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The map label for this gene is lysS [H]

Identifier: 108562604

GI number: 108562604

Start: 184364

End: 185869

Strand: Direct

Name: lysS [H]

Synonym: HPAG1_0179

Alternate gene names: 108562604

Gene position: 184364-185869 (Clockwise)

Preceding gene: 108562603

Following gene: 108562605

Centisome position: 11.55

GC content: 40.17

Gene sequence:

>1506_bases
ATGTTTTCTAACCAATACATCCAACAGCGCATCCATAAAGCCAATAGCTTGAGAGAAGAAGGGAAAAACCCTTATCAAAA
TGGCTTGAAACGAAGCCTTACCAACGCCGCTTTTTTAGAAAAATACGCTTATGTTAAGGATTTAGAAGAGCCTAAAGACA
AAGAAAAATGCGAGAGTATTGTAGGGAGGGTCAAGCTTTTGCGTTTAATGGGTAAGGCTTGTTTTATTAAAGTTGAAGAT
GAAAGCGCGATTTTGCAAGCTTATGTTTCGCAAAATGAATTGAATGATGAGTTTAAAAGCCTGAAAAAGCATTTAGAAGT
GGGCGATATTGTGTTGGTGAAAGGTTTCCCTTTTGCTACCAAAACCGGTGAATTGAGCGTTCATGCCCTAGAATTTCATA
TTTTAAGCAAAACCATTGTGCCTTTACCTGAAAAGTTTCATGGACTGAGCGATATAGAATTGCGCTACCGCCAGCGCTAC
TTGGATTTGATCGTCAATCCTGGCGTTAAAGATGTGTTTAAAAAGCGCAGTTTGATTGTCTCTAGCGTGCGGAAATTCTT
TGAAATGGAAGGGTTTTTGGAAGTGGAAACCCCTATGATGCACCCCATTCCTGGCGGAGCGAACGCAAGGCCTTTTATCA
CTTATCATAACGCTTTAGAAGTTGAGAGGTATTTGAGAATCGCTCCAGAATTATACCTTAAACGCTTGATTGTGGGGGGT
TTTGAAGCGGTGTTTGAAATCAATCGTAATTTCAGGAATGAGGGCATGGATCACAGCCATAACCCCGAATTTACGATGAT
TGAATTTTATTGGGCGTATCACACTTATGAAGATTTGATTGAACTCAGTAAGAGGCTATTTGACTACTTGCTAAAGACTT
TGAACTTACCTTCAAAAATCATTTATAACGATATGGAAGTGGATTTCAACCAAACGAGCGTGATTTCCTATTTGGACGCT
TTAGAAACGATAGGGGGCATCAGTAAGGATATTTTAGAAAAAGAAGACAGGCTTTTGGCTTATTTGTTAGAGCAAGGCAT
CAAAGTAGAACCAAACCTCACTTATGGTAAATTGCTCGCTGAAGCGTTTGATCATTTTGTAGAGCACCAACTCATTAACC
CCACTTTTGTAACCCAATACCCTATTGAGATTAGCCCCTTAGCCAGACGCAACGATAGTAACCCTAATATTGCTGACAGG
TTTGAATTGTTCATTGCAGGAAAAGAAATCGCTAACGGCTTTAGCGAGTTGAACGACCCTTTGGATCAATTAGAACGCTT
TAAAAATCAAGTGGCTGAAAAAGAAAAAGGCGATGAAGAAGCCCAATACATGGATGAAGATTATGTGTGGGCCCTAGCCC
ATGGAATGCCCCCCACTGCAGGGCAAGGCATAGGCATTGACCGATTAGTGATGTTACTCACTGGAGCTAAAAGCATTAAA
GATGTGATTTTATTCCCAGCGATGCGTCCTGTTAAAAACGATTTTAATATTGAGAGTGGAGAATAA

Upstream 100 bases:

>100_bases
AAAGGCTAAAGACTTGCCTAAAAACATGCTAGATCCAAAAGCTAACCAAACCCCACCAAACCCCACCCCATCTAATAAAG
AACCCCTATAAAGGCATCAC

Downstream 100 bases:

>100_bases
TGGCGTATTTTTTAGAACAAAGCGATAGTGAAATTTTTGAATTGATCTTTGAAGAATATAAGCGGCAAAATGAGCATTTA
GAAATGATAGCGAGCGAAAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESIVGRVKLLRLMGKACFIKVED
ESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRY
LDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGG
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKIIYNDMEVDFNQTSVISYLDA
LETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLAEAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADR
FELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
DVILFPAMRPVKNDFNIESGE

Sequences:

>Translated_501_residues
MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESIVGRVKLLRLMGKACFIKVED
ESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRY
LDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGG
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKIIYNDMEVDFNQTSVISYLDA
LETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLAEAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADR
FELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
DVILFPAMRPVKNDFNIESGE
>Mature_501_residues
MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESIVGRVKLLRLMGKACFIKVED
ESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRY
LDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGG
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKIIYNDMEVDFNQTSVISYLDA
LETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLAEAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADR
FELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
DVILFPAMRPVKNDFNIESGE

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=515, Percent_Identity=39.8058252427184, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI194272210, Length=515, Percent_Identity=39.8058252427184, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI45439306, Length=464, Percent_Identity=23.7068965517241, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789256, Length=504, Percent_Identity=50.1984126984127, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1790571, Length=498, Percent_Identity=50, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI87082379, Length=335, Percent_Identity=31.6417910447761, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1788173, Length=246, Percent_Identity=28.8617886178862, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17535925, Length=504, Percent_Identity=40.0793650793651, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17535927, Length=504, Percent_Identity=40.0793650793651, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI71994340, Length=499, Percent_Identity=40.2805611222445, Blast_Score=345, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17551876, Length=350, Percent_Identity=24.5714285714286, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI32566633, Length=266, Percent_Identity=25.187969924812, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=512, Percent_Identity=39.2578125, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=31.7991631799163, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323011, Length=485, Percent_Identity=25.1546391752577, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640849, Length=506, Percent_Identity=40.7114624505929, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640851, Length=506, Percent_Identity=40.7114624505929, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57663; Mature: 57663

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESI
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGRVKLLRLMGKACFIKVEDESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFAT
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
KTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRYLDLIVNPGVKDVFKKRSLIV
CCCCEEEEEHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKI
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IYNDMEVDFNQTSVISYLDALETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLA
HCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHH
EAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDP
HHHHHHHHHHCCCCEEEEECCCEECCHHHCCCCCCCHHHHHHHEEECHHHHHHHHHHCCH
LDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
HHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHHH
DVILFPAMRPVKNDFNIESGE
HHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFSNQYIQQRIHKANSLREEGKNPYQNGLKRSLTNAAFLEKYAYVKDLEEPKDKEKCESI
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VGRVKLLRLMGKACFIKVEDESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFAT
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
KTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRYLDLIVNPGVKDVFKKRSLIV
CCCCEEEEEHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEVERYLRIAPELYLKRLIVGG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKI
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IYNDMEVDFNQTSVISYLDALETIGGISKDILEKEDRLLAYLLEQGIKVEPNLTYGKLLA
HCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHH
EAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDP
HHHHHHHHHHCCCCEEEEECCCEECCHHHCCCCCCCHHHHHHHEEECHHHHHHHHHHCCH
LDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
HHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHHH
DVILFPAMRPVKNDFNIESGE
HHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA