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The map label for this gene is mro [H]

Identifier: 107023009

GI number: 107023009

Start: 1613410

End: 1614573

Strand: Reverse

Name: mro [H]

Synonym: Bcen_1457

Alternate gene names: 107023009

Gene position: 1614573-1613410 (Counterclockwise)

Preceding gene: 107023010

Following gene: 107023006

Centisome position: 49.01

GC content: 67.96

Gene sequence:

>1164_bases
ATGAAACGACGCTGGCCGCGACAACCGATGCTCGTGATGGGTGTGTTCGCAACGTTCGGGCTGCACGCAGCCGTTGCATC
GGCGGCGCCCGAAGTCTCGATCAGCCGAGCCGATTACGGGACGACCGCGACCGGGCAGGCGGTGAGCCAGTACACGCTCG
CGAACCGGCGCGGCGTGACGCTGAAAGTCATCACGTACGGCGGTATCGTGACCGCGCTCGACGTGCCCGACCGCACCGGG
CACGCGGCCGACATCGTGCTCGGCTTCGATTCGCTGCGCGACTACGAGGCGCACAACGGCAACATCCATTTCGGCGCGCT
GATCGGCCGGTATGCGAACCGCATCGCGGGCGGGCGCTTCGCGCTCGACGGCAAGACGTGGAAGCTGCCGGTCAACGACG
GGCCGAACACGCTGCACGGCGGCCCCGACAGTTTCGACGCGAAGGTCTGGACGGTCACCGGCACGCACAGCGACGCGACC
GGTTCGAGCGTCACGCTGCGCTACGTGAGCCCCGACGGCGAGAACGGCTTCCCCGGCACGTTGACGACGGACGTGACCTA
TACGCTGACCGGCGACAACCAGATCCGCATCGACTACCGCGCCACGACGGACAAGAACACGGTCGTCAACCTGACCAACC
ACAGCTACTTCAATCTGGCCGGGCAGGCGGGCGGCAGCGTCGAGCGGCAACTGATCGAGATCGCCGCATCGCGCTTCACG
CCGACCGACGATACGTCGATTCCGACCGGGCAACTGGCGAGCGTCGCGGGCACGCCGATGGACCTGCGCCAGCCGACGCC
GATCGGCGCGCATTTGCGCGATGCGTATCCGCAGCTCGCGATCGCGCATGGCTACGACCAGAACTGGGTGCTCGACCAGG
GCGGCCAGCCGGCGCCGGCGTTCGCCGCGCGTGCCTACGACCCGGCGTCGGGGCGTTTCCTCGAGCTGTACACGACGCAG
CCGGGGCTGCAGTTCTATACGGCCAACGGGTTGAACGGCAGCGTCGCGGGCAAGGGCGGCACGGTCTACCGGCAAACCGA
TGCATTCGCGCTGGAAGCCGAGCATTTCCCCGATTCGCCGAATCATCCGGCCTTCCCGTCGACGGCGCTCAAGCCGGGCG
AGACGCTGCACGAAGTGACGGTGTGGCGGGTGGGCGCGCGATGA

Upstream 100 bases:

>100_bases
CGTCGCGACGCGGATGCGGGGCGCGGCATGACAACCGCGGCGACGTGCAGGCATGCAACTTGCGCGGCCGCACGGGCCGC
ACTACTTTGGAGAGATTTCC

Downstream 100 bases:

>100_bases
GCGGCGGCGTCGGCGGGCGCGCGGCGATCACACGTTGATCACGCCGCGCCCGAGTTCGATCACGCGCCCGCCGACGCCGA
TTTTGCCCGCGGCATCGACC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKRRWPRQPMLVMGVFATFGLHAAVASAAPEVSISRADYGTTATGQAVSQYTLANRRGVTLKVITYGGIVTALDVPDRTG
HAADIVLGFDSLRDYEAHNGNIHFGALIGRYANRIAGGRFALDGKTWKLPVNDGPNTLHGGPDSFDAKVWTVTGTHSDAT
GSSVTLRYVSPDGENGFPGTLTTDVTYTLTGDNQIRIDYRATTDKNTVVNLTNHSYFNLAGQAGGSVERQLIEIAASRFT
PTDDTSIPTGQLASVAGTPMDLRQPTPIGAHLRDAYPQLAIAHGYDQNWVLDQGGQPAPAFAARAYDPASGRFLELYTTQ
PGLQFYTANGLNGSVAGKGGTVYRQTDAFALEAEHFPDSPNHPAFPSTALKPGETLHEVTVWRVGAR

Sequences:

>Translated_387_residues
MKRRWPRQPMLVMGVFATFGLHAAVASAAPEVSISRADYGTTATGQAVSQYTLANRRGVTLKVITYGGIVTALDVPDRTG
HAADIVLGFDSLRDYEAHNGNIHFGALIGRYANRIAGGRFALDGKTWKLPVNDGPNTLHGGPDSFDAKVWTVTGTHSDAT
GSSVTLRYVSPDGENGFPGTLTTDVTYTLTGDNQIRIDYRATTDKNTVVNLTNHSYFNLAGQAGGSVERQLIEIAASRFT
PTDDTSIPTGQLASVAGTPMDLRQPTPIGAHLRDAYPQLAIAHGYDQNWVLDQGGQPAPAFAARAYDPASGRFLELYTTQ
PGLQFYTANGLNGSVAGKGGTVYRQTDAFALEAEHFPDSPNHPAFPSTALKPGETLHEVTVWRVGAR
>Mature_387_residues
MKRRWPRQPMLVMGVFATFGLHAAVASAAPEVSISRADYGTTATGQAVSQYTLANRRGVTLKVITYGGIVTALDVPDRTG
HAADIVLGFDSLRDYEAHNGNIHFGALIGRYANRIAGGRFALDGKTWKLPVNDGPNTLHGGPDSFDAKVWTVTGTHSDAT
GSSVTLRYVSPDGENGFPGTLTTDVTYTLTGDNQIRIDYRATTDKNTVVNLTNHSYFNLAGQAGGSVERQLIEIAASRFT
PTDDTSIPTGQLASVAGTPMDLRQPTPIGAHLRDAYPQLAIAHGYDQNWVLDQGGQPAPAFAARAYDPASGRFLELYTTQ
PGLQFYTANGLNGSVAGKGGTVYRQTDAFALEAEHFPDSPNHPAFPSTALKPGETLHEVTVWRVGAR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=350, Percent_Identity=44, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1786971, Length=345, Percent_Identity=37.1014492753623, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17557428, Length=331, Percent_Identity=32.3262839879154, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI115533334, Length=331, Percent_Identity=32.3262839879154, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319493, Length=323, Percent_Identity=28.7925696594427, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324399, Length=317, Percent_Identity=29.0220820189274, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322004, Length=312, Percent_Identity=28.8461538461538, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24659048, Length=354, Percent_Identity=41.2429378531073, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24668278, Length=348, Percent_Identity=39.367816091954, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24583720, Length=347, Percent_Identity=40.0576368876081, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24668282, Length=350, Percent_Identity=38.8571428571429, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24641876, Length=357, Percent_Identity=31.6526610644258, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41376; Mature: 41376

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRWPRQPMLVMGVFATFGLHAAVASAAPEVSISRADYGTTATGQAVSQYTLANRRGVT
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCE
LKVITYGGIVTALDVPDRTGHAADIVLGFDSLRDYEAHNGNIHFGALIGRYANRIAGGRF
EEEEEECCEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHCCCEE
ALDGKTWKLPVNDGPNTLHGGPDSFDAKVWTVTGTHSDATGSSVTLRYVSPDGENGFPGT
EECCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCE
LTTDVTYTLTGDNQIRIDYRATTDKNTVVNLTNHSYFNLAGQAGGSVERQLIEIAASRFT
EECCEEEEEECCCEEEEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCC
PTDDTSIPTGQLASVAGTPMDLRQPTPIGAHLRDAYPQLAIAHGYDQNWVLDQGGQPAPA
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCEEECCCCCCCCH
FAARAYDPASGRFLELYTTQPGLQFYTANGLNGSVAGKGGTVYRQTDAFALEAEHFPDSP
HHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCEECCCCCEEEEECCCEEEECCCCCCCC
NHPAFPSTALKPGETLHEVTVWRVGAR
CCCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MKRRWPRQPMLVMGVFATFGLHAAVASAAPEVSISRADYGTTATGQAVSQYTLANRRGVT
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCE
LKVITYGGIVTALDVPDRTGHAADIVLGFDSLRDYEAHNGNIHFGALIGRYANRIAGGRF
EEEEEECCEEEEEECCCCCCCEEEEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHCCCEE
ALDGKTWKLPVNDGPNTLHGGPDSFDAKVWTVTGTHSDATGSSVTLRYVSPDGENGFPGT
EECCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCE
LTTDVTYTLTGDNQIRIDYRATTDKNTVVNLTNHSYFNLAGQAGGSVERQLIEIAASRFT
EECCEEEEEECCCEEEEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCC
PTDDTSIPTGQLASVAGTPMDLRQPTPIGAHLRDAYPQLAIAHGYDQNWVLDQGGQPAPA
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCEEECCCCCCCCH
FAARAYDPASGRFLELYTTQPGLQFYTANGLNGSVAGKGGTVYRQTDAFALEAEHFPDSP
HHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCEECCCCCEEEEECCCEEEECCCCCCCC
NHPAFPSTALKPGETLHEVTVWRVGAR
CCCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]