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The map label for this gene is moeA [H]

Identifier: 108562593

GI number: 108562593

Start: 173974

End: 175149

Strand: Reverse

Name: moeA [H]

Synonym: HPAG1_0168

Alternate gene names: 108562593

Gene position: 175149-173974 (Counterclockwise)

Preceding gene: 108562594

Following gene: 108562592

Centisome position: 10.97

GC content: 38.18

Gene sequence:

>1176_bases
ATGATTAGTTTTAAAGAAGCTCTAAAAATCCATTCTAGCATTCCCCTAAAACCCTTAGAAATAGAGGTTGTCTCTTTGTT
TGAAAGCATAGGGTGCGTTTTGGCAGAGGATATTGTTTGCATTCACGCTTTGCCTAAATTCAATCAAAGTGCAATGGATG
GCTATGGGTTTAAAATGCAAGATTTAGGCCAAAAAACTCAAGTCATCCAACACATCTTTGCCGGAGATGATGTGAGCGCT
TTGGAAGTTAGAGAAAATGAATGCGTTAAAATCATGACTGGAGCGATGGTGCCAAAGGGAATAGAAACGATTATCCCTAT
AGAATGCATGCTAGAAAGCCATGAAAATTTTGCCCTAGCTCCCAAAGATTTTAAAATAAACGCCAATATCCGTCAAAAGG
GCGAAAACGCTTCTTTAAACAGCGTGTTAGTCCCTAAAAATACCCGTTTGAATTACGGGCATATCGCGCTCATTGCCTCT
CAAGGGTTAAAAGAAATCAAAGCGTTTAGAAAATTAAAAATCGCTCTCTTTAGCAGCGGCGATGAATTAGTGCCTTTAGG
GCAAAACGCCCTAGAATGCCAGGTTTATGATGTGAATTCAGTGGGTGTTTTTAACATGCTTAAAAACTACAACACGCATT
TTCTAGGGGTTTTAAAAGATGATAAAGATTTACAGCTTAAAAAACTTGAATTGCAAGGCTATGATGTCATCCTTTCAAGC
GCGGGGGTGAGTGTGGGGGATAAAGACTTTTTTAAAGACGCCTTGAAAGAAAGAAACGCCCTTTTTTATTATGAAAAAGT
CAATCTCAAACCTGGAAAACCGGTAACTTTAGCTAAACTCAATCAAAGTATTATTATAGGTTTACCGGGCAATCCTTTAA
GTTGCTTAGTCGTTTTACGAGTTTTGATTCTACCCTTATTGGAGCGCTTATCCTTAAATAAAGATTTTAAATTAAAACCC
TTTAAGGCTCAAATCAATGCCCCCTTAAAGCTTAAAGGCGAACGCGCGCATTTAATTTTAGGCAACTATTCAAACCACCA
GTTCATTCCTTACAACAACAACCGCTATGAATCAGGAGCGATTCAAGCCCTTGCGCGAGTGGATTCTATCGCTTTAATTG
ATGAAGGAGTTAGATTGGTTCAGGGCGAAATTGAAATTTTAAGGTTTGAAAATTAA

Upstream 100 bases:

>100_bases
TGTGGGCATTATTTTAATCGCTTCGGCTATCATGGGGCGTTTTAAAGAAGAAATCAGCCTGGCCTTTAGCGTTATTAGTA
AAATCTTTTAAAGGATCAAT

Downstream 100 bases:

>100_bases
AATGGCTTTTAACAATGCTATAATGATAAGTTCAAAACCCCACTCATAAAGGTTCTGTTTGTGGATAACTACACCTATAG
CGAATTGTTAAAAAGCTTGC

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MISFKEALKIHSSIPLKPLEIEVVSLFESIGCVLAEDIVCIHALPKFNQSAMDGYGFKMQDLGQKTQVIQHIFAGDDVSA
LEVRENECVKIMTGAMVPKGIETIIPIECMLESHENFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKDLQLKKLELQGYDVILSS
AGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLVVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYESGAIQALARVDSIALIDEGVRLVQGEIEILRFEN

Sequences:

>Translated_391_residues
MISFKEALKIHSSIPLKPLEIEVVSLFESIGCVLAEDIVCIHALPKFNQSAMDGYGFKMQDLGQKTQVIQHIFAGDDVSA
LEVRENECVKIMTGAMVPKGIETIIPIECMLESHENFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKDLQLKKLELQGYDVILSS
AGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLVVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYESGAIQALARVDSIALIDEGVRLVQGEIEILRFEN
>Mature_391_residues
MISFKEALKIHSSIPLKPLEIEVVSLFESIGCVLAEDIVCIHALPKFNQSAMDGYGFKMQDLGQKTQVIQHIFAGDDVSA
LEVRENECVKIMTGAMVPKGIETIIPIECMLESHENFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKDLQLKKLELQGYDVILSS
AGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLVVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYESGAIQALARVDSIALIDEGVRLVQGEIEILRFEN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=350, Percent_Identity=26.5714285714286, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI10880983, Length=350, Percent_Identity=26.5714285714286, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1787049, Length=317, Percent_Identity=36.5930599369085, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=354, Percent_Identity=27.1186440677966, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=337, Percent_Identity=23.4421364985163, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136978, Length=275, Percent_Identity=30.5454545454545, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638841, Length=275, Percent_Identity=30.5454545454545, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43514; Mature: 43514

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFKEALKIHSSIPLKPLEIEVVSLFESIGCVLAEDIVCIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHH
DLGQKTQVIQHIFAGDDVSALEVRENECVKIMTGAMVPKGIETIIPIECMLESHENFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKDLQLKKLELQGYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCEEEEEEC
AGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLVVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYESGA
HHHHHHHHHHCCCCCCEECCCHHCCCCCEEECCCEEEEEEECCCCCEEECCCCCCCCHHH
IQALARVDSIALIDEGVRLVQGEIEILRFEN
HHHHHHHHHHEEHHHCHHEEECCEEEEEECC
>Mature Secondary Structure
MISFKEALKIHSSIPLKPLEIEVVSLFESIGCVLAEDIVCIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHH
DLGQKTQVIQHIFAGDDVSALEVRENECVKIMTGAMVPKGIETIIPIECMLESHENFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKDLQLKKLELQGYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCEEEEEEC
AGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLVVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNHQFIPYNNNRYESGA
HHHHHHHHHHCCCCCCEECCCHHCCCCCEEECCCEEEEEEECCCCCEEECCCCCCCCHHH
IQALARVDSIALIDEGVRLVQGEIEILRFEN
HHHHHHHHHHEEHHHCHHEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]