTTTAGATC
CTAGCGATTTGAATAATTTAGAGCCTTTGGGCGCAGAAGTGTTTGTAGGGCTAGACGGCATTGATGCGATGATAGAAGAG
TGCGTTTCCAATTTAGTCCTTAACGCCATTGTGGGCGTGGCAGGATTGAAAGCGAGCTTTAAAAGCTTACAAAGGAACAA
AAAACTAGCCCTAGCGAATAAAGAGAGCTTAGTGAGCGCGGGGAATTTATTAGACATTTCACAAATCACGCCCGTTGATA
GCGAGCATTTTGGTTTGTGGGCGTTGTTGCAAAACAAGACTTTAAAGCCTAAATCTTTAATCATTAGCGCGAGTGGGGGG
GCTTTTAGGGACACGCCTTTAGAACTTATCGCTATTCAAAACGCGCAAAACGCGCTCAAACACCCTAATTGGAGCATGGG
ATCTAAAATCACCATTGATTCAGCGAGCATGGTCAATAAGCTTTTTGAAATTTTAGAAACTTACTGGCTTTTTGGCACGT
CTTTAAAGATTGATGCGCTGATTGAAAGGAGTTCTATCGTGCATGCTTTGGTGGAGTTTGAAGACAACTCTATCATCGTG
CATTTAGCGAGCGCGGACATGCAATTACCTATAAGCTATGCGATCGATCCGAAGTTGGCCTCTTTGAATGCGTCTATCAA
GCCACTAGATTTATACGCTTTAAACGCGATTAAATTTGAACCCATTAGCATGGAGCGCTACACTTTGTGGCGTTATAAAG
ACTTGTTGTTAGAAAACCCAAAGCTTGGCGTGGTGCTGAATGCGAGTAATGAGGTGGCGATGGAGAAGTTTTTAAATCAA
GAGATCGCTTTTGGTGGCCTTATCCAAACCATTTCTCAAGCCTTAGAATTGTATGCTAAAAAATCTTTCAAGCTCTCTAG
TTTAGATGAAGTGCTAGAGCTAGACAAAGAAGTTAGGGAGCGTTTTGAAAATGTAGCGGGAGTGTAG

Upstream 100 bases:

>100_bases
AGACCGATTGGATTCCATGCTTTTTGGGGCTTTAGGCTTGCATGCGTTGTTGTATTTTTTAGAAATTTGGAAAGAAACGG
CGGTGTTTTTGGGGGATTGA

Downstream 100 bases:

>100_bases
TATAATAAGATTTTGCTTTTAATAGCGTTTTATTCCAATTAGGAGTTTTTATGGGGTTAAAAAATAAAATCAAGGGTTTT
ATTAAAGAGAGAATGCCTTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNLEPLGAEVFVGLDGIDAMIEE
CVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAGNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGG
AFRDTPLELIAIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIV
HLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENPKLGVVLNASNEVAMEKFLNQ
EIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRERFENVAGV

Sequences:

>Translated_368_residues
MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNLEPLGAEVFVGLDGIDAMIEE
CVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAGNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGG
AFRDTPLELIAIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIV
HLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENPKLGVVLNASNEVAMEKFLNQ
EIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRERFENVAGV
>Mature_368_residues
MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNLEPLGAEVFVGLDGIDAMIEE
CVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAGNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGG
AFRDTPLELIAIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIV
HLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENPKLGVVLNASNEVAMEKFLNQ
EIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRERFENVAGV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=32.48730964467, Blast_Score=182, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40264; Mature: 40264

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNL
CEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCEEEEECCCEEECCCEEEEECCCCCCCC
EPLGAEVFVGLDGIDAMIEECVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCC
GNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLELIAIQNAQNALK
CCEEEHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHC
HPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIV
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHEEECCCEEEE
HLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENP
EEECCCCCCCEEEEECCCHHHCCCCCCEEEEEEECEEEECCCCCCCEEHHHHHHHHHCCC
KLGVVLNASNEVAMEKFLNQEIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RFENVAGV
HHHHHCCC
>Mature Secondary Structure
MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNL
CEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCEEEEECCCEEECCCEEEEECCCCCCCC
EPLGAEVFVGLDGIDAMIEECVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCC
GNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLELIAIQNAQNALK
CCEEEHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHC
HPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIV
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHEEECCCEEEE
HLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENP
EEECCCCCCCEEEEECCCHHHCCCCCCEEEEEEECEEEECCCCCCCEEHHHHHHHHHCCC
KLGVVLNASNEVAMEKFLNQEIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RFENVAGV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA