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The map label for this gene is lldP [H]

Identifier: 108562564

GI number: 108562564

Start: 147698

End: 149353

Strand: Direct

Name: lldP [H]

Synonym: HPAG1_0139

Alternate gene names: 108562564

Gene position: 147698-149353 (Clockwise)

Preceding gene: 108562563

Following gene: 108562567

Centisome position: 9.25

GC content: 42.51

Gene sequence:

>1656_bases
GTGTCAGAATTTCATCAAGTCTATGACCCTTTGGGTAATATTTGGCTGAGCGCTCTTGTAGCCTTATTGCCGATTTTGTT
ATTTTTCTTATCCTTAATGGTTTTCAAGCTCAAAGGTTATGCGGCGGCCTTTTTGAGCGTGGCTCTGTCAGTCATTATTG
CGGTTTTAGTGTATAAAATGCCTGTTAGCATGGTGGGTTCAAGCTTTCTTTATGGCTTTCTTTATGGCTTATGGCCGATC
GCATGGATTATTATTGCGGCGATTTTTTTATACAAACTCAGCGTTAAATCCGGCTATTTTGAAATTTTAAAAGAAAGCGT
CCAATCCATCACTTTAGATCACCGGATTTTAGTGATTTTGATTGGCTTTTGTTTTGGCTCGTTTTTAGAAGGAGCGATCG
GGTTTGGAGGGCCTATTGCCATTACAGCAGCGATTTTAGTGGGCTTAGGGTTAAGCCCCTTATATTCTGCCGGATTGTGC
CTAATCGCTAATACCGCTCCTGTGGCTTTTGGCGCAGTGGGTATCCCTATAAGCGCTATGGCGAGCGCGGTAGGGGTTCC
AGCGATTTTAATTTCAGCCATGACGGGTAAAATCCTCTTTTTTGTGAGCTTGTTAGTGCCGTTTTTCATTGTGTTTTTGA
TGGATGGCTTTAAGGGGATTAAAGAAACTTTTCCGGCCGTTTTTATCGCGGCTTTTTCTTTCGCTATCGCGCAATTTTTA
AGCTCTAATTATTTAGGGCCAGAATTGCCTGGTATTATTTCAGCCCTTGTTTCACTCGTTGCAACAGCGCTCTTTTTGAA
ATTTTGGCAGCCTAAAGCGATTTTTAGAAGCGACGGCAAAGCGGCCTCATTCACTAAGAGTAACCATCATATCTGTAAAA
TTTATGTCGCTTGGTCTCCTTTTGTGATTTTGGTTTTAGTGATTGTTTTATGGATACAGCCTTTTTTTAAGGCTTTATTT
GAAAAAGACGGCTTATTAGCTTTTTCTAATTTTTATTTTGAATTCAATAACATCAGCAACCACATCTTTAAAAGCCCGCC
TTTTGTAGAAGCCAATCAAAGCGTGAGTTTTCCGGTGGTGTTTAAATTTCTCTTAATCAACACGGTTGGTACTTCCATTT
TTTTGGCCGCTCTTGTTAGCATGCTCGTTTTAAGGGTGCGAGTGAGCGATGCGCTGAGCGTTTTTGGCGAAACCTTGAAA
GAAATGCGCTATCCCATTCTTACTATTGGTTTAGTCTTAAGCTTTGCCTATGTGTCTAATTACAGCGGGATTTCTTCCAC
TCTAGCCTTAGCGCTCACGCATACGGGTTTGGCTTTTACTTTTTTCTCGCCCTTGATCGGGTGGGTAGGCGTGTTTTTAA
CCGGAAGCGATACGAGCTCTAATCTTTTATTTGGCTCTTTACAGCAACTCACCGCCCAACGATTGCACCTCCCTGAGGTT
TTAACCCTAACGGCTAATACCGTGGGTGGTACTTTGGGCAAAATGATAAGCCCTCAAAGCATCGCTATCGCTTGCGCAGC
GGTGGGATTAGCCGGGAAAGAGAGCGATTTGTTCAAATTCACGGTTAAATACTCCCTTATTTTTGTAGCGATCATGGGAG
TTGTGATTAGCGCGATTGCGTATTTGATCCCTGAAGTGGTGCCTGCGATAAAGTAG

Upstream 100 bases:

>100_bases
ACTCTTATTGCTTATGTCTTCCCCTTTATTATCCCGGTTACTCCTACTTAATGGAGGGGGTTTAGGGGAGTAAGAGAATA
TTTTTTTAAAGGGATTTTTA

Downstream 100 bases:

>100_bases
AGCCATTTTAGATTTGGCAGGGTTTAACCCCCAAATAAATTTTTTTGTTTTAAAAAATGCAAGATTTTAAGCGTCATAGA
GCTTATGGGTAAGGTCTCTA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVALSVIIAVLVYKMPVSMVGSSFLYGFLYGLWPI
AWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYSAGLC
LIANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLLVPFFIVFLMDGFKGIKETFPAVFIAAFSFAIAQFL
SSNYLGPELPGIISALVSLVATALFLKFWQPKAIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALF
EKDGLLAFSNFYFEFNNISNHIFKSPPFVEANQSVSFPVVFKFLLINTVGTSIFLAALVSMLVLRVRVSDALSVFGETLK
EMRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEV
LTLTANTVGGTLGKMISPQSIAIACAAVGLAGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK

Sequences:

>Translated_551_residues
MSEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVALSVIIAVLVYKMPVSMVGSSFLYGFLYGLWPI
AWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYSAGLC
LIANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLLVPFFIVFLMDGFKGIKETFPAVFIAAFSFAIAQFL
SSNYLGPELPGIISALVSLVATALFLKFWQPKAIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALF
EKDGLLAFSNFYFEFNNISNHIFKSPPFVEANQSVSFPVVFKFLLINTVGTSIFLAALVSMLVLRVRVSDALSVFGETLK
EMRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEV
LTLTANTVGGTLGKMISPQSIAIACAAVGLAGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK
>Mature_550_residues
SEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVALSVIIAVLVYKMPVSMVGSSFLYGFLYGLWPIA
WIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYSAGLCL
IANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLLVPFFIVFLMDGFKGIKETFPAVFIAAFSFAIAQFLS
SNYLGPELPGIISALVSLVATALFLKFWQPKAIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALFE
KDGLLAFSNFYFEFNNISNHIFKSPPFVEANQSVSFPVVFKFLLINTVGTSIFLAALVSMLVLRVRVSDALSVFGETLKE
MRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEVL
TLTANTVGGTLGKMISPQSIAIACAAVGLAGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=553, Percent_Identity=54.9728752260398, Blast_Score=577, Evalue=1e-165,
Organism=Escherichia coli, GI1789347, Length=555, Percent_Identity=51.5315315315315, Blast_Score=546, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59437; Mature: 59306

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCC
>Mature Secondary Structure 
SEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVALSVIIAVLVYKM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVSMVGSSFLYGFLYGLWPIAWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYSAGLCLIANTAPVAFGAVGIPISAM
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCHHHCCCCCCHHHH
ASAVGVPAILISAMTGKILFFVSLLVPFFIVFLMDGFKGIKETFPAVFIAAFSFAIAQFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSNYLGPELPGIISALVSLVATALFLKFWQPKAIFRSDGKAASFTKSNHHICKIYVAWSP
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEECCCCCEEEEEECHHH
FVILVLVIVLWIQPFFKALFEKDGLLAFSNFYFEFNNISNHIFKSPPFVEANQSVSFPVV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHEEEECCCCHHHCCCCCCCCCCCCCCHHHH
FKFLLINTVGTSIFLAALVSMLVLRVRVSDALSVFGETLKEMRYPILTIGLVLSFAYVSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
YSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCHH
LTLTANTVGGTLGKMISPQSIAIACAAVGLAGKESDLFKFTVKYSLIFVAIMGVVISAIA
HEEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLIPEVVPAIK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]