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The map label for this gene is glyA [H]

Identifier: 108562605

GI number: 108562605

Start: 185869

End: 187119

Strand: Direct

Name: glyA [H]

Synonym: HPAG1_0180

Alternate gene names: 108562605

Gene position: 185869-187119 (Clockwise)

Preceding gene: 108562604

Following gene: 108562606

Centisome position: 11.64

GC content: 40.85

Gene sequence:

>1251_bases
ATGGCGTATTTTTTAGAACAAAGCGATAGTGAAATTTTTGAATTGATCTTTGAAGAATATAAGCGGCAAAATGAGCATTT
AGAAATGATAGCGAGCGAAAATTACACTTTTCCTAGTGTTATGGAAGCTATGGGAAGCATTTTAACGAATAAATACGCTG
AGGGCTATCCTAACAAGCGCTATTATGGAGGCTGTGAAGTGGTGGATAAAATAGAAAGCCTAGCCATAGAAAGGGCTAAA
AAGCTTTTTAATTGCCAGTTCGCTAATGTGCAAGCGCACTCAGGCTCACAAGCTAATAACGCTGTCTATCACGCTCTTTT
AAAGCCTTATGACAAGATTTTAGGCATGGATTTAAGCTGTGGAGGGCATTTAACGCATGGCGCTAAAGTGAGCTTAACCG
GCAAGCATTATCAGAGCTTTTCTTATGGCGTGAATTTGGATGGCTATATTGATTATGAAGAAGCGCTAAAGATCGCTCAA
AGCGTTAAGCCAGAAATCATCGTGTGCGGGTTTTCAGCCTATCCAAGGGAGATTGATTTTAAGAAATTTAGAGAAATCGC
TGATGAAGTGGGGGCGTTACTATTAGGCGATATAGCCCATGTGGCAGGGCTTGTGGTAACTGGTGAGCATGCCCATCCTT
TCCCGCATTGCCATGTGGTTTCAAGCACCACTCATAAGACCTTAAGAGGGCCTAGAGGGGGGCTTATTTTAACCAATGAT
GAAGAGATAGCGGCTAAGATTGATAAAGCGATTTTTCCAGGGACTCAAGGCGGGCCTTTGATGCATGTGATTGCTGCTAA
AGCGGTGGGGTTTAAAGAGAATCTAAAACCAGAATTTAAAGCTTACGCAAAATTAGTGAAATCTAACATGCAAGTTTTGG
CTAAAGCGTTAAAAGAAAAAAACCATAAGTTAGTGAGCGGTGGCACTTCTAACCATTTACTTTTAATGGATTTCTTAGAT
AAGCCTTATAGCGGGAAAGACGCTGATATTGCATTAGGGAATGCTGGAATCACCGTGAATAAAAACACCATTCCTGGCGA
AACGCGCAACCCTTTTGTAACGAGCGGGATAAGGATTGGCTCAGCGGCGTTGAGCGCAAGGGGCATGGGAGCTAAGGAAT
TTGAAATCATAGGGAATAAAATATCAGATATTTTGAATGATATTAATAATGTTAGTTTGCAATTGCATGTGAAAGAAGAA
TTGAAGGCCATGGCTAATCAATTCCCTGTGTATCAACAACCTATTTTTTAA

Upstream 100 bases:

>100_bases
TAGTGATGTTACTCACTGGAGCTAAAAGCATTAAAGATGTGATTTTATTCCCAGCGATGCGTCCTGTTAAAAACGATTTT
AATATTGAGAGTGGAGAATA

Downstream 100 bases:

>100_bases
GGGAGTCAAGATGACAGAAATGGAATTAAAGCTCATTAAGATAGACACAAGCCATTATTTTGAAAAAAAACCAGGCTTGG
GGGAGAGGGTGGATTATGCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAYFLEQSDSEIFELIFEEYKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKRYYGGCEVVDKIESLAIERAK
KLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQ
SVKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
EEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAKALKEKNHKLVSGGTSNHLLLMDFLD
KPYSGKDADIALGNAGITVNKNTIPGETRNPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEE
LKAMANQFPVYQQPIF

Sequences:

>Translated_416_residues
MAYFLEQSDSEIFELIFEEYKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKRYYGGCEVVDKIESLAIERAK
KLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQ
SVKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
EEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAKALKEKNHKLVSGGTSNHLLLMDFLD
KPYSGKDADIALGNAGITVNKNTIPGETRNPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEE
LKAMANQFPVYQQPIF
>Mature_415_residues
AYFLEQSDSEIFELIFEEYKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKRYYGGCEVVDKIESLAIERAKK
LFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQS
VKPEIIVCGFSAYPREIDFKKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTNDE
EIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAKALKEKNHKLVSGGTSNHLLLMDFLDK
PYSGKDADIALGNAGITVNKNTIPGETRNPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEEL
KAMANQFPVYQQPIF

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=418, Percent_Identity=43.5406698564593, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI261862352, Length=418, Percent_Identity=43.5406698564593, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI261862350, Length=418, Percent_Identity=43.5406698564593, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI261862348, Length=418, Percent_Identity=43.5406698564593, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI261862346, Length=417, Percent_Identity=43.4052757793765, Blast_Score=314, Evalue=8e-86,
Organism=Homo sapiens, GI22547186, Length=432, Percent_Identity=41.8981481481481, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI22547189, Length=418, Percent_Identity=40.1913875598086, Blast_Score=281, Evalue=7e-76,
Organism=Escherichia coli, GI1788902, Length=405, Percent_Identity=53.8271604938272, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=43, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=43, Blast_Score=308, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6319739, Length=429, Percent_Identity=38.9277389277389, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=41.0579345088161, Blast_Score=299, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=43.9393939393939, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=43.9393939393939, Blast_Score=331, Evalue=7e-91,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45727; Mature: 45596

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFLEQSDSEIFELIFEEYKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKR
CCEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSC
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCGFSAYPREIDF
CCCCCCCCEEEEECCHHCCEECCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCHHHHCCCCCCEEEECC
EEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAKALKEK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NHKLVSGGTSNHLLLMDFLDKPYSGKDADIALGNAGITVNKNTIPGETRNPFVTSGIRIG
CCEEEECCCCCCEEEEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCEEECCEEEC
SAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEELKAMANQFPVYQQPIF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AYFLEQSDSEIFELIFEEYKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKR
CEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSC
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGHLTHGAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCGFSAYPREIDF
CCCCCCCCEEEEECCHHCCEECCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPHCHVVSSTTHKTLRGPRGGLILTND
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCHHHHCCCCCCEEEECC
EEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAKALKEK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NHKLVSGGTSNHLLLMDFLDKPYSGKDADIALGNAGITVNKNTIPGETRNPFVTSGIRIG
CCEEEECCCCCCEEEEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCEEECCEEEC
SAALSARGMGAKEFEIIGNKISDILNDINNVSLQLHVKEELKAMANQFPVYQQPIF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA