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The map label for this gene is czcS [H]

Identifier: 107023056

GI number: 107023056

Start: 1670370

End: 1671830

Strand: Reverse

Name: czcS [H]

Synonym: Bcen_1504

Alternate gene names: 107023056

Gene position: 1671830-1670370 (Counterclockwise)

Preceding gene: 107023057

Following gene: 107023052

Centisome position: 50.75

GC content: 71.59

Gene sequence:

>1461_bases
ATGACGCGCCCGCGCTCGCTCGCCGCGACGCTCGCGCTCGCGTTCGCCGCGACCACGCTGGCCGCGTTCGCGCTCGTCGG
CGCGTATGTGTATGCGGGCCTCGAGCGGCAGGTGAACACGCAGGACGATCTCGACATCGTGCTGGCCGCGCGCCACACGC
GCCGGCTCGCGGGCGAGCTCGAGTCGCTCGACGCGGCGCGTGCGCACGCCGAGCGACTGACGAGCCAGGTGCTGGGCAAC
GAGGCGCTGTCGATGGCCGTCGTCGATGCGGGAGGCGACGTGCTCGCGCGCCACAACGTCCGGCTCGCCGCGCTCGACGA
GGCGCCGGCGGCCGCGTCGACTCCGTTGGCCGACGCGCAACTGTTCGCGCCGCACGCGGTGCCGGTTCCCGCAAACGACC
GGATCACGGCCGACCGGCTCGTCACGTGGACCGCCGACGGCGGCACGCCGATGCGCGGCGTCGTGATCGAGGCCGCGCTC
GGCGACCGCACGCCGATCCGCATCGCGATCGCGCGCAACATGCGCGACCGCGCCGATCTGCTCGACGGCTACCGCGACCG
GCTCAAGCTCGCCGGCGGGCTCGGCGCGCTGTTCGCGCTGCTGCTCGGCTACTGGCTGATCCGCAAGGCGCTTGCGCCGC
TGCGCGAGATCGTCGACGACACCGGCCGGATCACGGTCGACAAGCTCGACACGCGGCTCGACGCGTCGCGTGCGCCGCCC
GAGCTGCGCGCGCTCGTCGATGCGCAGAACGCGATGCTCGGCCGCCTGCAGCAGGCGTTCGCGCATCTGTCGCAATTCAG
CGCCGATCTCGCGCACGACCTGCGCACGCCGCTGAACAACATGCGCGGCGCCACCGAAGTCGCGCTCGCGCGGCCGCGTT
CGGTCGACGAGTACCAGACGCTGCTCGAATCGAATCTCGAGGAATACGACCGTCTCGCGCGGATGATCGAGAACGTGCTG
TTTCTCGCGCGCGCCGAGCATCCGAGTTTCGTCACGCGGCGGCGCGCGTTCGACGTGCGCGAAGAACTCGAGCGCATCGC
GGAGTATTTCGAAGGGCTCGCCGACGAAGCGGGCTCGACGTTGCGCGTCGACGGGCACGGGCAGCTGACCGCCGACGTCG
AGCTGTTTCGTCGCGCCGTCGGCAACCTGCTCGCGAACGCGCTGCGTTACACGCCGGCCGGCGGCGTCATCACGCTCGCC
GTCGACGAAACGCCGGATGCGGTACGCGTCGTCGTCGAGAATCCGGGCGAGCCGATCGATCCTGCATTGCTGCCGCGGAT
CTTCGACCGCTTCGTGCGCGGCGATCCCGCGCGCAGCGGCGGTGTACCGGGCGGCACGGCCGGGCTCGGCCTCGCGATCG
TGCGCTCGGTGATGGAACTGCACGGCGGCACCGCGCAGGTCGAAAGCGACGCGCGCGGCACGCGTTTCGTGCTCACGTTC
AACCGGCCGCCTGTTGCTTGA

Upstream 100 bases:

>100_bases
CGATCCGGCGCCTGCGCGCGAAGATCGACGACGCGTTTCCCGTCAAGCTGATCCATACCGTGCGCGGCGTCGGCTACGTG
CTCGAACCGAAGGACGACGC

Downstream 100 bases:

>100_bases
CGGCGGCGGGTTGGGGCCGCGCGGTTGCCGCGGCGTCCTTCTTGCCGGTGTTCGATTCCGCGTCTGCCCCGGCGCTCGCG
CTCGCCTGCCAGCCGCCGCC

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTRPRSLAATLALAFAATTLAAFALVGAYVYAGLERQVNTQDDLDIVLAARHTRRLAGELESLDAARAHAERLTSQVLGN
EALSMAVVDAGGDVLARHNVRLAALDEAPAAASTPLADAQLFAPHAVPVPANDRITADRLVTWTADGGTPMRGVVIEAAL
GDRTPIRIAIARNMRDRADLLDGYRDRLKLAGGLGALFALLLGYWLIRKALAPLREIVDDTGRITVDKLDTRLDASRAPP
ELRALVDAQNAMLGRLQQAFAHLSQFSADLAHDLRTPLNNMRGATEVALARPRSVDEYQTLLESNLEEYDRLARMIENVL
FLARAEHPSFVTRRRAFDVREELERIAEYFEGLADEAGSTLRVDGHGQLTADVELFRRAVGNLLANALRYTPAGGVITLA
VDETPDAVRVVVENPGEPIDPALLPRIFDRFVRGDPARSGGVPGGTAGLGLAIVRSVMELHGGTAQVESDARGTRFVLTF
NRPPVA

Sequences:

>Translated_486_residues
MTRPRSLAATLALAFAATTLAAFALVGAYVYAGLERQVNTQDDLDIVLAARHTRRLAGELESLDAARAHAERLTSQVLGN
EALSMAVVDAGGDVLARHNVRLAALDEAPAAASTPLADAQLFAPHAVPVPANDRITADRLVTWTADGGTPMRGVVIEAAL
GDRTPIRIAIARNMRDRADLLDGYRDRLKLAGGLGALFALLLGYWLIRKALAPLREIVDDTGRITVDKLDTRLDASRAPP
ELRALVDAQNAMLGRLQQAFAHLSQFSADLAHDLRTPLNNMRGATEVALARPRSVDEYQTLLESNLEEYDRLARMIENVL
FLARAEHPSFVTRRRAFDVREELERIAEYFEGLADEAGSTLRVDGHGQLTADVELFRRAVGNLLANALRYTPAGGVITLA
VDETPDAVRVVVENPGEPIDPALLPRIFDRFVRGDPARSGGVPGGTAGLGLAIVRSVMELHGGTAQVESDARGTRFVLTF
NRPPVA
>Mature_485_residues
TRPRSLAATLALAFAATTLAAFALVGAYVYAGLERQVNTQDDLDIVLAARHTRRLAGELESLDAARAHAERLTSQVLGNE
ALSMAVVDAGGDVLARHNVRLAALDEAPAAASTPLADAQLFAPHAVPVPANDRITADRLVTWTADGGTPMRGVVIEAALG
DRTPIRIAIARNMRDRADLLDGYRDRLKLAGGLGALFALLLGYWLIRKALAPLREIVDDTGRITVDKLDTRLDASRAPPE
LRALVDAQNAMLGRLQQAFAHLSQFSADLAHDLRTPLNNMRGATEVALARPRSVDEYQTLLESNLEEYDRLARMIENVLF
LARAEHPSFVTRRRAFDVREELERIAEYFEGLADEAGSTLRVDGHGQLTADVELFRRAVGNLLANALRYTPAGGVITLAV
DETPDAVRVVVENPGEPIDPALLPRIFDRFVRGDPARSGGVPGGTAGLGLAIVRSVMELHGGTAQVESDARGTRFVLTFN
RPPVA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=323, Percent_Identity=39.6284829721362, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788279, Length=315, Percent_Identity=31.7460317460317, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786600, Length=213, Percent_Identity=30.0469483568075, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=29.5302013422819, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788393, Length=263, Percent_Identity=26.2357414448669, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=29.6428571428571, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789403, Length=250, Percent_Identity=30.4, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789149, Length=337, Percent_Identity=24.3323442136499, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=246, Percent_Identity=30.8943089430894, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=28.2157676348548, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=29.7872340425532, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=26.2008733624454, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=22.5806451612903, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52446; Mature: 52315

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRSLAATLALAFAATTLAAFALVGAYVYAGLERQVNTQDDLDIVLAARHTRRLAGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ESLDAARAHAERLTSQVLGNEALSMAVVDAGGDVLARHNVRLAALDEAPAAASTPLADAQ
HHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCEEEECCEEEEEECCCCCCCCCCCCCHH
LFAPHAVPVPANDRITADRLVTWTADGGTPMRGVVIEAALGDRTPIRIAIARNMRDRADL
HCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHH
LDGYRDRLKLAGGLGALFALLLGYWLIRKALAPLREIVDDTGRITVDKLDTRLDASRAPP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCH
ELRALVDAQNAMLGRLQQAFAHLSQFSADLAHDLRTPLNNMRGATEVALARPRSVDEYQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHH
LLESNLEEYDRLARMIENVLFLARAEHPSFVTRRRAFDVREELERIAEYFEGLADEAGST
HHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LRVDGHGQLTADVELFRRAVGNLLANALRYTPAGGVITLAVDETPDAVRVVVENPGEPID
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCC
PALLPRIFDRFVRGDPARSGGVPGGTAGLGLAIVRSVMELHGGTAQVESDARGTRFVLTF
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEE
NRPPVA
CCCCCC
>Mature Secondary Structure 
TRPRSLAATLALAFAATTLAAFALVGAYVYAGLERQVNTQDDLDIVLAARHTRRLAGEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ESLDAARAHAERLTSQVLGNEALSMAVVDAGGDVLARHNVRLAALDEAPAAASTPLADAQ
HHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCEEEECCEEEEEECCCCCCCCCCCCCHH
LFAPHAVPVPANDRITADRLVTWTADGGTPMRGVVIEAALGDRTPIRIAIARNMRDRADL
HCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHH
LDGYRDRLKLAGGLGALFALLLGYWLIRKALAPLREIVDDTGRITVDKLDTRLDASRAPP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCH
ELRALVDAQNAMLGRLQQAFAHLSQFSADLAHDLRTPLNNMRGATEVALARPRSVDEYQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHH
LLESNLEEYDRLARMIENVLFLARAEHPSFVTRRRAFDVREELERIAEYFEGLADEAGST
HHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LRVDGHGQLTADVELFRRAVGNLLANALRYTPAGGVITLAVDETPDAVRVVVENPGEPID
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCC
PALLPRIFDRFVRGDPARSGGVPGGTAGLGLAIVRSVMELHGGTAQVESDARGTRFVLTF
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEE
NRPPVA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]