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The map label for this gene is czcR [H]

Identifier: 107023057

GI number: 107023057

Start: 1671827

End: 1672504

Strand: Reverse

Name: czcR [H]

Synonym: Bcen_1505

Alternate gene names: 107023057

Gene position: 1672504-1671827 (Counterclockwise)

Preceding gene: 107023058

Following gene: 107023056

Centisome position: 50.77

GC content: 67.11

Gene sequence:

>678_bases
ATGCGCATCCTGATAGTCGAAGACGAACCGAAGACGGGCGCGTACCTGAAGAAGGGGCTCGAGGAATCGGGTTTCAGCGT
CGATCTCGCGAAGGACGGCGGCGAAGGGCTGACGCTCGCGCAGGAAGAGCGTTACGACGTGATCGTGCTCGACGTGATGC
TGCCCGTGCTCGACGGCTGGGCCGTGCTCAAGCGGCTGCGCGACACGCACACGACGCCGGTGCTGTTCCTGACCGCGCGC
GACGACGTGCAGGACCGCGTGCACGGCCTCGAACTCGGCGCCGACGACTACCTCGTGAAGCCGTTCGCGTTCGTCGAGCT
GCTCGCTCGCATCCGCACGCTCGCGCGTCGCGGGCCGCCGCGCGAGACCGAACATCTGGCGGTCGGCGATCTGGAAATCG
ACGTGGTGCGCCGCCGCGTGAAGCGCGGCGCCACGCGGATCGACCTGACGCCGCGCGAATTCTCGCTGCTGCAACTGCTC
GCGCGCCGGCAGGGCGAGGTGCTGAGCCGCACGCAGATCGCGTCGTACGTATGGGACATGAATTTCGACAGCGACACCAA
CGTCGTCGAGGTCGCGATCCGGCGCCTGCGCGCGAAGATCGACGACGCGTTTCCCGTCAAGCTGATCCATACCGTGCGCG
GCGTCGGCTACGTGCTCGAACCGAAGGACGACGCATGA

Upstream 100 bases:

>100_bases
GTTTTGTCATCTACGCCGTTCGCGCTTGCACGCAGCGAAGCCGTGTCGCCGTTTCCGGGTAACATCGCCGGATGTCCCCA
CGAATGCGACGGAGCCGGCC

Downstream 100 bases:

>100_bases
CGCGCCCGCGCTCGCTCGCCGCGACGCTCGCGCTCGCGTTCGCCGCGACCACGCTGGCCGCGTTCGCGCTCGTCGGCGCG
TATGTGTATGCGGGCCTCGA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRILIVEDEPKTGAYLKKGLEESGFSVDLAKDGGEGLTLAQEERYDVIVLDVMLPVLDGWAVLKRLRDTHTTPVLFLTAR
DDVQDRVHGLELGADDYLVKPFAFVELLARIRTLARRGPPRETEHLAVGDLEIDVVRRRVKRGATRIDLTPREFSLLQLL
ARRQGEVLSRTQIASYVWDMNFDSDTNVVEVAIRRLRAKIDDAFPVKLIHTVRGVGYVLEPKDDA

Sequences:

>Translated_225_residues
MRILIVEDEPKTGAYLKKGLEESGFSVDLAKDGGEGLTLAQEERYDVIVLDVMLPVLDGWAVLKRLRDTHTTPVLFLTAR
DDVQDRVHGLELGADDYLVKPFAFVELLARIRTLARRGPPRETEHLAVGDLEIDVVRRRVKRGATRIDLTPREFSLLQLL
ARRQGEVLSRTQIASYVWDMNFDSDTNVVEVAIRRLRAKIDDAFPVKLIHTVRGVGYVLEPKDDA
>Mature_225_residues
MRILIVEDEPKTGAYLKKGLEESGFSVDLAKDGGEGLTLAQEERYDVIVLDVMLPVLDGWAVLKRLRDTHTTPVLFLTAR
DDVQDRVHGLELGADDYLVKPFAFVELLARIRTLARRGPPRETEHLAVGDLEIDVVRRRVKRGATRIDLTPREFSLLQLL
ARRQGEVLSRTQIASYVWDMNFDSDTNVVEVAIRRLRAKIDDAFPVKLIHTVRGVGYVLEPKDDA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=59.1111111111111, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=52.9953917050691, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=42.2222222222222, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=38.6666666666667, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=38.1818181818182, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.4841628959276, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=37.219730941704, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.0090497737557, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=35.2173913043478, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=36.0730593607306, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=38.8646288209607, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=32.8888888888889, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=30.6666666666667, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=30.1724137931034, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=37.007874015748, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=35.4545454545455, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=136, Percent_Identity=30.8823529411765, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25456; Mature: 25456

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDEPKTGAYLKKGLEESGFSVDLAKDGGEGLTLAQEERYDVIVLDVMLPVLDGW
CEEEEEECCCCCCHHHHHCHHHCCCEEEEECCCCCCCEEECCCCCCEEEHHHHHHHHHHH
AVLKRLRDTHTTPVLFLTARDDVQDRVHGLELGADDYLVKPFAFVELLARIRTLARRGPP
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCC
RETEHLAVGDLEIDVVRRRVKRGATRIDLTPREFSLLQLLARRQGEVLSRTQIASYVWDM
CCCCEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEC
NFDSDTNVVEVAIRRLRAKIDDAFPVKLIHTVRGVGYVLEPKDDA
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure
MRILIVEDEPKTGAYLKKGLEESGFSVDLAKDGGEGLTLAQEERYDVIVLDVMLPVLDGW
CEEEEEECCCCCCHHHHHCHHHCCCEEEEECCCCCCCEEECCCCCCEEEHHHHHHHHHHH
AVLKRLRDTHTTPVLFLTARDDVQDRVHGLELGADDYLVKPFAFVELLARIRTLARRGPP
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCC
RETEHLAVGDLEIDVVRRRVKRGATRIDLTPREFSLLQLLARRQGEVLSRTQIASYVWDM
CCCCEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEC
NFDSDTNVVEVAIRRLRAKIDDAFPVKLIHTVRGVGYVLEPKDDA
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]