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The map label for this gene is fba [H]

Identifier: 108562597

GI number: 108562597

Start: 178037

End: 178960

Strand: Direct

Name: fba [H]

Synonym: HPAG1_0172

Alternate gene names: 108562597

Gene position: 178037-178960 (Clockwise)

Preceding gene: 108562596

Following gene: 108562598

Centisome position: 11.15

GC content: 43.29

Gene sequence:

>924_bases
ATGCTAGTTAAAGGTAATGAAATCTTATTGAAAGCCCATGAAGAAGGTTATGGGGTGGGGGCGTTTAATTTCGTGAATTT
TGAAATGCTAAACGCTATTTTTGAAGCAGGAAACGAGGAAAATTCCCCGCTTTTCATTCAAGCGAGTGAAGGAGCGATCA
AATACATGGGGATTGATATGGCGGTGGGCATGGTGAAAACCATGTGCGAACGCTACCCGCACATTCCTGTAGCCTTACAC
CTAGATCATGGCACGACTTTTGAAAGCTGTGAAAAAGCCGTGAAAGCGGGTTTCACTTCTGTGATGATTGATGCGTCTCA
TCATGTTTTTGAAGAAAATTTGGAATTGACTTCTAAAGTGGTCAAAATGGCGCATAACGCTGGAGTGAGCGTGGAAGCGG
AGTTAGGGCGTTTAATGGGGATTGAAGACAATATTTCAGTGGATGAAAAAGACGCGGTGTTAGTGAATCCTAAAGAAGCG
GAGCAGTTTGTCAAAGAATCTCAAGTGGATTACTTAGCCCCAGCCATTGGGACAAGCCATGGAGCGTTTAAGTTTAAGGG
CGAGCCCAAATTGGATTTTGAACGCTTGCAAGAAGTCAAAAGGCTCACTAATATCCCTTTAGTTTTGCATGGAGCGAGCG
CGATACCAGATAATGTGAGGAAATCTTATTTGGACGCTGGAGGCGATTTGAAAGGCTCTAAGGGCGTGCCTTTTGAATTT
TTACAAGAATCCATTAAGGGGGGGATCAATAAGGTCAATACCGACACGGACTTAAGGATCGCTTTCATCGCAGAAGTGCG
CAAGGTGGCTAATGAAGATAAGAGCCAATTTGATTTGAGGAAGTTTTTTTCTCCGGCCCAATTAGCACTTAAAAATGTGG
TCAAAGAGCGCATGAAACTTTTGGGCAGCGCTAATAAAATTTAA

Upstream 100 bases:

>100_bases
TTACAAGAAAAGCTTTTCCAAGAACGCATGAATCAACGCATTGAGGAACTAAGAAAGCACGCTAAAATTGTTATCAACAA
GTAATTGATGAGGTGTTGTT

Downstream 100 bases:

>100_bases
CCAACAAGGAAAGAATGTAACATGGCAATTGGGATGAGTGAGCTCAAAAAGGGCTTGAAAATTGAATTGGGTGGTGTGCC
TTATAGGATCGTAGAATACC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLVKGNEILLKAHEEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKTMCERYPHIPVALH
LDHGTTFESCEKAVKAGFTSVMIDASHHVFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA
EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEF
LQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI

Sequences:

>Translated_307_residues
MLVKGNEILLKAHEEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKTMCERYPHIPVALH
LDHGTTFESCEKAVKAGFTSVMIDASHHVFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA
EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEF
LQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI
>Mature_307_residues
MLVKGNEILLKAHEEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKTMCERYPHIPVALH
LDHGTTFESCEKAVKAGFTSVMIDASHHVFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA
EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEF
LQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=306, Percent_Identity=37.9084967320261, Blast_Score=214, Evalue=5e-57,
Organism=Escherichia coli, GI87082041, Length=302, Percent_Identity=35.4304635761589, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1788072, Length=293, Percent_Identity=33.1058020477816, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789293, Length=293, Percent_Identity=24.5733788395904, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33786; Mature: 33786

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKGNEILLKAHEEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDM
CEECCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEHHHH
AVGMVKTMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHVFEENLELTSKV
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHH
VKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAEQFVKESQVDYLAPAIGTSH
HHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHCCCC
GAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEF
CCEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHH
LQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGSANKI
HCCCCCC
>Mature Secondary Structure
MLVKGNEILLKAHEEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDM
CEECCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEHHHH
AVGMVKTMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHVFEENLELTSKV
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHEEEECHHHHHHHHHHHHHHH
VKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAEQFVKESQVDYLAPAIGTSH
HHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHCCCC
GAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEF
CCEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHH
LQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGSANKI
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]